Imazol Plus (Clotrimazole, Hexamidine Diisetionate)

Clotrimazole inhibits fungal ergosterol synthesis by blocking the enzyme lanosterol 14α‑demethylase, which is essential for fungal cell membrane formation. This disruption compromises membrane integrity, leading to fungal cell death. Hexamidine diisetionate adds broad‑spectrum antiseptic activity by disrupting microbial cell membranes.

The dosing regimen for Imazol Plus is determined by the prescribing healthcare professional based on the type and severity of the infection, the patient’s age, and the area of skin involved. Typically, a thin layer is applied to the affected area once or twice daily for the period recommended by the prescriber.

Safety data for clotrimazole and hexamidine diisetionate during pregnancy and lactation are limited. The product should be used only if the potential benefit justifies any potential risk to the fetus or infant, and the decision should be made by a qualified healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and the necessary import documentation.

Compared with single‑agent azole creams, Imazol Plus combines an azole (clotrimazole) with an antiseptic (hexamidine diisetionate), offering both antifungal and antibacterial activity. This dual mechanism can be advantageous in mixed infections, whereas monotherapy may be insufficient when bacterial colonisation co‑exists.

Imazol Plus should be stored at ambient temperature, below 25 °C, in its original container. Keep the product away from moisture, direct sunlight, and heat sources. Ensure the container is tightly closed when not in use to maintain product stability.

Imazol Plus is a topical preparation applied directly to clean, dry skin. A thin layer is spread over the affected area, gently massaged until absorbed. The frequency and duration of treatment are set by the prescriber, and hands should be washed before and after application.

Although rare, serious adverse reactions may include severe skin irritation, allergic dermatitis, bullous eruptions, or systemic hypersensitivity such as anaphylaxis. Patients should discontinue use and seek immediate medical attention if they experience extensive redness, swelling, blistering, or signs of an allergic reaction.

Imazol Plus should be avoided in individuals with known hypersensitivity to clotrimazole, hexamidine diisetionate, or any excipients in the formulation. It is also not recommended for use on extensive damaged skin, mucous membranes, or in patients where the safety profile in pregnancy and lactation has not been established without medical supervision.