Product image of Imdur (Isosorbide 5 Mononitrate) supplied by GNH India

Imdur

Active Ingredient:
Isosorbide 5 Mononitrate
Origin:
EU

Imdur (Isosorbide 5 Mononitrate)

Isosorbide 5-Mononitrate, the active ingredient in Imdur, is an organic nitrate presented as an oral tablet for oral use. It is employed for the prophylaxis of angina pectoris in adults, helping to reduce the frequency of chest pain episodes by lowering myocardial oxygen demand.

GNH India supplies Imdur as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Topridge Pharma (Ireland) Limited

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Indications & Clinical Uses

Imdur belongs to the organic nitrate class and is used to manage angina‑related conditions.

  • Stable angina pectoris: reduces the frequency of chest pain attacks during daily activities.
  • Exercise‑induced angina: helps prevent pain triggered by physical exertion.
  • Effort angina: provides prophylactic relief for pain that occurs with sustained effort.

How It Works

  • Isosorbide 5‑Mononitrate is metabolized to release nitric oxide, which activates guanylate cyclase in vascular smooth muscle. The resulting increase in cyclic GMP causes relaxation of both venous and arterial vessels, decreasing preload and afterload, and thereby lowering myocardial oxygen consumption and alleviating anginal symptoms.

Side Effects

Isosorbide 5‑Mononitrate may cause a range of adverse reactions.

Common Side Effects

  • Headache: mild to moderate, often transient.
  • Flushing: warm sensation with reddening of skin.
  • Dizziness: especially upon standing quickly.
  • Nausea: occasional gastrointestinal upset.
  • Hypotension: mild drop in blood pressure.
  • Palpitations: awareness of heartbeat.

Serious or Rare Side Effects

  • Severe hypotension: marked blood pressure fall requiring medical attention.
  • Syncope: fainting episodes.
  • Methemoglobinemia: rare discoloration of blood.
  • Allergic reactions: rash, itching, or swelling.
  • Chest pain worsening: paradoxical increase in angina.
  • Liver enzyme elevation: abnormal liver function tests.

Precautions & Warnings

Before initiating therapy, consider the following precautions.

  • Concomitant nitrate therapy: avoid simultaneous use to prevent severe hypotension.
  • Phosphodiesterase‑5 inhibitors: do not combine with drugs like sildenafil due to risk of profound blood pressure drop.
  • Cardiovascular instability: use cautiously in patients with recent myocardial infarction or unstable angina.
  • Renal impairment: dose adjustment may be required in severe renal dysfunction.
  • Pregnancy: safety not established; avoid unless clearly needed.
  • Store at ambient temperature: keep below 25 °C, retain in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Isosorbide 5‑Mononitrate can interact with several medication classes.

Major Interactions (Avoid)

  • Other organic nitrates: additive vasodilatory effect leading to severe hypotension.
  • Phosphodiesterase‑5 inhibitors: risk of dangerous blood pressure reduction.
  • Antihypertensive agents: may cause excessive blood pressure lowering.

Moderate Interactions (Monitor Closely)

  • Diuretics: may enhance hypotensive response.
  • Beta‑blockers: combined effect on heart rate and blood pressure.
  • Calcium channel blockers: additive vasodilatory action.
  • Alcohol: can increase dizziness and hypotension.
  • Certain antibiotics (e.g., macrolides): may affect metabolism and plasma levels.

Frequently Asked Questions

Imdur contains isosorbide 5‑mononitrate and is prescribed to prevent episodes of angina pectoris. It helps reduce the frequency and severity of chest pain by improving blood flow to the heart during physical activity or stress.

The active ingredient releases nitric oxide, which relaxes vascular smooth muscle. This vasodilation lowers both preload and afterload, decreasing the heart’s oxygen demand and preventing the onset of anginal pain.

The specific dose and dosing schedule are determined by the prescribing clinician based on the patient’s condition, response, and tolerability. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data for isosorbide 5‑mononitrate in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To request Imdur, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Imdur belongs to the organic nitrate class, offering long‑acting nitrate therapy. Compared with short‑acting nitrates like nitroglycerin, it provides more stable plasma levels and once‑daily dosing, which can improve adherence and reduce the need for multiple daily doses.

Imdur tablets should be stored at ambient temperature, below 25 °C, in their original container. Protect them from moisture, heat and direct sunlight to maintain stability and potency throughout the shelf life.

Imdur is taken orally, usually with a glass of water. It can be taken with or without food, but patients should follow the prescriber’s guidance on timing relative to meals to minimize potential gastrointestinal discomfort.

Serious risks include severe hypotension, syncope, and rare cases of methemoglobinemia. Patients should seek immediate medical attention if they experience fainting, marked dizziness, or any signs of allergic reaction such as swelling or rash.

Imdur should be avoided in patients who are concurrently using other nitrates, phosphodiesterase‑5 inhibitors, or who have known hypersensitivity to isosorbide 5‑mononitrate. It is also contraindicated in patients with severe hypotension or recent unstable angina without physician supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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