Product image of Imipramine Kent Pharma Uk (Imipramine Hydrochloride) supplied by GNH India

Imipramine Kent Pharma Uk

Active Ingredient:
Imipramine Hydrochloride
Origin:
EU

Imipramine Kent Pharma Uk (Imipramine Hydrochloride)

Imipramine, the active ingredient in Imipramine Kent Pharma Uk, is a tricyclic antidepressant presented as an oral dosage form for oral use. It is prescribed for the treatment of depressive disorders and related mood conditions in adults.
GNH India supplies Imipramine Kent Pharma Uk as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Kent Pharma Uk Limited

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Indications & Clinical Uses

  • Imipramine is a tricyclic antidepressant that modulates monoamine neurotransmission to treat mood‑related disorders.
  • Depression: reduces depressive symptoms and improves mood in adult patients.
  • Panic disorder: lessens the frequency and severity of panic attacks.
  • Nocturnal enuresis (children): decreases episodes of nighttime bedwetting.

How It Works

  • Imipramine inhibits the reuptake of norepinephrine and serotonin at neuronal synapses, thereby increasing their extracellular concentrations. The elevated monoamine levels enhance neurotransmission in pathways implicated in mood regulation, leading to antidepressant and anxiolytic effects.

Side Effects

Imipramine may cause a range of adverse reactions that vary in frequency and severity.

Common Side Effects

  • Dry mouth
  • Constipation
  • Drowsiness
  • Blurred vision

Serious or Rare Side Effects

  • Cardiac arrhythmia
  • Seizures
  • Severe hypotension

Precautions & Warnings

  • Before initiating therapy, clinicians should consider several safety measures.
  • Monitor cardiac function: obtain baseline ECG and repeat as clinically indicated.
  • Assess for suicidal ideation: especially during the early treatment phase.
  • Avoid abrupt discontinuation: taper the dose under medical supervision.
  • Use cautiously in elderly patients: increased sensitivity to anticholinergic effects.
  • Store at ambient temperature: keep in the original container, protect from moisture and light.

Avoid Interactions

Imipramine can interact with other medicines, requiring careful management.

Major Interactions (Avoid)

  • MAO inhibitors: risk of severe hypertensive crisis.
  • SSRIs or other serotonergic agents: potential serotonin syndrome.
  • CYP2D6 inhibitors (e.g., fluoxetine, paroxetine): increased plasma concentrations.

Moderate Interactions (Monitor Closely)

  • Alcohol: may enhance central nervous system depression.
  • Antihypertensive drugs: additive hypotensive effect.
  • Anticholinergic medications: heightened anticholinergic burden.

Frequently Asked Questions

Imipramine Kent Pharma Uk contains the tricyclic antidepressant imipramine hydrochloride and is used primarily to treat major depressive disorder. It may also be prescribed for panic disorder and, in pediatric patients, for nocturnal enuresis.

Imipramine blocks the reuptake of the neurotransmitters norepinephrine and serotonin, increasing their levels in the synaptic cleft. This enhances monoaminergic signaling in brain circuits that regulate mood, anxiety, and certain autonomic functions.

The specific dose is determined by the prescribing clinician based on the patient’s condition, age, response, and tolerability. Dosage adjustments are made according to clinical guidelines and individual therapeutic needs.

Safety data for imipramine in pregnancy and lactation are limited. The drug should only be used if the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Imipramine belongs to the tricyclic class, which generally has a broader side‑effect profile than newer agents such as selective serotonin reuptake inhibitors (SSRIs). However, it can be effective in patients who do not respond to SSRIs and may offer additional benefits for certain anxiety disorders.

Store at ambient temperature: keep the product below 25 °C in its original packaging, protected from moisture, light, and excessive heat to maintain stability.

The medication is taken orally, usually with a glass of water. It may be prescribed as a tablet or capsule, and patients are advised to follow the prescriber’s instructions regarding timing and whether to take it with food.

Serious risks include cardiac arrhythmias, especially in patients with pre‑existing heart disease, seizures, severe hypotension, and rare cases of agranulocytosis. Prompt medical attention is required if any concerning symptoms arise.

Imipramine is contraindicated in patients with recent myocardial infarction, uncontrolled narrow‑angle glaucoma, severe hepatic impairment, or known hypersensitivity to the drug. It should also be avoided in individuals currently taking monoamine oxidase inhibitors.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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