Product image of Immunoprin (Azathioprine) supplied by GNH India

Immunoprin

Active Ingredient:
Azathioprine
Origin:
EU

Immunoprin (Azathioprine)

Azathioprine, the active ingredient in Immunoprin, is an antimetabolite presented as an oral formulation for oral use. It suppresses immune activity and is employed in organ transplantation, rheumatoid arthritis and inflammatory bowel disease to help control abnormal immune responses.

GNH India supplies Immunoprin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, oncology centres, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Sandoz Pharmaceuticals D.D.

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

Azathioprine is used to modulate immune activity in several chronic conditions:

  • Organ transplantation: helps prevent graft rejection by inhibiting lymphocyte proliferation.
  • Rheumatoid arthritis: reduces joint inflammation and slows disease progression.
  • Inflammatory bowel disease: maintains remission in Crohn's disease and ulcerative colitis by dampening immune‑mediated gut inflammation.

How It Works

  • Azathioprine is converted intracellularly to 6‑mercaptopurine, which interferes with purine nucleotide synthesis. This inhibition reduces DNA, RNA and protein production in rapidly dividing cells, particularly T‑ and B‑lymphocytes, leading to decreased proliferation and overall immunosuppression.

Side Effects

Azathioprine may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Nausea: mild to moderate stomach upset.
  • Fatigue: general feeling of tiredness.
  • Leukopenia: reduced white‑blood‑cell count.
  • Hepatotoxicity: elevated liver enzymes.
  • Rash: skin irritation or itching.

Serious or Rare Side Effects

  • Myelosuppression: severe bone‑marrow suppression leading to anemia or infections.
  • Pancreatitis: inflammation of the pancreas causing abdominal pain.
  • Severe hepatic injury: jaundice or liver failure.
  • Opportunistic infections: due to weakened immunity.
  • Malignancy risk: increased long‑term risk of certain cancers.

Precautions & Warnings

Before initiating therapy, several safety considerations are recommended:

  • Baseline labs: obtain complete blood count and liver function tests.
  • Monitoring: schedule regular blood work to detect cytopenias or hepatic changes.
  • Infection risk: advise patients to report fever or signs of infection promptly.
  • Vaccination: avoid live vaccines while on treatment.
  • Pregnancy and lactation: discuss potential risks with a healthcare professional.
  • Store at ambient temperature: keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

Azathioprine interacts with several drug classes that can alter its efficacy or safety.

Major Interactions (Avoid)

  • Allopurinol: may cause severe bone‑marrow suppression.
  • Warfarin: increased anticoagulant effect leading to bleeding.
  • Live vaccines: heightened risk of infection.

Moderate Interactions (Monitor Closely)

  • Ribavirin: additive hematologic toxicity.
  • ACE inhibitors: potential for increased renal impairment.
  • NSAIDs: may exacerbate gastrointestinal irritation.

Frequently Asked Questions

Immunoprin, containing azathioprine, is prescribed to help prevent organ‑transplant rejection, to manage rheumatoid arthritis symptoms, and to maintain remission in inflammatory bowel diseases such as Crohn’s disease and ulcerative colitis. It works by dampening the immune response that drives these conditions.

Azathioprine is metabolized to 6‑mercaptopurine, which blocks the synthesis of purine nucleotides. This limits DNA and RNA production in rapidly dividing cells, especially T‑ and B‑lymphocytes, thereby reducing their proliferation and overall immune activity.

The specific dose of Immunoprin is individualized by the prescribing clinician based on the patient’s condition, weight, renal and hepatic function, and response to therapy. Only a qualified healthcare professional should determine the appropriate dosing regimen.

Safety of azathioprine during pregnancy or lactation is not fully established. Physicians must weigh potential benefits against possible risks to the fetus or infant, and decisions should be made in consultation with a specialist experienced in maternal‑fetal medicine.

To place an order, submit an enquiry on the Immunoprin product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with calcineurin inhibitors such as cyclosporine, azathioprine offers a different mechanism—purine synthesis inhibition—resulting in a distinct side‑effect profile. It is often chosen when long‑term oral therapy is needed, but the choice depends on the clinical scenario and physician judgment.

Immunoprin should be stored at ambient temperature, below 25 °C, in its original packaging. Keep the product away from moisture, direct sunlight, and excessive heat to maintain its stability and potency.

Immunoprin is taken orally, usually as tablets or capsules, with or without food as directed by the prescriber. The exact administration schedule—once daily or divided doses—depends on the individual treatment plan.

The most serious risks include severe bone‑marrow suppression (myelosuppression), which can lead to infections, anemia or bleeding, and rare cases of liver toxicity or pancreatitis. Patients should undergo regular laboratory monitoring to detect these complications early.

Immunoprin is contraindicated in individuals with known hypersensitivity to azathioprine or its metabolites, those with severe liver disease, and patients who are pregnant without specialist advice. It should also be avoided in patients with active, uncontrolled infections.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.