Product image of Imipramin Neuraxpharm (Imipramine Hydrochloride) supplied by GNH India

Imipramin Neuraxpharm

Active Ingredient:
Imipramine Hydrochloride
Origin:
EU

Imipramin Neuraxpharm (Imipramine Hydrochloride)

Imipramine Hydrochloride, the active ingredient in Imipramin Neuraxpharm, is a tricyclic antidepressant presented as an oral tablet for oral use. It is prescribed for the treatment of depressive disorders and related conditions in adult patients.

GNH India supplies Imipramin Neuraxpharm as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Neuraxpharm Arzneimittel Gmbh

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Indications & Clinical Uses

Imipramin Neuraxpharm, a tricyclic antidepressant, is used in several psychiatric and urological conditions.

  • Depression: alleviates depressive symptoms and improves mood in major depressive disorder.
  • Panic disorder: reduces the frequency and intensity of panic attacks.
  • Nocturnal enuresis (children): decreases nighttime urinary episodes in pediatric patients.

How It Works

  • Imipramine Hydrochloride blocks the reuptake of norepinephrine and serotonin at neuronal synapses, increasing their extracellular concentrations. This enhances monoaminergic neurotransmission, which is associated with mood elevation and anxiolytic effects. The drug also exhibits anticholinergic and antihistaminic activity that contributes to its overall pharmacological profile.

Side Effects

Imipramin Neuraxpharm may cause a range of adverse reactions, which are grouped by frequency and severity.

Common Side Effects

  • Dry mouth: reduced salivation leading to discomfort.
  • Constipation: slowed gastrointestinal motility.
  • Drowsiness: increased sedation, especially after initiation.
  • Weight gain: gradual increase in body weight.

Serious or Rare Side Effects

  • Cardiac arrhythmia: irregular heart rhythm that may be life‑threatening.
  • Seizures: risk of convulsive episodes, particularly in predisposed individuals.
  • Severe hypotension: marked drop in blood pressure causing dizziness or fainting.

Precautions & Warnings

Before prescribing Imipramin Neuraxpharm, clinicians should consider several safety measures.

  • Cardiovascular assessment: evaluate heart disease history due to arrhythmia risk.
  • Suicidal ideation monitoring: watch for worsening mood, especially early in treatment.
  • Elderly caution: increased sensitivity to anticholinergic effects.
  • Discontinuation: avoid abrupt cessation to prevent withdrawal symptoms.
  • Recent myocardial infarction: contraindicated in patients with recent heart attack.
  • Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Imipramin Neuraxpharm can interact with other medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Monoamine oxidase inhibitors (MAOIs): risk of hypertensive crisis.
  • Selective serotonin reuptake inhibitors (SSRIs) or SNRIs: potential serotonin syndrome.
  • CYP2D6 inhibitors (e.g., fluoxetine): increased imipramine plasma levels.

Moderate Interactions (Monitor Closely)

  • Antihistamines or anticholinergics: additive anticholinergic burden.
  • CNS depressants (e.g., benzodiazepines, alcohol): enhanced sedation and respiratory depression.

Frequently Asked Questions

Imipramin Neuraxpharm contains imipramine hydrochloride, a tricyclic antidepressant indicated for major depressive disorder, panic disorder, and nocturnal enuresis in children. It works by increasing the levels of norepinephrine and serotonin in the brain, which helps improve mood and reduce anxiety symptoms.

Imipramine hydrochloride inhibits the reuptake of the neurotransmitters norepinephrine and serotonin at neuronal synapses. By preventing their removal from the synaptic cleft, the drug raises their concentrations, enhancing monoaminergic signaling that is associated with mood elevation and anxiolytic effects.

The appropriate dose of Imipramin Neuraxpharm is determined by the prescribing clinician based on the patient’s condition, age, response to therapy, and tolerability. Dosage adjustments are made individually, and patients should follow the prescriber’s instructions without self‑adjusting the amount.

Safety data for imipramine during pregnancy and lactation are limited. The drug should only be used if the potential benefit justifies any potential risk to the fetus or infant. Healthcare providers must evaluate each case and discuss possible risks with the patient.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Imipramin Neuraxpharm belongs to the tricyclic antidepressant class, which differs from newer agents such as SSRIs and SNRIs. Tricyclics generally have a broader pharmacologic profile, including anticholinergic effects, and may be effective when newer agents are insufficient, but they often require more careful monitoring for side effects.

Imipramin Neuraxpharm should be stored at ambient temperature, below 25 °C, in its original packaging. Protect the product from moisture, excessive heat, and direct sunlight to maintain its stability and potency.

The medication is taken orally, usually as a tablet, with or without food as directed by the prescriber. Swallow the tablet whole with a full glass of water and follow the dosing schedule provided by the healthcare professional.

Serious risks include cardiac arrhythmias, seizures, severe hypotension, and the potential for suicidal thoughts, especially during early treatment or dose changes. Patients should be monitored closely for any cardiovascular symptoms or changes in mood.

Imipramin Neuraxpharm is contraindicated in patients with recent myocardial infarction, known hypersensitivity to imipramine or other tricyclics, and those currently taking monoamine oxidase inhibitors. Caution is also advised for individuals with severe liver disease, glaucoma, or a history of seizures.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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