Product image of Imodium N6 (Loperamide Hydrochloride) supplied by GNH India

Imodium N6

Active Ingredient:
Loperamide Hydrochloride
Origin:
EU

Imodium N6 (Loperamide Hydrochloride)

Loperamide Hydrochloride, the active ingredient in Imodium N6, is an opioid receptor agonist presented as an oral tablet for oral use. It treats acute nonspecific diarrhea and traveler’s diarrhea in adults and children over the recommended age.
GNH India supplies Imodium N6 as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Mcneil Healthcare (Ireland) Limited

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Indications & Clinical Uses

  • Loperamide Hydrochloride is used to manage diarrheal conditions that involve increased intestinal motility.
  • Acute nonspecific diarrhea: reduces stool frequency and liquidity, helping restore normal bowel function.
  • Traveler's diarrhea: provides symptomatic relief and aids in maintaining hydration during short‑term travel‑related gastrointestinal upset.

How It Works

  • Loperamide Hydrochloride acts as a peripheral μ‑opioid receptor agonist in the myenteric plexus of the gastrointestinal tract. By binding to these receptors it decreases the release of acetylcholine and other excitatory neurotransmitters, leading to reduced smooth‑muscle contractility, slower intestinal transit, and increased absorption of water and electrolytes, which collectively lessen stool volume and liquidity.

Side Effects

Loperamide Hydrochloride may cause a range of adverse reactions, most of which are mild and reversible.

Common Side Effects

  • Constipation
  • Abdominal cramps or discomfort
  • Nausea
  • Dizziness
  • Dry mouth
  • Headache

Serious or Rare Side Effects

  • Severe constipation leading to bowel obstruction
  • Toxic megacolon, especially in patients with underlying inflammatory bowel disease
  • Allergic reactions such as rash, urticaria, or angioedema
  • Cardiac arrhythmias, including QT interval prolongation
  • Severe abdominal pain or ileus
  • Hepatotoxicity in rare cases

Precautions & Warnings

  • Before using Imodium N6, consider the following safety measures.
  • Assess dehydration: ensure adequate fluid and electrolyte replacement prior to therapy.
  • Avoid use in children under 2 years: contraindicated due to risk of severe side effects.
  • Do not exceed recommended dose: follow prescriber or label instructions precisely.
  • Use with caution in hepatic impairment: monitor for increased systemic exposure.
  • Avoid concurrent use with strong CYP3A4 inhibitors: may raise plasma loperamide levels.
  • Store at ambient temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Loperamide can interact with several medicines; awareness helps prevent adverse outcomes.

Major Interactions (Avoid)

  • Potent CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): increased risk of toxicity.
  • Other antidiarrheal agents (e.g., diphenoxylate, atropine): additive opioid effects.
  • QT‑prolonging drugs (e.g., quinidine, macrolide antibiotics): heightened risk of cardiac arrhythmia.

Moderate Interactions (Monitor Closely)

  • Macrolide antibiotics (e.g., erythromycin, clarithromycin): may raise loperamide concentrations.
  • Antihistamines or other constipating agents: monitor bowel habits for excessive slowing.

Frequently Asked Questions

Imodium N6 contains loperamide hydrochloride and is indicated for the symptomatic relief of acute nonspecific diarrhea and traveler’s diarrhea. It helps reduce stool frequency and liquidity, allowing the body to re‑absorb fluids and maintain hydration during short‑term diarrheal episodes.

Loperamide hydrochloride acts as a peripheral μ‑opioid receptor agonist in the gut. By binding to these receptors it slows intestinal motility, enhances water and electrolyte absorption, and decreases the volume of stool, thereby alleviating diarrhea without affecting the central nervous system.

The appropriate dose of Imodium N6 is determined by a qualified healthcare professional based on the patient’s age, weight, severity of symptoms, and clinical response. Prescribers follow local labeling guidelines and adjust the regimen as needed.

Safety data for loperamide hydrochloride in pregnancy and lactation are limited. Healthcare providers should weigh the potential benefits against possible risks before prescribing Imodium N6 to pregnant or nursing individuals, and consider alternative therapies when appropriate.

To place an order, submit an enquiry on the Imodium N6 product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Imodium N6 (loperamide) is a peripheral opioid agonist that primarily slows gut motility, whereas other agents such as bismuth subsalicylate act by coating the mucosa and reducing inflammation. Loperamide generally provides rapid symptom control but requires caution in patients with certain infections or cardiac risk factors.

Imodium N6 should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in the original packaging, protect them from moisture, heat, and direct sunlight to maintain product stability throughout its shelf life.

Imodium N6 is taken orally, usually with a glass of water. The tablet is swallowed whole and should be used according to the prescriber’s instructions, which may include an initial dose followed by maintenance doses based on symptom control.

Serious risks include severe constipation leading to bowel obstruction, toxic megacolon in patients with underlying inflammatory bowel disease, and cardiac arrhythmias such as QT prolongation, especially when combined with other QT‑prolonging drugs or CYP3A4 inhibitors.

Imodium N6 is contraindicated in children under two years of age, individuals with known hypersensitivity to loperamide, patients with acute dysentery, ulcerative colitis, or bacterial enterocolitis, and those taking strong CYP3A4 inhibitors without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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