Product image of Imazol Plus (Clotrimazole, Hexamidine Diisetionate) supplied by GNH India

Imazol Plus

Active Ingredient:
Clotrimazole, Hexamidine Diisetionate
Origin:
EU

Imazol Plus (Clotrimazole, Hexamidine Diisetionate)

Clotrimazole, the active ingredient in Imazol Plus, is an antifungal presented as a topical preparation for skin use. It treats superficial fungal infections such as tinea corporis, tinea pedis and cutaneous candidiasis in both adults and children, often in combination with the antiseptic Hexamidine diisetionate to broaden antimicrobial coverage.

GNH India supplies Imazol Plus as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Laboratoires Bailleul S.A.

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Indications & Clinical Uses

Imazol Plus is a topical antifungal/antiseptic used for common superficial skin infections.

  • Tinea corporis: reduces fungal growth and clears the ring‑shaped rash on the body.
  • Tinea pedis: alleviates itching and eliminates the dermatophyte causing athlete's foot.
  • Cutaneous candidiasis: eradicates Candida species from moist skin areas, promoting healing.

How It Works

  • Clotrimazole inhibits the synthesis of ergosterol, an essential component of fungal cell membranes, leading to increased membrane permeability and cell death. Hexamidine diisetionate disrupts microbial cell membranes and interferes with protein function, providing broad antiseptic activity against bacteria and yeasts. Together they act locally on the skin to eliminate pathogenic organisms.

Side Effects

Topical application of Imazol Plus may cause local reactions.

Common Side Effects

  • Mild burning or stinging at the application site.
  • Redness or erythema.
  • Pruritus or itching.
  • Dryness or flaking of the skin.
  • Minor irritation or rash.

Serious or Rare Side Effects

  • Severe allergic dermatitis with swelling.
  • Contact urticaria or hives.
  • Bullous skin reactions.
  • Secondary bacterial infection of the treated area.
  • Persistent or worsening irritation requiring medical review.

Precautions & Warnings

Before using Imazol Plus, consider the following precautions.

  • Allergic History: avoid if known hypersensitivity to clotrimazole, hexamidine or formulation excipients.
  • Open Wounds: do not apply on extensive open wounds or mucous membranes.
  • Pediatric Use: consult a healthcare professional before use on infants or young children.
  • Concomitant Skin Products: avoid using other topical medications on the same area unless directed.
  • Pregnancy and Breastfeeding: discuss with a clinician as safety data are limited.
  • Store at room temperature: keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

Imazol Plus may interact with other topical agents or systemic drugs.

Major Interactions (Avoid)

  • Concurrent use with other potent topical antifungals (e.g., terbinafine) may increase irritation risk.
  • Application over areas treated with corticosteroids can mask infection signs.

Moderate Interactions (Monitor Closely)

  • Use with occlusive dressings may enhance systemic absorption.
  • Systemic antifungal therapy (e.g., oral azoles) may potentiate local effects.
  • Antiseptic soaps containing chlorhexidine may reduce efficacy of the product.

Frequently Asked Questions

Imazol Plus is a topical preparation indicated for superficial fungal skin infections such as tinea corporis (ringworm), tinea pedis (athlete’s foot) and cutaneous candidiasis. It combines an antifungal and an antiseptic to treat and prevent secondary bacterial involvement.

Clotrimazole blocks the enzyme responsible for synthesising ergosterol, a key component of fungal cell membranes. Without ergosterol, the membrane becomes permeable, leading to fungal cell death. Hexamidine diisetionate adds antiseptic activity by disrupting microbial membranes.

The dosage regimen for Imazol Plus is determined by the prescribing clinician based on the infection type, severity and patient age. Typically, a thin layer is applied to the affected skin once or twice daily for the period advised by the healthcare professional.

Safety data for Imazol Plus in pregnancy and lactation are limited. Women who are pregnant, planning pregnancy or breastfeeding should discuss potential risks with their healthcare provider before using the product.

To order Imazol Plus, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Imazol Plus combines clotrimazole with hexamidine, offering both antifungal and antiseptic actions. Compared with single‑agent products such as terbinafine or miconazole, it may provide broader coverage against bacterial colonisation, though clinical choice depends on infection type, patient tolerance and physician preference.

Store Imazol Plus at room temperature, below 25 °C. Keep the container tightly closed, protect it from moisture and direct sunlight, and retain it in the original packaging until use.

Imazol Plus is applied topically to clean, dry skin. A thin film should be spread over the affected area and surrounding margin, usually once or twice daily as directed by a healthcare professional. Hands should be washed after application.

Serious risks, though rare, include severe allergic reactions such as contact dermatitis, urticaria, or bullous skin eruptions. If signs of a serious skin reaction or systemic symptoms develop, discontinue use and seek medical attention promptly.

Individuals with a known hypersensitivity to clotrimazole, hexamidine diisetionate or any excipients in the formulation should avoid Imazol Plus. It is also not recommended for use on extensive open wounds, mucous membranes or in patients where a clinician advises against topical antifungal therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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