Product image of Imdur (Isosorbide 5 Mononitrate) supplied by GNH India

Imdur

Active Ingredient:
Isosorbide 5 Mononitrate
Origin:
EU

Imdur (Isosorbide 5 Mononitrate)

Isosorbide 5-Mononitrate, the active ingredient in Imdur, is a nitrate vasodilator presented as an oral tablet for oral use. It is employed to relieve angina pectoris and chronic stable angina by improving myocardial oxygen supply in adult patients.

GNH India supplies Imdur as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with consistent quality and regulatory compliance. Our distribution network ensures timely delivery across Europe, Asia and the Americas. We adhere to stringent GMP standards and provide full documentation for regulatory submissions.

Manufacturer / TM Owner

Topridge Pharma (Ireland) Limited

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Indications & Clinical Uses

Isosorbide 5-Mononitrate is a nitrate vasodilator used in the management of coronary artery disease.

  • Angina pectoris: reduces the frequency and severity of chest pain episodes.
  • Chronic stable angina: improves exercise tolerance and delays onset of angina.
  • Prophylaxis of angina attacks: provides sustained nitrate release to prevent episodic angina.

How It Works

  • Isosorbide 5-Mononitrate is metabolized to release nitric oxide, which activates guanylate cyclase in vascular smooth muscle. The resulting increase in cyclic GMP causes relaxation of both venous and arterial vessels, lowering preload and afterload, and thereby enhancing myocardial oxygen delivery while reducing cardiac workload.

Side Effects

Isosorbide 5-Mononitrate may cause a range of adverse reactions.

Common Side Effects

  • Headache: throbbing pain often occurring shortly after dosing.
  • Dizziness or light‑headedness: related to blood pressure reduction.
  • Flushing: warm sensation and reddening of the skin.
  • Hypotension: measurable drop in blood pressure, especially when standing.
  • Nausea: mild gastrointestinal upset.
  • Palpitations: awareness of heartbeat irregularities.

Serious or Rare Side Effects

  • Severe hypotension: marked blood pressure fall requiring medical attention.
  • Syncope: sudden loss of consciousness.
  • Myocardial infarction: rare but possible in susceptible patients.
  • Allergic reactions: rash, itching, or swelling.
  • Methemoglobinemia: rare blood disorder causing cyanosis.
  • Life‑threatening arrhythmias: extremely uncommon but serious.

Precautions & Warnings

Before initiating therapy, clinicians should consider several safety measures.

  • Cardiovascular assessment: evaluate baseline blood pressure and heart rate.
  • Blood pressure monitoring: check regularly, especially after dose changes.
  • Concomitant nitrate use: avoid combining with other nitrate preparations.
  • Phosphodiesterase‑5 inhibitors: do not co‑administer with sildenafil, tadalafil, or similar agents.
  • Patient counseling: advise on rising slowly from sitting or lying positions to reduce orthostatic symptoms.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Isosorbide 5-Mononitrate can interact with several drug classes.

Major Interactions (Avoid)

  • Phosphodiesterase‑5 inhibitors (e.g., sildenafil, tadalafil): risk of profound hypotension.
  • Other nitrates (e.g., nitroglycerin, isosorbide dinitrate): additive vasodilatory effect.
  • Guanylate cyclase stimulators: excessive vasodilation.

Moderate Interactions (Monitor Closely)

  • Antihypertensive agents (ACE inhibitors, ARBs, beta‑blockers): may enhance blood pressure lowering.
  • Diuretics: potential for volume depletion and hypotension.
  • Calcium channel blockers: monitor for additive cardiovascular effects.
  • Oral contraceptives: may alter nitrate metabolism, requiring observation.

Frequently Asked Questions

Imdur contains isosorbide 5‑mononitrate, a nitrate vasodilator prescribed to prevent and treat episodes of angina pectoris and chronic stable angina by improving blood flow to the heart muscle.

After oral absorption, isosorbide 5‑mononitrate is converted to nitric oxide, which relaxes vascular smooth muscle through cyclic GMP signaling. This dilation reduces cardiac preload and afterload, enhancing myocardial oxygen supply while lowering heart workload.

The specific dose and dosing schedule for Imdur are determined by the prescribing clinician based on the patient’s clinical condition, response, and tolerance. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data for isosorbide 5‑mononitrate in pregnancy and lactation are limited. Healthcare providers should weigh potential benefits against risks before prescribing to pregnant or nursing women, and it is generally used only if clearly needed.

To request Imdur, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Imdur belongs to the nitrate class, offering long‑acting nitrate therapy, whereas alternatives such as beta‑blockers, calcium‑channel blockers, or ranolazine act via different mechanisms. Nitrates provide rapid symptom relief and are often used when other agents are insufficient or contraindicated.

Imdur tablets should be stored at room temperature, below 25 °C, in the original packaging to protect them from moisture and light. Keep the container tightly closed and out of reach of children.

Imdur is taken orally, usually with a glass of water. It can be taken with or without food, but patients should follow the prescriber’s guidance on timing relative to meals to minimize gastrointestinal discomfort.

Serious risks include severe hypotension, syncope, myocardial infarction, life‑threatening arrhythmias, and rare allergic reactions such as anaphylaxis. Patients should seek immediate medical attention if they experience fainting, chest pain, or signs of an allergic response.

Imdur is contraindicated in patients with known hypersensitivity to isosorbide 5‑mononitrate or other nitrates, those who have taken phosphodiesterase‑5 inhibitors within the past 24‑48 hours, and individuals with severe hypotension or uncompensated heart failure.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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