Product image of Imolope (Loperamide Hydrochloride) supplied by GNH India

Imolope

Active Ingredient:
Loperamide Hydrochloride
Origin:
EU

Imolope (Loperamide Hydrochloride)

Loperamide Hydrochloride, the active ingredient in Imolope, is an opioid antidiarrheal presented as an oral tablet for oral use. It reduces intestinal motility and water loss, helping manage acute and chronic diarrhea as well as diarrhea‑predominant irritable bowel syndrome in adults.

GNH India supplies Imolope as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to EU quality standards and provides reliable sourcing for regulated markets. Customers benefit from consistent batch release, comprehensive documentation, and responsive technical support.

Manufacturer / TM Owner

Orifarm Generics A/S

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Indications & Clinical Uses

Imolope (loperamide hydrochloride) is used to treat diarrheal conditions by slowing gastrointestinal transit.

  • Acute diarrhea: reduces stool frequency and improves consistency in sudden‑onset watery stools.
  • Chronic diarrhea: helps control persistent loose stools associated with various gastrointestinal disorders.
  • Irritable bowel syndrome with diarrhea: alleviates bowel urgency and frequency in IBS‑D patients.

How It Works

  • Loperamide hydrochloride acts as a peripheral µ‑opioid receptor agonist in the myenteric plexus of the gastrointestinal tract. By binding to these receptors it inhibits acetylcholine release, decreasing smooth‑muscle activity and prolonging intestinal transit time. The slowed motility allows greater absorption of water and electrolytes, resulting in firmer stools. Because it does not readily cross the blood‑brain barrier, central opioid effects are minimal.

Side Effects

Loperamide may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Constipation: hard stools or reduced bowel movements.
  • Abdominal cramps: mild to moderate discomfort.
  • Nausea: feeling of sickness or urge to vomit.
  • Dizziness: light‑headed sensation.

Serious or Rare Side Effects

  • Severe constipation: risk of bowel obstruction.
  • Toxic megacolon: extreme dilation of the colon.
  • Cardiac arrhythmias: irregular heart rhythm, especially with high doses.
  • Allergic reactions: rash, itching, swelling, or anaphylaxis.

Precautions & Warnings

When using Imolope, certain precautions should be observed to ensure safe and effective therapy.

  • Dosage adjustment: reduce dose in patients with hepatic impairment.
  • Underlying disease: avoid in suspected infectious diarrhea caused by invasive bacteria.
  • Fluid balance: maintain adequate hydration to prevent electrolyte disturbances.
  • Age considerations: use with caution in elderly patients due to slower gut motility.
  • Drug interactions: review concomitant medications that may affect cardiac conduction.
  • Store at ambient temperature: keep below 25 °C, protect from moisture and light in the original packaging.

Avoid Interactions

Loperamide can interact with other medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • P-glycoprotein inhibitors (e.g., quinidine, ritonavir): may increase systemic loperamide levels and risk of cardiotoxicity.
  • CYP3A4 inhibitors (e.g., clarithromycin, ketoconazole): can raise plasma concentrations.
  • Other opioid agonists: additive central opioid effects are unlikely but may increase constipation.

Moderate Interactions (Monitor Closely)

  • Antidiarrheal agents (e.g., diphenoxylate): combined effect may cause excessive slowing of gut motility.
  • Anticholinergic drugs: may enhance anticholinergic burden leading to constipation.
  • QT‑prolonging drugs (e.g., macrolide antibiotics): monitor ECG for arrhythmia risk.

Frequently Asked Questions

Imolope contains loperamide hydrochloride and is indicated for the symptomatic relief of acute diarrhea, chronic diarrhea, and diarrhea‑predominant irritable bowel syndrome. It works by slowing intestinal transit, which helps reduce stool frequency and improve stool consistency.

Loperamide acts as a peripheral µ‑opioid receptor agonist in the gut. By binding to receptors in the myenteric plexus it inhibits acetylcholine release, decreasing smooth‑muscle activity, prolonging transit time, and allowing more water to be absorbed, resulting in firmer stools.

The appropriate dose of Imolope is determined by a qualified healthcare professional based on the individual’s condition, age, and response. Typical over‑the‑counter regimens start with a low dose and may be increased as needed, but exact dosing should always follow the prescriber’s instructions.

Safety data for loperamide in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss use with their healthcare provider.

To order Imolope, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Imolope (loperamide) is an opioid‑based antidiarrheal that works peripherally, whereas agents such as diphenoxylate‑atropine combine an opioid with an anticholinergic. Loperamide generally has a lower risk of central opioid effects and is available OTC in many regions, making it a convenient first‑line option for most patients.

Imolope should be stored at ambient temperature, preferably below 25 °C, in its original packaging to protect it from moisture and light. Keep the product out of reach of children and do not use it after the expiry date printed on the label.

Imolope is taken orally, usually with a glass of water. The tablet should be swallowed whole and not chewed or crushed. Dosing intervals and the total number of doses per day are determined by the prescribing clinician based on the severity of symptoms.

Serious risks include severe constipation that can lead to bowel obstruction, toxic megacolon, and cardiac arrhythmias, especially when taken with interacting medications or in overdose. Any signs of abdominal pain, bloating, or irregular heartbeat should prompt immediate medical attention.

Imolope should be avoided in individuals with known hypersensitivity to loperamide, in cases of suspected infectious diarrhea caused by invasive bacteria (e.g., Shigella, Salmonella), and in patients with acute ulcerative colitis or pseudomembranous colitis. Caution is also advised for those with significant hepatic impairment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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