Product image of Imodium Plus (Dimeticone, Loperamide Hydrochloride) supplied by GNH India

Imodium Plus

Active Ingredient:
Dimeticone, Loperamide Hydrochloride
Origin:
EU

Imodium Plus (Dimeticone, Loperamide Hydrochloride)

Dimeticone and Loperamide Hydrochloride, the active ingredients in Imodium Plus, are an anti‑foaming agent and an opioid receptor agonist presented as an oral formulation for over‑the‑counter use. It provides symptomatic relief of acute diarrhea, travelers' diarrhea and abdominal gas in adults and children.

GNH India supplies Imodium Plus as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Mcneil Healthcare (Ireland) Limited

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Indications & Clinical Uses

Imodium Plus acts on intestinal motility and gas formation to treat common gastrointestinal disturbances.

  • Acute nonspecific diarrhea: reduces stool frequency and improves consistency.
  • Travelers' diarrhea: offers rapid symptom control for individuals on short‑term trips.
  • Abdominal bloating and gas: alleviates discomfort by decreasing gas bubbles in the gut.

How It Works

  • Loperamide activates peripheral μ‑opioid receptors in the myenteric plexus, decreasing peristaltic activity and prolonging intestinal transit time. Dimeticone acts as a surfactant that lowers surface tension of gas bubbles, facilitating their coalescence and expulsion, thereby reducing abdominal distension and flatulence.

Side Effects

Adverse reactions may occur with Imodium Plus and should be monitored.

Common Side Effects

  • Constipation: reduced bowel movements.
  • Nausea: mild stomach upset.
  • Abdominal cramps: intermittent discomfort.
  • Dry mouth: reduced salivation.
  • Dizziness: transient light‑headedness.

Serious or Rare Side Effects

  • Severe constipation or ileus: risk of bowel obstruction.
  • Allergic reactions: rash, itching, swelling.
  • Cardiac arrhythmia: especially with concomitant CYP3A4 inhibitors.
  • Toxic megacolon: rare but life‑threatening colonic dilation.
  • Persistent vomiting: may indicate toxicity.

Precautions & Warnings

Use Imodium Plus with care and observe the following precautions.

  • Do not exceed recommended dose: follow prescriber or label instructions.
  • Caution in hepatic impairment: reduced metabolism may increase drug levels.
  • Avoid in bacterial enterocolitis: may worsen infection.
  • Not for children under 2 years: safety not established.
  • Seek medical advice if symptoms persist beyond 48 hours.
  • Store below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Imodium Plus can interact with other medicines; consider the following.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, erythromycin): may raise loperamide plasma concentrations.
  • QT‑prolonging agents (e.g., quinidine, sotalol): increase risk of cardiac arrhythmia.
  • Other antidiarrheal agents: additive effect on gut motility.

Moderate Interactions (Monitor Closely)

  • Opioid analgesics: may enhance central opioid effects.
  • Anticholinergic drugs: could intensify constipation.
  • Antacids containing aluminum or magnesium: may affect absorption of loperamide.

Frequently Asked Questions

Imodium Plus is indicated for the symptomatic treatment of acute nonspecific diarrhea, travelers' diarrhea, and abdominal bloating or gas. It helps reduce stool frequency, improve stool consistency, and alleviate discomfort caused by excess intestinal gas.

Loperamide binds to peripheral μ‑opioid receptors in the intestinal wall, slowing peristalsis and extending transit time, which reduces stool output. Dimeticone acts as a surfactant that lowers surface tension of gas bubbles, allowing them to merge and be expelled more easily, thus relieving bloating.

The appropriate dose of Imodium Plus is determined by a healthcare professional based on the patient’s age, weight, and severity of symptoms. Patients should follow the prescriber’s instructions or the product label and not exceed the recommended amount.

Safety data for Imodium Plus in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should consult their physician before using the product to weigh potential benefits against any possible risks.

To place an order, submit an enquiry on the Imodium Plus product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Imodium Plus combines loperamide, a widely used opioid‑type antidiarrheal, with dimeticone, an anti‑foaming agent not present in many single‑ingredient products. This dual action offers both stool regulation and gas relief, whereas standard loperamide‑only formulations address only diarrheal symptoms.

Imodium Plus should be stored below 25 °C in a dry environment. Keep the product in its original packaging, protect it from moisture, and store it out of direct sunlight to maintain stability and potency.

Imodium Plus is taken orally, usually with a glass of water. The tablet should be swallowed whole and not chewed or crushed, unless otherwise directed by a healthcare professional.

Serious risks include severe constipation or intestinal obstruction (ileus), toxic megacolon, and rare cardiac arrhythmias, especially when combined with strong CYP3A4 inhibitors. Prompt medical attention is required if symptoms such as severe abdominal pain, vomiting, or irregular heartbeat occur.

Individuals with known hypersensitivity to dimeticone or loperamide, children under two years of age, patients with bacterial enterocolitis, and those taking medications that strongly inhibit CYP3A4 or prolong the QT interval should not use Imodium Plus without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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