Product image of Imdur (Isosorbide Mononitrate) supplied by GNH India

Imdur

Active Ingredient:
Isosorbide Mononitrate
Origin:
EU

Imdur (Isosorbide Mononitrate)

Isosorbide Mononitrate, the active ingredient in Imdur, is an organic nitrate presented as an oral tablet for oral use. It is used to prevent and treat episodes of angina pectoris in adults who require long‑term anti‑anginal therapy.

GNH India supplies Imdur as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Topridge Pharma (Ireland) Limited

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Indications & Clinical Uses

Imdur belongs to the organic nitrate class and is employed in the management of coronary artery disease‑related chest pain.

  • Chronic stable angina: reduces the frequency and severity of angina attacks.
  • Exercise‑induced angina: improves tolerance to physical activity.
  • Angina prophylaxis: maintains symptom control during daily activities.

How It Works

  • Isosorbide mononitrate is absorbed and metabolized to nitric oxide, which activates guanylate cyclase in vascular smooth muscle. The resulting increase in cyclic GMP leads to relaxation of both venous and arterial vessels, decreasing preload and afterload, and thereby lowering myocardial oxygen demand.

Side Effects

Isosorbide mononitrate may cause a range of adverse reactions, most of which are dose‑related and reversible.

Common Side Effects

  • Headache: throbbing or pressure sensation.
  • Dizziness or light‑headedness, especially on standing.
  • Flushing: warmth and redness of the face or neck.
  • Nausea or mild gastrointestinal upset.
  • Palpitations: awareness of heartbeat.

Serious or Rare Side Effects

  • Severe hypotension: marked drop in blood pressure causing fainting.
  • Methemoglobinemia: reduced oxygen‑carrying capacity of blood.
  • Allergic reactions: rash, itching, swelling, or difficulty breathing.
  • Chest pain worsening: paradoxical increase in angina.
  • Syncope: sudden loss of consciousness.

Precautions & Warnings

Before initiating therapy with Imdur, consider the following safety measures.

  • Concomitant nitrate use: avoid combined use with other nitrates to prevent severe hypotension.
  • Phosphodiesterase‑5 inhibitors: do not co‑administer with sildenafil, tadalafil, or vardenafil.
  • Cardiovascular status: monitor patients with unstable heart disease closely.
  • Renal or hepatic impairment: dose adjustment may be required based on clinical judgment.
  • Pregnancy and lactation: use only if the potential benefit justifies the potential risk.
  • Store at ambient temperature: keep below 25 °C, retain in the original container, and protect from moisture.

Avoid Interactions

Isosorbide mononitrate can interact with several drug classes, influencing its efficacy or safety.

Major Interactions (Avoid)

  • Other organic nitrates or nitroglycerin: additive vasodilatory effect leading to profound hypotension.
  • Phosphodiesterase‑5 inhibitors: risk of severe blood pressure fall.

Moderate Interactions (Monitor Closely)

  • Antihypertensive agents (e.g., ACE inhibitors, beta‑blockers): may enhance blood pressure‑lowering effect.
  • Diuretics: can increase the risk of orthostatic hypotension.
  • Alcohol: may potentiate vasodilatory side effects.
  • Certain antacids: may affect absorption if taken simultaneously.

Frequently Asked Questions

Imdur contains isosorbide mononitrate, an oral anti‑anginal medication used to prevent and treat episodes of angina pectoris in patients with chronic coronary artery disease. It helps reduce the frequency of chest pain by lowering the heart’s oxygen demand.

After oral absorption, isosorbide mononitrate is converted to nitric oxide, which relaxes vascular smooth muscle through the cyclic GMP pathway. This vasodilation decreases both preload and afterload, easing the workload on the heart and relieving angina symptoms.

The specific dose of Imdur is determined by the prescribing clinician based on the individual’s medical condition, response, and tolerance. Patients should follow the prescriber’s instructions and not adjust the dose without medical advice.

Safety data for isosorbide mononitrate in pregnancy and lactation are limited. It should only be used if the potential benefit outweighs any possible risk to the fetus or infant, and this decision must be made by a qualified healthcare professional.

To request Imdur, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Imdur belongs to the organic nitrate class, offering long‑acting nitrate therapy. Compared with short‑acting nitrates like nitroglycerin, it provides more stable plasma levels and fewer dosing fluctuations, which can improve adherence and reduce the incidence of tolerance when used appropriately.

Imdur tablets should be stored at ambient temperature, below 25 °C, in the original packaging to protect them from moisture and light. Keep the container tightly closed and out of reach of children.

Imdur is taken orally, usually with a glass of water. It can be taken with or without food, but patients should follow the prescriber’s guidance on timing relative to meals to ensure consistent absorption.

The most serious risks include severe hypotension, especially when combined with other vasodilators, and rare cases of methemoglobinemia. Patients should be alert for symptoms such as fainting, dizziness, or unusual shortness of breath and seek medical attention promptly.

Imdur should be avoided in patients who are concurrently using other organic nitrates or phosphodiesterase‑5 inhibitors, and in those with known hypersensitivity to isosorbide mononitrate or any component of the formulation. Clinicians should also assess suitability in patients with severe hypotension or unstable cardiac conditions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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