Product image of Imovane (Zopiclone) supplied by GNH India

Imovane

Active Ingredient:
Zopiclone
Origin:
EU

Imovane (Zopiclone)

Zopiclone, the active ingredient in Imovane, is a cyclopyrrolone presented as a tablet for oral use. It is prescribed for the short‑term management of insomnia in adults.
GNH India supplies Imovane as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Sanofi Oy

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Indications & Clinical Uses

  • Zopiclone is a sedative‑hypnotic that acts on the central nervous system to treat sleep disorders.
  • Insomnia (sleep onset): helps reduce the time needed to fall asleep.
  • Insomnia (sleep maintenance): decreases the number of nocturnal awakenings.
  • Transient insomnia due to stress: improves overall sleep quality.

How It Works

  • Zopiclone binds to the benzodiazepine site of the GABA_A receptor complex as a positive allosteric modulator, enhancing the influx of chloride ions. This potentiates GABA‑mediated inhibitory neurotransmission, leading to reduced neuronal excitability and producing sedative‑hypnotic effects that facilitate sleep initiation and maintenance.

Side Effects

Zopiclone may cause a range of adverse reactions, which are categorized by frequency.

Common Side Effects

  • Drowsiness or excessive sleepiness.
  • Dry mouth.
  • Bitter or metallic taste.
  • Headache.
  • Dizziness.
  • Mild gastrointestinal discomfort.

Serious or Rare Side Effects

  • Allergic reactions such as rash, itching, or swelling.
  • Severe skin reactions (e.g., Stevens‑Johnson syndrome).
  • Mood changes including depression or suicidal thoughts.
  • Unusual thoughts or behaviors (e.g., sleep‑walking, hallucinations).
  • Amnesia or memory impairment.
  • Respiratory depression when combined with other CNS depressants.

Precautions & Warnings

  • Before prescribing Zopiclone, clinicians should consider several safety factors.
  • Use in elderly: increased sensitivity to sedative effects, risk of falls.
  • Avoid alcohol: additive central nervous system depression.
  • Renal impairment: dose adjustment may be required.
  • History of depression or mood disorders: monitor for worsening symptoms.
  • Pregnancy and lactation: safety not established; use only if clearly needed.
  • Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Zopiclone can interact with other medicines, affecting its safety and efficacy.

Major Interactions (Avoid)

  • Alcohol: additive CNS depression leading to profound sedation.
  • Opioids: increased risk of respiratory depression and profound sedation.
  • Benzodiazepines: excessive sedation and impaired psychomotor performance.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inhibitors (e.g., ketoconazole, erythromycin): may raise plasma concentrations.
  • CYP3A4 inducers (e.g., rifampicin, carbamazepine): may reduce therapeutic effect.
  • Antidepressants (e.g., SSRIs, SNRIs): may increase risk of abnormal thoughts or behaviors.

Frequently Asked Questions

Imovane contains the active ingredient Zopiclone and is used as a prescription sedative‑hypnotic to treat short‑term insomnia in adults, helping patients fall asleep faster and stay asleep through the night.

Zopiclone acts as a positive allosteric modulator at the benzodiazepine binding site of the GABA_A receptor. By enhancing GABA‑mediated chloride influx, it increases neuronal inhibition, producing a calming effect that facilitates sleep initiation and maintenance.

The appropriate dose of Imovane is determined by the prescribing healthcare professional based on the individual’s clinical condition, age, renal function, and other factors. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Safety of Zopiclone in pregnancy or while breastfeeding has not been firmly established. It should only be used if the potential benefit justifies the potential risk, and the decision must be made by a qualified healthcare provider.

To place an order, submit an enquiry on the Imovane product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Imovane (Zopiclone) belongs to the cyclopyrrolone class, offering a rapid onset of action and a relatively short half‑life compared with many benzodiazepines. This profile can reduce next‑day residual sedation, but individual response and safety considerations differ among agents, so clinicians choose based on patient needs and risk factors.

Imovane tablets should be stored at ambient temperature, preferably below 25 °C. Keep them in the original packaging, protect from moisture and direct sunlight, and ensure they are out of reach of children.

Imovane is taken orally, usually as a whole tablet, shortly before bedtime. Patients should swallow the tablet with a glass of water and avoid taking it with or after a heavy meal that might delay absorption.

Serious risks include severe allergic reactions, mood changes such as depression or suicidal thoughts, abnormal behaviors like sleep‑walking or hallucinations, and respiratory depression when combined with other central nervous system depressants.

Imovane is contraindicated in individuals with known hypersensitivity to Zopiclone or any cyclopyrrolone, patients with severe hepatic impairment, and those who have experienced complex sleep‑related behaviors with similar agents. Caution is also advised for the elderly and patients with a history of substance misuse.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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