Imipramine Hydrochloride Essential Pharma (Imipramine Hydrochloride)

The drug inhibits the reuptake of norepinephrine and serotonin into presynaptic neurons, thereby increasing their concentrations in the synaptic cleft. This enhances monoaminergic neurotransmission, which is associated with mood elevation. Additional antagonism at muscarinic, histaminic and α‑adrenergic receptors contributes to its overall pharmacologic profile.

Dosage is individualized by the prescribing clinician based on the patient’s diagnosis, age, response, and tolerability. Treatment typically begins with a low dose that may be gradually increased. Exact dosing regimens are provided in the prescribing information and should not be altered without medical guidance.

Safety data are limited. The medication is generally contraindicated or should be used only when the potential benefit outweighs the risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss alternative therapies with their healthcare provider.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Imipramine affects both norepinephrine and serotonin reuptake, offering a broader mechanism than selective serotonin reuptake inhibitors (SSRIs). This can be advantageous for patients who do not respond to SSRIs, but it is also linked to a higher incidence of anticholinergic and cardiovascular side effects, influencing therapeutic choice.

Store the tablets at ambient temperature, below 25 °C, in the original packaging to protect from moisture and light. Keep the container tightly closed and out of reach of children. No refrigeration is required.

The medication is supplied as oral tablets and taken by mouth, usually with or without food as directed by the prescriber. Swallow the tablet whole with a glass of water; do not crush or chew unless specifically instructed by a healthcare professional.

Serious adverse events include cardiac arrhythmias, especially in patients with pre‑existing heart disease, seizures, and hepatotoxicity. Rarely, severe hypotension, agranulocytosis, or serotonin syndrome may occur, particularly when combined with other serotonergic agents. Immediate medical attention is required if such symptoms develop.

Patients with known hypersensitivity to imipramine or other tricyclic antidepressants, recent myocardial infarction, uncontrolled narrow‑angle glaucoma, severe hepatic impairment, or those currently taking monoamine oxidase inhibitors should avoid this medication unless a specialist determines it is safe.