Product image of Imolopesim (Dimeticone, Loperamide Hydrochloride) supplied by GNH India

Imolopesim

Active Ingredient:
Dimeticone, Loperamide Hydrochloride
Origin:
EU

Imolopesim (Dimeticone, Loperamide Hydrochloride)

Dimeticone and Loperamide Hydrochloride, the active ingredients in Imolopesim, are antidiarrheal agents presented as an oral tablet for oral use. They are indicated for the relief of acute diarrhea, travel‑related diarrhea, and abdominal discomfort associated with gas in adults and children when appropriate.

GNH India supplies Imolopesim as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Orifarm Generics A/S

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Indications & Clinical Uses

  • Imolopesim is an antidiarrheal combination that targets intestinal motility and gas formation.
  • Acute diarrhea: reduces stool frequency and improves stool consistency.
  • Travel‑related diarrhea: provides rapid symptom control for travelers.
  • Abdominal discomfort associated with gas: alleviates bloating and cramping caused by excess intestinal gas.

How It Works

  • Loperamide Hydrochloride acts as a peripheral μ‑opioid receptor agonist, decreasing intestinal smooth‑muscle activity and fluid secretion, thereby slowing transit time. Dimeticone functions as an anti‑foaming agent that lowers surface tension of gas bubbles, facilitating coalescence and expulsion, which can lessen abdominal distension and discomfort.

Side Effects

Imolopesim may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Constipation: reduced bowel movements.
  • Abdominal cramps: mild to moderate discomfort.
  • Nausea: feeling of queasiness.
  • Flatulence: increased gas.
  • Dry mouth: reduced salivation.
  • Dizziness: light‑headed sensation.

Serious or Rare Side Effects

  • Severe constipation or bowel obstruction: persistent lack of stool passage.
  • Toxic megacolon: extreme dilation of the colon.
  • Cardiac arrhythmias: irregular heart rhythm.
  • Allergic reactions: rash, itching, swelling, or difficulty breathing.
  • Central nervous system depression: marked drowsiness or confusion.
  • Hepatotoxicity: abnormal liver function tests.

Precautions & Warnings

  • Before using Imolopesim, consider the following safety measures.
  • Avoid use in patients with known hypersensitivity to loperamide or dimeticone: discontinue if allergic reaction occurs.
  • Do not exceed recommended duration in acute diarrhea without medical advice: risk of constipation.
  • Caution in patients with severe hepatic impairment: monitor for accumulation.
  • Use with care in children under 12 years: dosage and safety not established.
  • Pregnancy and breastfeeding: consult healthcare professional before use.
  • Store at ambient temperature: keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

Imolopesim can interact with other medicines, affecting its efficacy or safety.

Major Interactions (Avoid)

  • CYP3A4 inhibitors (e.g., ketoconazole, erythromycin): may increase loperamide levels.
  • CNS depressants (e.g., opioids, benzodiazepines): heightened risk of respiratory depression.
  • Anticholinergic agents: may exacerbate constipation.

Moderate Interactions (Monitor Closely)

  • Antidiarrheal agents (e.g., bismuth subsalicylate): additive effect on gut motility.
  • Antifungal azoles (e.g., fluconazole): modest increase in loperamide exposure.
  • Diuretics: monitor electrolyte balance if severe diarrhea resolves rapidly.

Frequently Asked Questions

Imolopesim is indicated for the symptomatic treatment of acute diarrhea, travel‑related diarrhea, and abdominal discomfort associated with excess intestinal gas. It helps reduce stool frequency, improve stool consistency, and relieve bloating or cramping caused by gas.

Loperamide Hydrochloride binds to peripheral μ‑opioid receptors in the gut, slowing intestinal motility and decreasing fluid secretion. Dimeticone acts as an anti‑foaming agent that lowers surface tension of gas bubbles, allowing them to coalesce and be expelled more easily, which reduces abdominal distension.

The specific dose of Imolopesim is determined by the prescribing healthcare professional based on the patient’s age, weight, severity of symptoms, and clinical judgment. Patients should follow the prescriber’s instructions and the product labeling.

Safety data for Imolopesim in pregnancy and lactation are limited. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss potential risks and benefits with their healthcare provider before using the product.

To order Imolopesim, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams worldwide, and will request verification of trade or institutional credentials before providing pricing, availability, shipping details, and any necessary import documentation.

Imolopesim combines loperamide, a potent peripheral opioid that slows gut transit, with dimeticone, an anti‑foaming agent that reduces gas‑related discomfort. Compared with loperamide‑only products, Imolopesim may offer additional relief of bloating, while maintaining similar efficacy for diarrhea control.

Imolopesim should be stored at ambient temperature, below 25 °C. Keep the tablets in the original packaging, protect them from moisture, heat, and direct sunlight to maintain product stability.

Imolopesim is taken orally, usually with a glass of water. The tablet should be swallowed whole and not chewed or broken, unless otherwise directed by a healthcare professional.

Serious risks include severe constipation leading to bowel obstruction, toxic megacolon, and rare cardiac arrhythmias. Patients should seek immediate medical attention if they experience persistent abdominal pain, inability to pass stool, or signs of an allergic reaction such as swelling or difficulty breathing.

Imolopesim should be avoided in individuals with known hypersensitivity to loperamide, dimeticone, or any excipients in the tablet, as well as in patients with acute dysentery, bacterial enterocolitis, or colonic ulceration where slowing gut motility could worsen the condition.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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