Product image of Imidin N 1 (Xylometazoline Hydrochloride) supplied by GNH India

Imidin N 1

Active Ingredient:
Xylometazoline Hydrochloride
Origin:
EU

Imidin N 1 (Xylometazoline Hydrochloride)

Xylometazoline Hydrochloride, the active ingredient in Imidin N 1, is an alpha‑adrenergic agonist (imidazoline derivative) presented as a nasal spray for topical nasal use. It relieves nasal congestion associated with the common cold, sinusitis and allergic rhinitis in adults and children.

GNH India supplies Imidin N 1 as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Sia Ingen Pharma

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Indications & Clinical Uses

Xylometazoline Hydrochloride is a nasal decongestant that acts on the upper‑respiratory tract to reduce swelling.

  • Nasal congestion due to common cold: provides rapid relief of blockage by constricting nasal mucosal vessels.
  • Sinusitis‑associated congestion: diminishes edema to improve sinus drainage and breathing.
  • Allergic rhinitis: lessens nasal swelling caused by allergen‑triggered inflammation.

How It Works

  • Xylometazoline Hydrochloride selectively stimulates alpha‑adrenergic receptors on the smooth muscle of nasal mucosal blood vessels. This activation causes vasoconstriction, which reduces blood flow, limits plasma exudation, and consequently decreases mucosal edema and nasal airway resistance, leading to decongestion.

Side Effects

Adverse reactions may occur following intranasal administration of Xylometazoline Hydrochloride.

Common Side Effects

  • Burning or stinging sensation in the nose
  • Nasal dryness or irritation
  • Sneezing
  • Headache
  • Mild epistaxis (nosebleed)

Serious or Rare Side Effects

  • Severe hypertension or tachycardia
  • Rebound nasal congestion with prolonged use
  • Allergic reactions such as rash, pruritus, or angioedema
  • Nasal ulceration or perforation
  • Persistent nasal bleeding

Precautions & Warnings

Before using Imidin N 1, consider the following safety measures.

  • Contraindicated in patients with known hypersensitivity to xylometazoline or other imidazoline derivatives.
  • Avoid prolonged use beyond three consecutive days to prevent rebound congestion.
  • Use with caution in individuals with hypertension, cardiovascular disease, diabetes, or thyroid disorders.
  • Pregnant or breastfeeding women should consult a healthcare professional before use.
  • Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Xylometazoline Hydrochloride may interact with other agents that affect blood pressure or vascular tone.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors (MAOIs): risk of hypertensive crisis.
  • Systemic sympathomimetic decongestants: additive vasoconstrictive effect.

Moderate Interactions (Monitor Closely)

  • Antihypertensive medications: possible attenuation of blood‑pressure‑lowering effect.
  • Tricyclic antidepressants: may enhance vasoconstriction.
  • Non‑steroidal anti‑inflammatory drugs (NSAIDs): monitor for increased nasal irritation.

Frequently Asked Questions

Imidin N 1 contains xylometazoline hydrochloride, an over‑the‑counter nasal decongestant used to relieve nasal blockage caused by the common cold, sinusitis and allergic rhinitis by reducing swelling of the nasal mucosa.

Xylometazoline hydrochloride acts as a selective alpha‑adrenergic agonist. It binds to alpha‑receptors on nasal blood vessels, causing vasoconstriction, which limits blood flow and fluid leakage, thereby decreasing mucosal edema and opening the nasal airway.

The appropriate dose of Imidin N 1 is determined by a qualified healthcare professional based on the patient’s age, condition and response. Users should follow the prescriber’s instructions and the product label.

Safety data for xylometazoline hydrochloride in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should consult their healthcare provider before using Imidin N 1.

To order Imidin N 1, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Imidin N 1 (xylometazoline) is an imidazoline‑type decongestant that provides rapid vasoconstriction with a typical onset of action within minutes. Compared with phenylephrine‑based sprays, xylometazoline often offers a longer duration of relief but shares similar cautions regarding rebound congestion with prolonged use.

Imidin N 1 should be stored at ambient temperature, below 25 °C, in its original packaging. Keep the product away from moisture, direct sunlight and extreme heat to maintain its stability and efficacy.

Imidin N 1 is applied intranasally as a spray. The patient should gently blow the nose, insert the nozzle into each nostril, and spray the recommended number of sprays as directed by the prescriber, typically one to two sprays per nostril.

Serious risks include severe hypertension, tachycardia, rebound nasal congestion after prolonged use, and rare allergic reactions such as rash, angioedema or nasal ulceration. Users should discontinue the product and seek medical attention if these events occur.

Individuals with known hypersensitivity to xylometazoline or other imidazoline derivatives, patients with uncontrolled hypertension, severe cardiovascular disease, or those who have experienced rebound congestion from prior nasal decongestant use should avoid Imidin N 1 unless advised otherwise by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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