Product image of Imdur (Isosorbide Mononitrate) supplied by GNH India

Imdur

Active Ingredient:
Isosorbide Mononitrate
Origin:
EU

Imdur (Isosorbide Mononitrate)

Isosorbide Mononitrate, the active ingredient in Imdur, is a nitrate vasodilator presented as an oral tablet for oral use. It is employed in the prophylaxis of angina pectoris and the management of chronic stable angina in adult patients, reducing myocardial oxygen demand and improving exercise tolerance.

GNH India supplies Imdur as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring quality, regulatory compliance and reliable global distribution.

Manufacturer / TM Owner

Topridge Pharma (Ireland) Limited

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Indications & Clinical Uses

Imdur, a nitrate vasodilator, is used in the treatment of coronary artery disease‑related conditions.

  • Angina pectoris: reduces the frequency and severity of anginal attacks.
  • Chronic stable angina: improves exercise tolerance and decreases symptom burden.
  • Ischemic heart disease: helps prevent episodes of myocardial ischemia in patients with established disease.

How It Works

  • Isosorbide mononitrate is absorbed and metabolized to nitric oxide, which activates guanylate cyclase in vascular smooth muscle. The resulting increase in cyclic GMP leads to relaxation of veins and arteries, decreasing preload and afterload, lowering myocardial oxygen consumption, and thereby alleviating anginal symptoms.

Side Effects

Adverse reactions may occur with any nitrate therapy.

Common Side Effects

  • Headache: often transient and dose‑related.
  • Flushing: warm sensation, usually mild.
  • Dizziness or light‑headedness: related to blood pressure lowering.
  • Nausea: occasional gastrointestinal upset.

Serious or Rare Side Effects

  • Severe hypotension: may cause syncope or shock.
  • Reflex tachycardia: rapid heart rate in response to vasodilation.
  • Methemoglobinemia: rare blood disorder presenting with cyanosis.
  • Allergic reactions: rash, pruritus, or anaphylaxis.
  • Myocardial infarction: extremely rare but reported.

Precautions & Warnings

Before prescribing Imdur, clinicians should consider several safety measures.

  • Cardiovascular assessment: evaluate blood pressure and heart rate prior to initiation.
  • Concomitant PDE‑5 inhibitors: avoid due to risk of profound hypotension.
  • Tolerance development: monitor efficacy over time and adjust therapy if needed.
  • Renal impairment: use caution and consider dose adjustment.
  • Store at room temperature: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Isosorbide mononitrate may interact with several drug classes.

Major Interactions (Avoid)

  • Phosphodiesterase‑5 inhibitors (e.g., sildenafil): can cause severe hypotension.
  • Other nitrates (e.g., nitroglycerin, isosorbide dinitrate): additive vasodilatory effect.
  • Alcohol: enhances hypotensive response.

Moderate Interactions (Monitor Closely)

  • Antihypertensives (ACE inhibitors, beta‑blockers): may increase blood‑pressure lowering.
  • Diuretics: can potentiate volume depletion and hypotension.
  • Antiplatelet agents (e.g., aspirin, clopidogrel): monitor for increased bleeding risk.

Frequently Asked Questions

Imdur contains isosorbide mononitrate and is prescribed to prevent angina pectoris attacks and to manage chronic stable angina. It helps reduce the frequency of chest pain episodes by lowering the heart’s oxygen demand.

Isosorbide mononitrate is converted in the body to nitric oxide, which relaxes vascular smooth muscle. This vasodilation decreases preload and afterload, reducing myocardial oxygen consumption and alleviating anginal symptoms.

The specific dose of Imdur is determined by the prescribing clinician based on the patient’s condition, response, and tolerability. Dosage adjustments are made according to individual therapeutic needs and safety considerations.

Safety data for isosorbide mononitrate in pregnancy and lactation are limited. The medication should only be used if the potential benefit justifies any potential risk to the fetus or infant, and this decision must be made by a qualified healthcare professional.

To request Imdur, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Imdur belongs to the nitrate class, offering long‑acting vasodilation. Compared with short‑acting nitrates, it provides more stable plasma levels and fewer dosing peaks, which can improve adherence. It differs from beta‑blockers or calcium‑channel blockers that act through distinct mechanisms such as heart‑rate reduction or calcium antagonism.

Imdur should be stored at room temperature, below 25 °C, in its original container. Protect the tablets from moisture and direct sunlight to maintain stability and potency throughout its shelf life.

Imdur is taken orally, usually with a glass of water. It can be taken with or without food, but patients should follow the prescribing clinician’s instructions regarding timing and any specific administration guidelines.

The most serious risks include severe hypotension, which can lead to syncope or shock, and rare cases of methemoglobinemia. Patients should be educated to seek immediate medical attention if they experience fainting, persistent dizziness, or signs of low oxygen in the blood.

Imdur is contraindicated in patients with known hypersensitivity to isosorbide mononitrate or other nitrates, those who have taken phosphodiesterase‑5 inhibitors within the past 24‑48 hours, and individuals with severe hypotension or uncompensated heart failure unless specifically directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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