Product image of Immunorho (Human Anti-D Immunoglobulin) supplied by GNH India

Immunorho

Active Ingredient:
Human Anti-D Immunoglobulin
Origin:
EU

Immunorho (Human Anti-D Immunoglobulin)

Human Anti-D Immunoglobulin, the active ingredient in Immunorho, is an Immunoglobulin presented as an injectable solution for intramuscular use. It prevents maternal immune sensitization to the D antigen in Rh‑negative pregnant women, thereby reducing the risk of hemolytic disease of the newborn.

GNH India supplies Immunorho as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Kedrion S.P.A.

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Indications & Clinical Uses

Immunorho, a human anti‑D immunoglobulin, works within the Rh‑D antigen pathway to prevent immune‑mediated complications.

  • Rh‑negative pregnancy: prevents maternal sensitization to RhD antigen, reducing risk of hemolytic disease of the newborn.
  • Neonatal care: given prophylactically to newborns at risk of Rh‑incompatible hemolysis.
  • Post‑partum management: administered after delivery of an Rh‑positive infant to avert alloimmunization.

How It Works

  • Human Anti‑D Immunoglobulin provides passive immunity by binding specifically to RhD‑positive erythrocytes. This coating blocks the fetal red cells from being recognized as foreign by the maternal immune system, thereby preventing the formation of anti‑D antibodies and subsequent hemolytic disease in the fetus or newborn.

Side Effects

Common Side Effects

  • Injection site pain: mild to moderate discomfort at the intramuscular site.
  • Low‑grade fever: transient temperature rise within 24 hours.
  • Headache: mild, self‑limiting.
  • Nausea: occasional mild gastrointestinal upset.

Serious or Rare Side Effects

  • Anaphylaxis: severe allergic reaction requiring immediate medical attention.
  • Hemolysis: rapid destruction of red blood cells.
  • Serum sickness: immune complex–mediated reaction with rash and arthralgia.
  • Acute renal failure: rare but serious impairment of kidney function.

Precautions & Warnings

Immunorho should be used with careful clinical assessment.

  • Rh status verification: confirm maternal Rh‑negative status before administration.
  • IgA deficiency screening: avoid in patients with known IgA deficiency due to risk of severe reactions.
  • Allergy history: assess for prior hypersensitivity to blood products.
  • Concomitant blood products: avoid unless clinically indicated to reduce additive immune load.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Human Anti‑D Immunoglobulin may interact with other agents.

Major Interactions (Avoid)

  • Additional anti‑D immunoglobulins: risk of overdose and immune complex formation.
  • Live vaccines: may interfere with vaccine efficacy.
  • Immunosuppressive monoclonal antibodies: can diminish prophylactic effect.

Moderate Interactions (Monitor Closely)

  • IgA‑containing blood products: heightened risk in IgA‑deficient individuals.
  • Antihistamines: may mask early signs of an allergic reaction.
  • Corticosteroids: could alter immune response to the prophylaxis.

Frequently Asked Questions

Immunorho is a human anti‑D immunoglobulin used to prevent Rh alloimmunization in Rh‑negative pregnant women and to reduce the risk of hemolytic disease of the newborn. It provides passive immunity by neutralizing fetal RhD‑positive red cells that may enter the maternal circulation.

The immunoglobulin binds specifically to the D antigen on Rh‑positive red blood cells. By coating these cells, it blocks the maternal immune system from recognizing them as foreign, thereby preventing the formation of anti‑D antibodies that could cause hemolysis in the fetus or newborn.

The dose of Immunorho is determined by the prescribing clinician based on the patient’s Rh status, gestational age, and clinical guidelines. Healthcare professionals calculate the appropriate volume to achieve effective prophylaxis, and the regimen may vary between antenatal and post‑partum administration.

Immunorho is specifically indicated for use in pregnancy to prevent Rh sensitization. While it is administered to pregnant women, safety data for breastfeeding are limited, and the decision to use the product while nursing should be made by a qualified healthcare provider after weighing potential benefits and risks.

To order Immunorho, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide. After submission, the sales team will verify trade or institutional credentials and respond with pricing, availability, cold‑chain shipping details, and necessary import documentation.

Immunorho contains purified human anti‑D immunoglobulin similar to other licensed anti‑D preparations. Differences may lie in manufacturing origin, concentration, and regulatory approvals. Clinicians typically select a product based on local availability, cost, and specific formulation characteristics such as volume and storage requirements.

Immunorho must be stored refrigerated at 2‑8 °C. Keep the vials in their original packaging, protect them from light, and avoid freezing or shaking. If the product reaches room temperature, it should be returned to controlled refrigeration promptly to maintain potency.

Immunorho is given as an intramuscular injection, usually into the deltoid or gluteal muscle. The administration is performed by a qualified healthcare professional using aseptic technique. The volume injected depends on the prescribed dose and the concentration of the preparation.

The most serious risks include severe allergic reactions such as anaphylaxis, hemolysis, serum sickness, and rare cases of acute renal failure. Patients should be monitored closely after injection for any signs of hypersensitivity, and emergency measures should be available to manage anaphylactic events.

Immunorho should not be given to individuals with a known severe IgA deficiency who have experienced prior reactions to blood products, or to patients with a documented hypersensitivity to human immunoglobulins. It is also contraindicated in patients who have received another anti‑D preparation within a short interval without medical justification.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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