Product image of Imipenem/Cilastatin Teva (Cilastatin, Imipenem) supplied by GNH India

Imipenem/Cilastatin Teva

Active Ingredient:
Cilastatin, Imipenem
Origin:
EU

Imipenem/Cilastatin Teva (Cilastatin, Imipenem)

Imipenem, the active ingredient in Imipenem/Cilastatin Teva, is a carbapenem antibiotic presented as a sterile powder for reconstitution for intravenous or inhalation use. It treats severe bacterial infections such as complicated intra‑abdominal, urinary tract, skin, and respiratory infections in hospitalized adults.

GNH India supplies Imipenem/Cilastatin Teva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Teva B.V

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Indications & Clinical Uses

Imipenem/Cilastatin is a broad‑spectrum carbapenem used for serious bacterial infections affecting various organ systems.

  • Complicated intra‑abdominal infections: provides bacterial eradication and clinical cure in mixed aerobic‑anaerobic infections.
  • Complicated urinary tract infections: eliminates resistant uropathogens to achieve microbiological clearance.
  • Skin and soft‑tissue infections: treats severe cellulitis and wound infections caused by susceptible organisms.
  • Bacterial pneumonia: delivers rapid bactericidal activity against common respiratory pathogens.
  • Febrile neutropenia: offers empiric coverage for high‑risk neutropenic patients with suspected infection.

How It Works

  • Imipenem binds to penicillin‑binding proteins, inhibiting the final stages of bacterial cell‑wall peptidoglycan synthesis, which leads to cell lysis. Cilastatin co‑administers to inhibit renal dehydropeptidase I, preventing enzymatic degradation of imipenem and extending its plasma concentration and antibacterial activity.

Side Effects

Adverse reactions may occur with any antimicrobial therapy and should be monitored.

Common Side Effects

  • Nausea
  • Vomiting
  • Diarrhea
  • Headache
  • Infusion‑site phlebitis
  • Elevated liver enzymes

Serious or Rare Side Effects

  • Seizures, especially in patients with renal impairment
  • Anaphylactic or severe allergic reactions
  • Clostridioides difficile‑associated colitis
  • Acute renal toxicity
  • Thrombocytopenia
  • Neutropenia

Precautions & Warnings

Use of Imipenem/Cilastatin requires careful assessment of patient risk factors and clinical monitoring.

  • Renal function assessment: adjust dose in patients with reduced creatinine clearance.
  • Seizure risk: avoid in patients with a history of seizures or CNS disorders.
  • Hypersensitivity: discontinue if signs of an allergic reaction appear.
  • Elderly patients: monitor for neurotoxicity and renal changes.
  • Concomitant valproic acid: anticipate reduced seizure control.
  • Store at below 25°C: keep in original packaging, protect from moisture and light.

Avoid Interactions

Imipenem/Cilastatin can interact with several medicines, influencing efficacy or safety.

Major Interactions (Avoid)

  • Valproic acid: may reduce antiepileptic effect, increasing seizure risk.
  • Probenecid: can raise imipenem plasma levels, heightening toxicity.
  • Cyclosporine: increased neurotoxic potential.

Moderate Interactions (Monitor Closely)

  • Diuretics: may exacerbate renal impairment.
  • NSAIDs: potential additive nephrotoxicity.
  • Anticoagulants (e.g., warfarin): monitor coagulation parameters.
  • Aminoglycosides: increased risk of nephro‑ and ototoxicity.

Frequently Asked Questions

Imipenem/Cilastatin Teva is indicated for severe bacterial infections such as complicated intra‑abdominal infections, complicated urinary tract infections, skin and soft‑tissue infections, bacterial pneumonia, and febrile neutropenia in hospitalized patients.

Imipenem inhibits bacterial cell‑wall synthesis by binding to penicillin‑binding proteins, causing cell lysis. Cilastatin blocks renal dehydropeptidase I, preventing rapid breakdown of imipenem and maintaining therapeutic drug levels.

The prescribed dose of Imipenem/Cilastatin Teva is determined by the treating physician based on infection severity, renal function, and patient characteristics. Dosage regimens are individualized and should follow the prescriber’s instructions.

Safety data for Imipenem/Cilastatin in pregnancy and lactation are limited, and the pregnancy category is unknown. It should only be used if the potential benefit justifies any potential risk to the fetus or infant, and under medical supervision.

To order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and necessary import documentation.

Imipenem/Cilastatin offers a broad spectrum of activity similar to other carbapenems but includes cilastatin to protect against renal degradation, allowing higher and more sustained plasma concentrations. This can provide an advantage in treating infections caused by resistant organisms.

Store the product at temperatures below 25 °C, in its original container, protected from moisture and light. Reconstituted solutions should be used promptly according to the manufacturer’s stability guidelines.

Imipenem/Cilastatin is supplied as a sterile powder for reconstitution and is administered by intravenous infusion or inhalation, as directed by the healthcare professional. The route and infusion rate are determined by the clinical situation.

Serious risks include seizures, especially in patients with renal impairment, severe allergic reactions such as anaphylaxis, Clostridioides difficile‑associated colitis, and acute renal toxicity. Prompt medical attention is required if any of these occur.

Patients with a known hypersensitivity to imipenem, cilastatin, or other carbapenems should avoid this medication. Caution is also advised for individuals with a history of seizures, severe renal impairment, or those receiving valproic acid without appropriate monitoring.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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