Product image of Immunorho (Human Anti-D Immunoglobulin) supplied by GNH India

Immunorho

Active Ingredient:
Human Anti-D Immunoglobulin
Origin:
EU

Immunorho (Human Anti-D Immunoglobulin)

Human Anti-D Immunoglobulin, the active ingredient in Immunorho, is an immunoglobulin presented as a sterile solution for intramuscular use. It prevents maternal sensitization to the Rh(D) antigen in Rh‑negative pregnant women and reduces the risk of hemolytic disease of the fetus and newborn.

GNH India supplies Immunorho as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals worldwide.

Manufacturer / TM Owner

Kedrion S.P.A.

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Indications & Clinical Uses

Immunorho, a Rh immune globulin, is used to manage Rh‑related immunologic conditions.

  • Rh‑negative pregnancy: prevents maternal immune sensitization to the D antigen.
  • Hemolytic disease of the fetus and newborn (HDFN): reduces the risk of fetal anemia and bilirubin‑induced complications.
  • Obstetric Rh incompatibility: provides passive immunity to avoid immune‑mediated hemolysis in the newborn.

How It Works

  • Human Anti-D Immunoglobulin binds specifically to Rh(D) positive erythrocytes circulating in the maternal bloodstream. By coating these cells, the immunoglobulin masks the D antigen, preventing the maternal immune system from recognizing and producing anti‑D antibodies. This passive immunization blocks the cascade that would otherwise lead to fetal red‑cell destruction in subsequent pregnancies.

Side Effects

Immunorho may cause adverse reactions following intramuscular administration.

Common Side Effects

  • Injection site pain, redness or swelling.
  • Mild fever or chills.
  • Headache.
  • Nausea or transient dizziness.

Serious or Rare Side Effects

  • Anaphylactic or severe allergic reaction.
  • Acute hemolysis.
  • Renal impairment or failure.
  • Serum sickness‑like reaction.
  • Severe hypotension or shock.

Precautions & Warnings

Use of Immunorho requires careful clinical assessment.

  • Pregnancy: administer only when the expected benefit outweighs potential risk.
  • Breastfeeding: evaluate risk to the infant before use.
  • Known hypersensitivity to human immunoglobulins: avoid administration.
  • IgA deficiency: monitor closely for anaphylaxis.
  • Concurrent large‑volume immunoglobulin therapy: consider cumulative fluid load.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Immunorho can interact with other agents affecting immune response or coagulation.

Major Interactions (Avoid)

  • Live vaccines: may reduce vaccine efficacy; avoid simultaneous administration.
  • IgA‑deficient plasma products: increased risk of severe allergic reaction.

Moderate Interactions (Monitor Closely)

  • Anticoagulants: may enhance bleeding at the injection site.
  • Immunosuppressants: could alter the intended passive immunity.
  • Additional blood products: monitor for volume overload and immune complex formation.

Frequently Asked Questions

Immunorho is a Rh immune globulin indicated to prevent maternal sensitization to the Rh(D) antigen in Rh‑negative pregnant women and to reduce the risk of hemolytic disease of the fetus and newborn in subsequent pregnancies.

The immunoglobulin binds to any Rh(D) positive red blood cells that may enter the maternal circulation, masking the D antigen and preventing the mother’s immune system from recognizing and producing anti‑D antibodies, thereby providing passive protection.

The dose of Immunorho is determined by the prescribing clinician based on the patient’s Rh status, gestational age and clinical guidelines. Specific dosing regimens are not disclosed here.

Immunorho is administered to pregnant women to protect the fetus; it is considered safe when the clinical benefit outweighs any potential risk. Limited data are available for breastfeeding, so a risk‑benefit assessment should be performed by the healthcare provider.

To place an order, submit an enquiry on the Immunorho product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including cold‑chain where required) and import documentation.

Immunorho contains purified Human Anti‑D Immunoglobulin and offers comparable efficacy to other licensed Rh immune globulins. Differences may lie in manufacturing processes, concentration, and storage requirements, but clinical outcomes for preventing Rh sensitization are generally similar across products.

Immunorho must be stored at 2‑8 °C, protected from light, and should never be frozen or shaken. Keep the product in its original packaging until use to maintain stability.

Immunorho is given by intramuscular injection, typically into the deltoid or gluteal muscle, by a qualified healthcare professional following aseptic technique.

Serious risks include severe allergic reactions such as anaphylaxis, acute hemolysis, renal impairment, serum‑sickness‑like reactions, and profound hypotension. Immediate medical attention is required if any of these occur.

Patients with a known hypersensitivity to human immunoglobulins, those with IgA deficiency who have experienced prior severe reactions, or individuals for whom the benefit does not outweigh the risk should not receive Immunorho. Clinical judgment is essential.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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