Product image of Imidin (Xylometazoline Hydrochloride) supplied by GNH India

Imidin

Active Ingredient:
Xylometazoline Hydrochloride
Origin:
EU

Imidin (Xylometazoline Hydrochloride)

Xylometazoline Hydrochloride, the active ingredient in Imidin, is an imidazoline nasal decongestant presented as a nasal formulation for intranasal use. It relieves nasal congestion caused by the common cold, sinusitis and allergic rhinitis in adults and children as directed.
GNH India supplies Imidin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Jadran - Galenski Laboratorij, D.O.O. Ljubljana

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Indications & Clinical Uses

  • Xylometazoline Hydrochloride is an imidazoline nasal decongestant that alleviates congestion in upper‑respiratory conditions.
  • Common cold: reduces nasal blockage and improves breathing.
  • Sinusitis: alleviates sinus‑related congestion and pressure.
  • Allergic rhinitis: diminishes nasal swelling caused by allergens.

How It Works

  • Xylometazoline Hydrochloride acts as a selective α‑adrenergic agonist, binding to α‑1 and α‑2 receptors on the smooth muscle of nasal mucosal blood vessels. This activation induces vasoconstriction, decreasing blood flow and edema in the nasal passages, thereby opening the airway and providing rapid relief of congestion with minimal systemic absorption.

Side Effects

Xylometazoline Hydrochloride may cause local and systemic reactions.

Common Side Effects

  • Nasal irritation or burning sensation.
  • Dryness of the nasal mucosa.
  • Sneezing shortly after application.
  • Mild headache.
  • Altered taste or bitter taste.
  • Transient epistaxis (minor nosebleed).

Serious or Rare Side Effects

  • Severe nasal bleeding.
  • Elevated blood pressure or hypertension.
  • Tachycardia or irregular heartbeat.
  • Allergic reaction (rash, itching, swelling of face or throat).
  • Rebound congestion after prolonged use.
  • Rare cases of ocular hypertension.

Precautions & Warnings

  • When using Imidin, consider the following precautions.
  • Use duration: limit use to 3‑5 days to avoid rebound congestion.
  • Pregnancy: consult a healthcare professional before use.
  • Children: follow age‑specific dosing recommendations on the label.
  • Cardiovascular disease: use with caution in patients with hypertension or heart disease.
  • Drug interactions: avoid concurrent use with other nasal decongestants.
  • Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Xylometazoline Hydrochloride may interact with other medicines.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors: increased risk of systemic vasoconstriction.
  • Other topical nasal decongestants: additive vasoconstrictive effect.

Moderate Interactions (Monitor Closely)

  • Antihypertensive agents: possible reduction in blood‑pressure‑lowering effect.
  • Beta‑blockers: monitor blood pressure and heart rate.
  • Tricyclic antidepressants: may enhance hypertensive response.
  • Certain herbal supplements (e.g., ephedra): increased cardiovascular stimulation.

Frequently Asked Questions

Imidin contains Xylometazoline Hydrochloride and is indicated for temporary relief of nasal congestion associated with the common cold, sinusitis, and allergic rhinitis. It works locally in the nasal passages to reduce swelling and improve airflow. It is an over‑the‑counter product intended for short‑term use in adults and children as directed by a healthcare professional.

Xylometazoline Hydrochloride is a selective α‑adrenergic agonist that binds to α‑1 and α‑2 receptors on the smooth muscle of nasal mucosal blood vessels. Activation causes vasoconstriction, which decreases blood flow, reduces edema, and opens the nasal airway. The effect is localized, with minimal systemic absorption when used as directed.

The specific dose of Imidin is determined by the prescribing healthcare professional based on the patient’s age, condition, and product formulation. Typically, a few sprays per nostril are administered, not exceeding the maximum daily frequency recommended on the label. Users should follow the instructions provided with the product or by their clinician.

Safety data for Xylometazoline Hydrochloride in pregnancy and lactation are limited. It is classified as a category that should be used only if the potential benefit justifies the potential risk to the fetus or infant. Pregnant or nursing women should consult their healthcare provider before using Imidin.

To place an order, submit an enquiry on the Imidin product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, and will request verification of trade or institutional credentials. The sales team then provides pricing, availability, shipping details and any necessary import documentation.

Imidin’s active ingredient, Xylometazoline Hydrochloride, belongs to the imidazoline class, which provides rapid vasoconstriction of nasal vessels. Compared with phenylephrine‑based sprays, Xylometazoline often offers a longer duration of action and may cause less systemic stimulation. However, all topical decongestants share a risk of rebound congestion if used beyond the recommended period.

Imidin should be stored at ambient temperature, preferably below 25 °C, in its original packaging to protect it from moisture and direct sunlight. Keep the container tightly closed when not in use. Do not freeze the product, and keep it out of reach of children.

Imidin is applied intranasally. The user tilts the head slightly forward, inserts the spray tip into one nostril, and depresses the pump to deliver the recommended number of sprays. The same procedure is repeated in the other nostril if required. The spray should be used only as directed on the label or by a healthcare professional.

Although uncommon, serious adverse reactions can occur, including severe nasal bleeding, high blood pressure, rapid heart rate, and allergic reactions such as rash, itching or swelling of the face and throat. If any of these symptoms develop, use should be stopped immediately and medical attention sought. Prolonged use beyond three to five days may also lead to rebound congestion.

Imidin should not be used by individuals who are hypersensitive to Xylometazoline Hydrochloride or any other component of the formulation. It is also contraindicated in patients with severe hypertension, coronary artery disease, or those taking monoamine oxidase inhibitors. Children under the age specified on the product label should not use the spray unless directed by a pediatrician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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