Product image of Immunine (Human Coagulation Factor Ix) supplied by GNH India

Immunine

Active Ingredient:
Human Coagulation Factor Ix
Origin:
EU

Immunine (Human Coagulation Factor Ix)

Human Coagulation Factor IX, the active ingredient in Immunine, is a coagulation factor presented as a sterile solution for intravenous use. It treats hemophilia B (Factor IX deficiency) in patients who require replacement therapy.

GNH India supplies Immunine as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Takeda Manufacturing Austria Ag

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Immunine is a coagulation factor used to manage disorders of the intrinsic clotting pathway, primarily hemophilia B.

  • Hemophilia B: provides replacement of deficient factor IX to achieve hemostasis.
  • Surgical prophylaxis in hemophilia B: maintains adequate factor IX levels during operative procedures.
  • Routine prophylaxis in severe hemophilia B: reduces frequency of spontaneous bleeding episodes.

How It Works

  • Human Coagulation Factor IX replaces the missing or deficient factor IX in the intrinsic pathway of the coagulation cascade, restoring the conversion of factor X to Xa and enabling formation of a stable fibrin clot.

Side Effects

Immunine may be associated with infusion‑related reactions and other adverse events.

Common Side Effects

  • Infusion site erythema or swelling.
  • Mild fever or chills.
  • Headache.
  • Nausea.
  • Arthralgia.
  • Transient increase in liver enzymes.

Serious or Rare Side Effects

  • Development of inhibitory antibodies (inhibitors) against factor IX.
  • Anaphylactic or severe allergic reactions.
  • Thromboembolic events.
  • Transmission of viral pathogens (rare with recombinant products).
  • Hemolysis.
  • Severe hypertension.

Precautions & Warnings

Before initiating therapy, consider the following precautions.

  • Monitor inhibitor development: test for anti‑factor IX antibodies periodically.
  • Assess thrombosis risk: avoid in patients with a history of thromboembolic disease.
  • Avoid concurrent use of other clotting factor products unless directed.
  • Use aseptic technique during preparation and administration.
  • Pregnancy and breastfeeding: safety unknown; weigh benefits against potential risks.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Immunine can interact with other medications that affect coagulation.

Major Interactions (Avoid)

  • Concomitant procoagulant agents (e.g., activated prothrombin complex concentrates) may increase thrombosis risk.
  • Concurrent anticoagulants (e.g., warfarin, direct oral anticoagulants) may reduce the efficacy of factor IX replacement.
  • Use with immunogenic biologics may heighten inhibitor formation.

Moderate Interactions (Monitor Closely)

  • Aminoglycoside antibiotics may alter plasma factor IX levels.
  • Live vaccines may have an altered immune response.
  • Co‑administration of other plasma‑derived products may require monitoring for additive clotting effects.

Frequently Asked Questions

Immunine is used to replace deficient human coagulation factor IX in patients with hemophilia B (Factor IX deficiency). It restores the intrinsic clotting pathway, helping to control and prevent bleeding episodes.

Human Coagulation Factor IX supplies the missing protein needed for the intrinsic coagulation cascade. By converting factor X to Xa, it enables the generation of thrombin and the formation of a stable fibrin clot, thereby achieving hemostasis.

The dose of Immunine is individualized. The prescribing clinician determines the amount and frequency based on the patient’s factor IX activity level, severity of hemophilia, and clinical situation such as surgery or bleeding episodes.

The safety of Immunine in pregnancy and lactation has not been established. Clinicians must weigh the potential benefits against unknown risks and consider alternative management strategies when possible.

To order Immunine, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain logistics), and necessary import documentation.

Immunine is a factor IX replacement product similar to other plasma‑derived or recombinant factor IX concentrates. Compared with bypassing agents, it directly restores the deficient protein, offering targeted correction of the clotting defect, but choice of therapy depends on inhibitor status, patient preference, and clinical guidelines.

Immunine should be stored at 2‑8 °C (refrigerated). Keep the vials in their original packaging, protect from light, and avoid freezing or shaking the product to maintain stability.

Immunine is administered intravenously. The infusion is performed by a qualified healthcare professional using aseptic technique, with the rate and volume adjusted according to the prescribed dose and patient tolerance.

The most serious risks include the development of inhibitory antibodies against factor IX, severe allergic or anaphylactic reactions, and thromboembolic events. Monitoring for inhibitors and signs of hypersensitivity is essential during therapy.

Immunine is contraindicated in patients with known hypersensitivity to any component of the product. It should also be used with caution in individuals with a history of thromboembolic disease or those who have previously developed inhibitors to factor IX.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.