Product image of Imigran Dr (Sumatriptan Succinate) supplied by GNH India

Imigran Dr

Active Ingredient:
Sumatriptan Succinate
Origin:
EU

Imigran Dr (Sumatriptan Succinate)

Sumatriptan succinate, the active ingredient in Imigran Dr, is a Triptan (selective 5‑HT1B/1D receptor agonist) presented as a tablet for oral use. It provides acute treatment of migraine attacks, with or without aura, in adult patients and is indicated for rapid relief of headache and associated symptoms such as nausea, photophobia, and phonophobia.

GNH India supplies Imigran Dr as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, adhering to stringent quality standards and providing reliable logistics for global distribution.

Manufacturer / TM Owner

Glaxosmithkline (Ireland) Limited

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Indications & Clinical Uses

  • Imigran Dr (sumatriptan succinate) is a Triptan used in the acute management of migraine, a neurovascular headache disorder.
  • Migraine with aura: provides rapid relief of headache intensity and associated neurological symptoms.
  • Migraine without aura: reduces pain and associated nausea, photophobia, and phonophobia.
  • Acute migraine attack: aborts the attack when taken at onset, decreasing the need for additional medication.

How It Works

  • Sumatriptan succinate acts as an agonist at serotonin 5‑HT1B and 5‑HT1D receptors located on intracranial blood vessels and trigeminal nerve endings. Activation of these receptors produces cranial vasoconstriction and inhibits the release of pro‑inflammatory neuropeptides, thereby interrupting the cascade that generates migraine pain and associated symptoms.

Side Effects

Common and serious adverse reactions have been reported with sumatriptan use.

Common Side Effects

  • Chest discomfort or tightness
  • Tingling or numbness in fingers or face
  • Flushing or warmth sensation
  • Nausea or mild stomach upset

Serious or Rare Side Effects

  • Coronary vasospasm or myocardial ischemia
  • Severe hypertension or hypertensive crisis
  • Serotonin syndrome, especially with other serotonergic agents

Precautions & Warnings

  • Before prescribing Imigran Dr, clinicians should consider several safety precautions.
  • Cardiovascular assessment: evaluate history of coronary artery disease, uncontrolled hypertension, or stroke.
  • Contraindicated with ergot derivatives: avoid co‑administration due to additive vasoconstriction.
  • Serotonergic drug caution: monitor patients taking SSRIs, SNRIs, or MAO inhibitors for serotonin syndrome.
  • Dose limitation: do not exceed the recommended number of doses per month as advised by the prescriber.
  • Pregnancy and lactation: safety not established; weigh benefits against potential risks.
  • Store at room temperature: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Sumatriptan may interact with several medication classes; awareness of major and moderate interactions helps prevent adverse events.

Major Interactions (Avoid)

  • MAO inhibitors (e.g., phenelzine): risk of severe hypertension and serotonin syndrome.
  • Ergot alkaloids (e.g., ergotamine): additive vasoconstriction may cause coronary spasm.
  • Other triptans or ditans: increased risk of vasospastic events.

Moderate Interactions (Monitor Closely)

  • SSRIs, SNRIs, or TCAs: monitor for signs of serotonin syndrome.
  • CYP3A4 inhibitors (e.g., ketoconazole): may increase sumatriptan plasma levels.

Frequently Asked Questions

Imigran Dr contains sumatriptan succinate and is prescribed for the acute treatment of migraine attacks, both with and without aura. It is intended to relieve headache pain and associated symptoms such as nausea, photophobia, and phonophobia when taken at the onset of an attack.

Sumatriptan is a selective agonist of serotonin 5‑HT1B and 5‑HT1D receptors. By stimulating these receptors on cranial blood vessels and trigeminal nerve endings, it causes vasoconstriction and blocks the release of inflammatory neuropeptides, interrupting the migraine cascade.

The specific dose of Imigran Dr is determined by the prescribing clinician based on the patient’s medical history, severity of migraine, and response to therapy. Dosage may vary, and patients should follow the prescriber’s instructions without self‑adjusting the amount.

Safety data for sumatriptan in pregnancy and lactation are limited. The medication should only be used if the potential benefit justifies any potential risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To order Imigran Dr, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Imigran Dr belongs to the triptan class, which is generally more effective for moderate to severe migraine attacks than simple analgesics. Compared with newer gepants or ditans, triptans have a longer clinical history but share similar contraindications related to vasoconstriction, making patient selection essential.

Imigran Dr tablets should be stored at room temperature, below 25 °C, in their original blister pack. Protect them from moisture, excessive heat and direct sunlight to maintain potency throughout the shelf life.

Imigran Dr is taken orally as a tablet. It should be swallowed whole with a glass of water, preferably as soon as migraine symptoms begin. Patients should not crush, chew, or split the tablet unless specifically instructed by a healthcare provider.

Serious risks include coronary vasospasm, myocardial ischemia, severe hypertension, and serotonin syndrome, especially when combined with other serotonergic agents. Prompt medical attention is required if patients experience chest pain, rapid heartbeat, severe headache, or signs of serotonin toxicity.

Imigran Dr is contraindicated in patients with a history of coronary artery disease, uncontrolled hypertension, severe hepatic impairment, or known hypersensitivity to sumatriptan. It should also be avoided in individuals who have taken ergot derivatives or monoamine oxidase inhibitors within the past 24 hours.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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