Product image of Imodium Plus (Dimeticone, Loperamide Hydrochloride) supplied by GNH India

Imodium Plus

Active Ingredient:
Dimeticone, Loperamide Hydrochloride
Origin:
EU

Imodium Plus (Dimeticone, Loperamide Hydrochloride)

Loperamide hydrochloride and dimethicone, the active ingredients in Imodium Plus, are an opioid receptor agonist and antiflatulent presented as an oral dosage form for oral use. It reduces diarrhea and relieves gas in adults experiencing acute nonspecific or travel‑related diarrhea and gastrointestinal bloating.

GNH India supplies Imodium Plus as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Johnson & Johnson Hellas Consumer Ae

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Indications & Clinical Uses

Imodium Plus, containing loperamide and dimethicone, acts on the gastrointestinal tract to manage diarrheal disorders and intestinal gas.

  • Acute nonspecific diarrhea: provides symptomatic relief by slowing intestinal transit.
  • Traveler's diarrhea: helps control loose stools during short‑term travel‑related episodes.
  • Gastrointestinal gas and bloating: reduces gas bubbles and discomfort through the antiflatulent action of dimethicone.

How It Works

  • Loperamide binds to peripheral µ‑opioid receptors in the intestinal wall, decreasing smooth‑muscle activity and fluid secretion, which slows gastrointestinal motility. Dimethicone lowers the surface tension of gas bubbles in the lumen, allowing coalescence and easier elimination, thereby reducing bloating and discomfort.

Side Effects

Common Side Effects

  • Constipation: reduced bowel movements.
  • Abdominal cramps: mild stomach discomfort.
  • Nausea: feeling of queasiness.
  • Flatulence: increased gas.
  • Dizziness: light‑headed sensation.
  • Headache: mild to moderate pain.

Serious or Rare Side Effects

  • Severe constipation or bowel obstruction: risk of impaction.
  • Toxic megacolon: rare but life‑threatening colonic dilation.
  • Allergic reactions: rash, itching, swelling.
  • Cardiac arrhythmia: rare QT prolongation.
  • Severe skin reactions: Stevens‑Johnson syndrome or toxic epidermal necrolysis.

Precautions & Warnings

Before using Imodium Plus, consider the following precautions:

  • Indication limitation: use only for short‑term relief of acute diarrhea.
  • Infectious diarrhea: avoid if diarrhea is caused by bacterial infection or contains blood.
  • Liver impairment: exercise caution in patients with hepatic dysfunction.
  • Drug interactions: monitor use with CYP3A4 or P‑glycoprotein inhibitors.
  • Pediatric use: not recommended for children under 12 years without medical advice.
  • Store at ambient temperature: keep in the original container, protect from moisture and heat.

Avoid Interactions

Imodium Plus may interact with other medicines. Review the following:

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, erythromycin): may increase loperamide levels.
  • P‑glycoprotein inhibitors (e.g., quinidine, ritonavir): can raise systemic exposure.
  • Other antidiarrheal agents: risk of excessive slowing of gut motility.

Moderate Interactions (Monitor Closely)

  • Anticholinergic drugs: additive constipation.
  • CNS depressants (e.g., benzodiazepines): may enhance drowsiness.
  • Calcium channel blockers: possible increased constipation risk.

Frequently Asked Questions

Imodium Plus is indicated for the short‑term relief of acute nonspecific diarrhea, traveler’s diarrhea, and for reducing gastrointestinal gas and bloating. It helps control loose stools and abdominal discomfort associated with these conditions in adults.

Loperamide acts as an opioid receptor agonist at peripheral µ‑opioid receptors in the intestinal wall. By binding these receptors, it decreases smooth‑muscle activity and fluid secretion, which slows intestinal transit and reduces the frequency of watery stools.

The appropriate dose of Imodium Plus is determined by a qualified healthcare professional based on the individual’s condition, age, and response to therapy. Patients should follow the prescriber’s instructions and the product label.

Safety data for Imodium Plus in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should consult their healthcare provider before using the product to weigh potential benefits against risks.

To order Imodium Plus, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Imodium Plus combines loperamide, a potent µ‑opioid receptor agonist, with dimethicone, an antiflatulent. This dual action not only slows bowel movements but also reduces gas, offering broader symptom relief compared with single‑ingredient loperamide products that address only diarrhea.

Imodium Plus should be stored at ambient temperature, preferably below 25 °C. Keep the product in its original packaging, protect it from moisture and direct heat, and store it out of reach of children.

Imodium Plus is taken orally, usually with a glass of water. The tablet or capsule should be swallowed whole and not chewed or crushed, unless otherwise directed by a healthcare professional.

Serious risks include severe constipation leading to bowel obstruction, toxic megacolon, and rare allergic reactions such as skin rash or Stevens‑Johnson syndrome. If any of these occur, discontinue use and seek immediate medical attention.

Imodium Plus should be avoided in individuals with known hypersensitivity to loperamide or dimethicone, in cases of acute dysentery, bacterial enterocolitis with fever, or when diarrhea is caused by a toxin-producing organism. Children under 12 years should not use it without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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