Product image of Imigran S.C. (Sumatriptan) supplied by GNH India

Imigran S.C.

Active Ingredient:
Sumatriptan
Origin:
EU

Imigran S.C. (Sumatriptan)

Sumatriptan, the active ingredient in Imigran S.C., is a selective serotonin (5‑HT1B/1D) receptor agonist presented as a subcutaneous injection for subcutaneous use. It treats acute migraine attacks, including migraine with aura, in adults.

GNH India supplies Imigran S.C. as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Glaxosmithkline B.V.

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Indications & Clinical Uses

  • Sumatriptan is used to treat acute migraine attacks by targeting the serotonergic pathway.
  • Migraine without aura: provides rapid relief of headache pain and associated symptoms.
  • Migraine with aura: aborts the headache phase after aura onset.
  • Acute episodic migraine: reduces the need for additional rescue medication.

How It Works

  • Sumatriptan acts as an agonist at 5‑HT1B and 5‑HT1D receptors located on intracranial blood vessels and trigeminal nerve endings. Activation causes cranial vasoconstriction and inhibits the release of pro‑inflammatory neuropeptides such as CGRP, thereby interrupting the migraine cascade and alleviating headache.

Side Effects

Common Side Effects

  • Injection site pain
  • Chest discomfort
  • Flushing
  • Nausea
  • Dizziness

Serious or Rare Side Effects

  • Serotonin syndrome
  • Coronary vasospasm
  • Severe hypertension
  • Anaphylactic reaction

Precautions & Warnings

When prescribing Imigran S.C., consider the following precautions:

  • Assess cardiovascular history: avoid use in patients with ischemic heart disease.
  • Review concomitant serotonergic drugs: risk of serotonin syndrome.
  • Avoid in uncontrolled hypertension: monitor blood pressure closely.
  • Use caution in patients with hemiplegic or basilar migraine.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Sumatriptan may interact with several drug classes.

Major Interactions (Avoid)

  • MAO inhibitors: increased risk of severe vasospasm.
  • Ergot derivatives: additive vasoconstrictive effects.
  • Other triptans: heightened chance of serotonin syndrome.

Moderate Interactions (Monitor Closely)

  • SSRIs/SNRIs: monitor for signs of serotonin syndrome.
  • Antihypertensives: may enhance blood pressure lowering effects.

Frequently Asked Questions

Imigran S.C. contains sumatriptan and is indicated for the acute treatment of migraine attacks, including migraine with aura, in adult patients.

Sumatriptan binds to 5‑HT1B and 5‑HT1D receptors, causing constriction of intracranial blood vessels and blocking the release of inflammatory neuropeptides, which together interrupt the migraine cascade.

The prescribed dose of Imigran S.C. is determined by the treating physician based on the patient’s clinical condition and response; dosing instructions are not provided here.

Safety of sumatriptan in pregnancy and lactation has not been fully established. Prescribers should weigh potential benefits against risks and consider alternative therapies when appropriate.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain if needed) and import documentation.

Imigran S.C. is a rapid‑acting injectable triptan, offering faster onset than oral tablets. Compared with other triptans, its subcutaneous route bypasses gastrointestinal absorption, which can be advantageous during severe nausea.

Imigran S.C. should be stored at 2‑8 °C, protected from light, and must not be frozen or shaken. Keep the product in its original packaging until use.

The medication is given as a single subcutaneous injection, typically into the thigh or abdomen, by a healthcare professional or trained individual following aseptic technique.

Serious risks include serotonin syndrome, coronary vasospasm, severe hypertension, and rare anaphylactic reactions. Patients should seek immediate medical attention if they experience chest pain, severe headache, or allergic symptoms.

Imigran S.C. is contraindicated in patients with known hypersensitivity to sumatriptan, uncontrolled hypertension, ischemic heart disease, peripheral vascular disease, or a history of hemiplegic or basilar migraine.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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