Product image of Imigran Radis (Sumatriptan) supplied by GNH India

Imigran Radis

Active Ingredient:
Sumatriptan
Origin:
EU

Imigran Radis (Sumatriptan)

Sumatriptan, the active ingredient in Imigran Radis, is a Triptan presented as an oral tablet for the acute treatment of migraine attacks with or without aura in adults. Approved in the European Union, it targets specific serotonin receptors to produce rapid relief of headache pain, nausea and photophobia.

GNH India supplies Imigran Radis as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies, clinics and other healthcare providers worldwide.

Manufacturer / TM Owner

Glaxosmithkline Oy

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Indications & Clinical Uses

  • Sumatriptan is a Triptan indicated for the acute management of migraine.
  • Migraine with aura: provides rapid relief of headache, nausea, photophobia and phonophobia.
  • Migraine without aura: reduces pain intensity and associated symptoms within hours.
  • Acute migraine in adults: enables patients to achieve pain freedom when taken at the first sign of an attack.

How It Works

  • Sumatriptan acts as a selective agonist at 5‑HT1B and 5‑HT1D receptors located on intracranial blood vessels and trigeminal nerve terminals. Activation of these receptors causes cranial vasoconstriction and inhibits the release of vasoactive neuropeptides, thereby diminishing neurogenic inflammation and interrupting pain transmission pathways involved in migraine.

Side Effects

Common Side Effects

  • Chest tightness or pressure
  • Tingling or numbness in fingers or face
  • Warmth or flushing sensation
  • Dizziness or light‑headedness
  • Nausea or abdominal discomfort
  • Fatigue or drowsiness

Serious or Rare Side Effects

  • Coronary vasospasm or myocardial ischemia
  • Serotonin syndrome, especially with other serotonergic drugs
  • Severe allergic reaction (anaphylaxis, angioedema)
  • Hypertension or hypertensive crisis
  • Cardiac arrhythmias
  • Stroke or transient ischemic attack

Precautions & Warnings

  • Before initiating therapy, evaluate cardiovascular risk and contraindications.
  • Assess cardiovascular risk: confirm no history of ischemic heart disease or uncontrolled hypertension.
  • Avoid use with MAO inhibitors: discontinue MAO‑I therapy at least 14 days prior.
  • Caution in patients with uncontrolled hypertension: monitor blood pressure closely.
  • Do not exceed recommended dose frequency: follow prescriber guidance on maximum doses per 24 hours.
  • Monitor for signs of serotonin syndrome: educate patients about symptoms.
  • Store at below 25°C: keep in the original pack, protect from moisture and light.

Avoid Interactions

Major Interactions (Avoid)

  • MAO inhibitors: increased risk of serotonin syndrome.
  • Other triptans or ergot derivatives: risk of severe vasospasm.

Moderate Interactions (Monitor Closely)

  • SSRIs, SNRIs, or other serotonergic agents: monitor for serotonin excess.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole): may increase sumatriptan plasma levels.
  • Antihypertensive agents (beta‑blockers, calcium channel blockers): may enhance vasoconstrictive effects.

Frequently Asked Questions

Imigran Radis contains sumatriptan, which is indicated for the acute treatment of migraine attacks with or without aura in adults. It is prescribed to relieve headache pain, nausea, photophobia, and phonophobia when a migraine begins. It is not intended for migraine prevention.

Sumatriptan is a selective 5‑HT1B/1D receptor agonist. By stimulating these serotonin receptors on cranial blood vessels, it causes vasoconstriction and blocks the release of pro‑inflammatory neuropeptides from trigeminal nerve endings, thereby reducing vascular dilation and pain signaling associated with migraine.

The dose of Imigran Radis is determined by the prescribing clinician based on the patient’s medical history, severity of migraine, and regulatory guidelines. Typical oral tablet strengths are 25 mg, 50 mg, or 100 mg, but the exact regimen must be individualized and written on the prescription.

Safety of sumatriptan in pregnancy and lactation has not been fully established. It should only be used if the potential benefit justifies the potential risk to the fetus, and breastfeeding mothers should consult a healthcare professional before use. Clinical decisions are made on a case‑by‑case basis.

To place an order, submit an enquiry on the Imigran Radis product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with other triptans, sumatriptan has a rapid onset of action and is available in multiple oral strengths, making it suitable for early intervention. Non‑triptan options such as NSAIDs or gepants have different mechanisms and may be chosen when triptans are contraindicated or ineffective.

Imigran Radis tablets should be stored at below 25 °C in a dry place, protected from moisture and light. Keep the medication in its original packaging until use, and ensure it is out of reach of children. Do not store in bathrooms or near heat sources.

Imigran Radis is taken orally with a glass of water, preferably at the first sign of a migraine attack. The tablet can be swallowed whole; it should not be crushed or chewed. Patients should follow the dosing instructions provided by their prescriber and may repeat the dose after a minimum interval if needed.

Serious risks include coronary vasospasm, myocardial ischemia, and serotonin syndrome, especially when combined with other serotonergic agents. Patients with cardiovascular disease, uncontrolled hypertension, or a history of stroke should be evaluated carefully before use. Immediate medical attention is required if chest pain, severe allergic reaction, or signs of serotonin excess occur.

Imigran Radis is contraindicated in patients with known hypersensitivity to sumatriptan or any component of the formulation, in those with a history of ischemic heart disease, uncontrolled hypertension, peripheral vascular disease, or in individuals who have taken another triptan or ergot derivative within the previous 24 hours. Consultation with a healthcare professional is essential.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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