Product image of Imolopesim (Dimeticone, Loperamide Hydrochloride) supplied by GNH India

Imolopesim

Active Ingredient:
Dimeticone, Loperamide Hydrochloride
Origin:
EU

Imolopesim (Dimeticone, Loperamide Hydrochloride)

Dimeticone and Loperamide Hydrochloride, the active ingredients in Imolopesim, are an antifoaming agent and an opioid receptor agonist presented as an oral formulation for use in adults and children with diarrhea and related abdominal discomfort. They work together to reduce intestinal motility and decrease gas bubble surface tension, helping to control loose stools and bloating.

GNH India supplies Imolopesim as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Orifarm Generics A/S

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Indications & Clinical Uses

Imolopesim is an antidiarrheal medication that acts on intestinal motility and gas formation.

  • Diarrhea: reduces stool frequency and improves consistency in acute and chronic cases.
  • Acute gastroenteritis: alleviates loose‑stool symptoms caused by infectious gastroenteritis.
  • Traveler's diarrhea: provides symptomatic relief for short‑term travel‑related loose stools.

How It Works

  • Loperamide hydrochloride activates peripheral μ‑opioid receptors in the gastrointestinal tract, decreasing smooth‑muscle activity and prolonging intestinal transit time. Dimeticone lowers the surface tension of gas bubbles, promoting coalescence and facilitating the release of trapped gas, which reduces abdominal bloating and flatulence.

Side Effects

Common Side Effects

  • Constipation: reduced bowel movements leading to hard stools.
  • Nausea: mild stomach upset after ingestion.
  • Abdominal cramps: occasional discomfort or cramping.
  • Flatulence: transient increase in gas.
  • Dizziness: light‑headed sensation.
  • Dry mouth: reduced salivation.

Serious or Rare Side Effects

  • Severe constipation or bowel obstruction: risk of impaction requiring medical attention.
  • Toxic megacolon: rare but life‑threatening colonic dilation.
  • Allergic reactions: rash, itching, swelling, or anaphylaxis.
  • Cardiac arrhythmias: QT prolongation especially with interacting drugs.
  • Hepatotoxicity: elevated liver enzymes in susceptible individuals.

Precautions & Warnings

Before using Imolopesim, consider the following precautions:

  • Assess hydration status: ensure adequate fluid replacement in patients with active diarrhea.
  • Avoid in bacterial enterocolitis: do not use when infection with invasive bacteria is suspected.
  • Hypersensitivity: discontinue if allergic reactions such as rash or swelling occur.
  • Hepatic impairment: use with caution in patients with liver disease due to altered metabolism.
  • Monitor for constipation: watch for signs of severe constipation or abdominal distension.
  • Store at room temperature: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Imolopesim may interact with other medicines; review the following:

Major Interactions (Avoid)

  • CYP3A4 inhibitors (e.g., ketoconazole, erythromycin): increase loperamide plasma levels.
  • P‑glycoprotein inhibitors (e.g., quinidine, verapamil): raise risk of central opioid effects.
  • Other antidiarrheals: additive reduction of gut motility.
  • QT‑prolonging agents (e.g., macrolide antibiotics): heighten cardiac risk.

Moderate Interactions (Monitor Closely)

  • Opioid analgesics: may enhance opioid‑related side effects.
  • Anticholinergic drugs: could worsen constipation.
  • Antispasmodics: may increase gastrointestinal slowdown.
  • Certain antidepressants (e.g., SSRIs): monitor for serotonin syndrome when combined with high‑dose loperamide.

Frequently Asked Questions

Imolopesim is used to manage diarrhea and associated abdominal discomfort, including symptoms of acute gastroenteritis and traveler’s diarrhea. The combination of dimeticone and loperamide works to slow intestinal transit and reduce gas buildup, providing symptomatic relief.

Loperamide activates peripheral μ‑opioid receptors in the gut, decreasing smooth‑muscle contractions and slowing stool passage. Dimeticone lowers the surface tension of gas bubbles, allowing them to coalesce and be expelled more easily, which reduces bloating and flatulence.

The appropriate dose of Imolopesim is determined by the prescribing healthcare professional based on the patient’s age, weight, severity of symptoms, and clinical condition. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety data for Imolopesim in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and this decision must be made by a qualified healthcare provider.

To order Imolopesim, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Imolopesim combines an opioid receptor agonist (loperamide) with an antifoaming agent (dimeticone), offering both motility reduction and gas relief. Compared with loperamide‑only products, it may provide additional comfort from bloating, while still delivering comparable efficacy in controlling loose stools.

Imolopesim should be stored at room temperature, below 25 °C, in its original packaging. Keep the product away from moisture, direct sunlight, and extreme temperatures to maintain its stability and effectiveness.

Imolopesim is taken orally, usually with a glass of water. The tablet or liquid should be swallowed whole and not chewed or crushed unless specifically instructed by a healthcare professional.

Serious risks include severe constipation leading to bowel obstruction, toxic megacolon, allergic reactions such as rash or anaphylaxis, and cardiac arrhythmias (QT prolongation) especially when combined with interacting medications. Prompt medical attention is required if any of these occur.

Imolopesim should be avoided in patients with known hypersensitivity to dimeticone or loperamide, in cases of bacterial enterocolitis (e.g., Clostridioides difficile infection), and in individuals with a history of severe constipation or intestinal blockage unless directed by a physician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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