Product image of Imidazyl (Naphazoline Nitrate) supplied by GNH India

Imidazyl

Active Ingredient:
Naphazoline Nitrate
Origin:
EU

Imidazyl (Naphazoline Nitrate)

Naphazoline Nitrate, the active ingredient in Imidazyl, is a alpha‑adrenergic agonist presented as an eye drop for ocular use. It reduces conjunctival redness and swelling in adults and children.
GNH India supplies Imidazyl as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Recordati Industria Chimica E Farmaceutica S.P.A.

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Indications & Clinical Uses

Imidazyl is an ocular decongestant that acts on the conjunctival vasculature to alleviate redness and swelling.

  • Ocular redness: provides rapid reduction of visible redness by constricting conjunctival blood vessels.
  • Conjunctival hyperemia: diminishes vessel dilation, improving eye appearance and comfort.
  • Eye irritation due to minor inflammation: helps relieve mild swelling and redness associated with irritants.

How It Works

  • Naphazoline Nitrate selectively stimulates alpha‑adrenergic receptors on conjunctival blood vessels, leading to vasoconstriction. This reduces blood flow to the ocular surface, decreasing capillary engorgement, redness, and associated swelling without systemic absorption.

Side Effects

Imidazyl may cause a range of ocular and systemic reactions.

Common Side Effects

  • Stinging or burning sensation upon instillation.
  • Transient blurred vision.
  • Mild eye itching or dryness.
  • Temporary headache.

Serious or Rare Side Effects

  • Increased intra‑ocular pressure, especially in glaucoma patients.
  • Severe allergic reaction (e.g., swelling, rash, difficulty breathing).
  • Corneal ulceration or persistent eye pain.

Precautions & Warnings

Use Imidazyl with care and observe the following precautions.

  • Avoid use in patients with narrow‑angle glaucoma: risk of elevated intra‑ocular pressure.
  • Do not use if known hypersensitivity to naphazoline or any excipient: may trigger allergic response.
  • Limit application to 3‑4 times daily: prolonged use can cause rebound redness.
  • Do not apply to infected, ulcerated, or severely inflamed eyes: may worsen condition.
  • Store at room temperature: keep in the original container, protect from light and moisture.

Avoid Interactions

Imidazyl can interact with other medications affecting vascular tone.

Major Interactions (Avoid)

  • Concurrent use with MAO inhibitors: may potentiate vasoconstrictive effects.
  • Use with other ocular decongestants: risk of additive vasoconstriction.
  • Combination with sympathomimetic eye drops: may cause excessive vasoconstriction.

Moderate Interactions (Monitor Closely)

  • Use with topical anesthetics: may increase corneal toxicity.
  • Concurrent systemic alpha‑adrenergic agonists: monitor blood pressure for additive effects.

Frequently Asked Questions

Imidazyl is an over‑the‑counter eye drop used to relieve ocular redness and mild swelling caused by conjunctival hyperemia or minor irritation. It works by constricting the small blood vessels on the surface of the eye, providing rapid cosmetic and symptomatic improvement.

Naphazoline Nitrate is a selective alpha‑adrenergic receptor agonist. When applied to the eye, it binds to alpha receptors on conjunctival vessels, causing vasoconstriction. This reduces blood flow to the ocular surface, decreasing capillary dilation, redness, and associated swelling.

The appropriate dosing regimen for Imidazyl is determined by the prescribing healthcare professional. Typically, one or two drops are instilled in the affected eye(s) up to three to four times per day, but the exact frequency and duration should follow the prescriber’s instructions.

Safety data for Naphazoline Nitrate in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision should be made by a qualified healthcare provider.

To order Imidazyl, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Both Imidazyl (naphazoline nitrate) and tetrahydrozoline are alpha‑adrenergic agonists that reduce eye redness through vasoconstriction. Naphazoline generally has a slightly faster onset, while tetrahydrozoline may have a longer duration of action. Choice of product depends on clinician preference, patient response, and formulation availability.

Imidazyl should be stored at room temperature, away from direct sunlight and moisture. Keep the bottle tightly closed when not in use and retain it in its original packaging to protect the formulation from contamination.

Imidazyl is administered topically as eye drops. The patient should wash hands, tilt the head back, pull down the lower eyelid, and place the prescribed number of drops into the conjunctival sac. Avoid touching the tip of the bottle to the eye or any surface.

Serious risks include a rise in intra‑ocular pressure, especially in patients with narrow‑angle glaucoma, and rare allergic reactions that may cause swelling, rash, or breathing difficulties. Persistent eye pain or vision changes should prompt immediate medical evaluation.

Imidazyl should not be used by individuals with known hypersensitivity to naphazoline nitrate or any excipients, and it is contraindicated in eyes with narrow‑angle glaucoma, severe ocular infection, or ulceration. Patients with these conditions should consult a healthcare professional for alternative therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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