Product image of Imovane (Zopiclone) supplied by GNH India

Imovane

Active Ingredient:
Zopiclone
Origin:
EU

Imovane (Zopiclone)

Zopiclone, the active ingredient in Imovane, is a cyclopyrrolone presented as an oral tablet for oral use. It treats short‑term insomnia in adults by facilitating sleep onset and maintenance.

GNH India supplies Imovane as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Sanofi Winthrop Industrie

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Indications & Clinical Uses

Zopiclone is a hypnotic agent used in the management of sleep disorders.

  • Insomnia: improves overall sleep quality by reducing time to fall asleep and decreasing nocturnal awakenings.
  • Sleep onset difficulty: shortens the latency to the first sleep episode.
  • Sleep maintenance difficulty: reduces the frequency of early morning awakenings.

How It Works

  • Zopiclone acts as a positive allosteric modulator at the GABA‑A receptor complex, binding to a distinct site and enhancing the inhibitory effect of GABA. This potentiation increases chloride ion influx, leading to neuronal hyperpolarisation and a reduction in central nervous system activity, which promotes sedation and facilitates sleep.

Side Effects

Zopiclone may cause a range of adverse reactions, most of which are dose‑related and transient.

Common Side Effects

  • Drowsiness: feeling unusually sleepy during daytime.
  • Dry mouth: reduced salivary flow causing oral discomfort.
  • Headache: mild to moderate cranial pain.
  • Dizziness: sensation of light‑headedness or unsteadiness.

Serious or Rare Side Effects

  • Complex sleep behaviours: activities such as sleep‑walking or driving while not fully awake.
  • Allergic reactions: rash, itching, swelling, or difficulty breathing.
  • Mood changes: depression, anxiety, or unusual thoughts.
  • Hallucinations: visual or auditory disturbances.
  • Respiratory depression: slowed breathing, particularly when combined with other depressants.

Precautions & Warnings

Before prescribing Zopiclone, clinicians should consider several safety measures.

  • Assess renal function: adjust use in patients with impaired kidney function.
  • Avoid alcohol: concurrent consumption can intensify sedation.
  • Use caution in elderly: increased risk of falls and cognitive impairment.
  • Monitor for dependence: limit duration to the shortest effective period.
  • Do not operate machinery: avoid tasks requiring alertness until drug effects are known.
  • Store at ambient temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Zopiclone can interact with other substances that affect the central nervous system.

Major Interactions (Avoid)

  • Alcohol: additive sedative effect.
  • CNS depressants: enhanced sedation and respiratory depression.
  • Opioids: increased risk of profound CNS depression.
  • Barbiturates: potentiated sedative action.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inhibitors (e.g., erythromycin): may raise plasma levels.
  • Antidepressants (e.g., fluoxetine): can increase sedation.
  • Antihistamines: may augment drowsiness.

Frequently Asked Questions

Imovane contains Zopiclone, which is prescribed for the short‑term treatment of insomnia. It helps patients who have difficulty falling asleep, staying asleep, or waking up too early, improving overall sleep quality during a limited treatment period.

Zopiclone binds to a specific site on the GABA‑A receptor complex, acting as a positive allosteric modulator. By enhancing GABA’s inhibitory action, it increases chloride influx into neurons, leading to reduced neuronal excitability and a sedative effect that facilitates sleep.

The appropriate dose of Imovane is determined by the prescribing clinician based on the patient’s age, medical condition, and response to therapy. Dosage instructions are provided on the prescription label and should be followed exactly as directed.

Safety data for Zopiclone in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To place an order, submit an enquiry on the Imovane product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Imovane (Zopiclone) belongs to the cyclopyrrolone class, offering a rapid onset of action similar to benzodiazepine hypnotics but with a distinct chemical structure. Compared with non‑benzodiazepine agents like zolpidem, Zopiclone may have a slightly longer half‑life, which can be advantageous for maintaining sleep but may increase next‑day residual effects in some patients.

Imovane tablets should be stored at ambient temperature, below 25 °C, in the original container to protect them from moisture and light. Keep the product out of reach of children and do not use after the expiry date indicated on the packaging.

Imovane is taken orally, usually shortly before bedtime. The tablet should be swallowed whole with a glass of water and not be taken with or immediately after a heavy meal, as food can delay absorption. Patients should ensure they have a full night’s sleep opportunity (7‑8 hours) before the next dose.

Serious risks include complex sleep behaviours such as sleep‑walking or driving while not fully awake, allergic reactions, and rare cases of respiratory depression, especially when combined with other central nervous system depressants. Patients should seek immediate medical attention if they experience unusual thoughts, hallucinations, or breathing difficulties.

Imovane is contraindicated in patients with known hypersensitivity to Zopiclone or any excipients, severe hepatic impairment, and those with a history of severe sleep‑related behaviours (e.g., sleep‑walking). Caution is also advised for individuals with uncontrolled narrow‑angle glaucoma, severe respiratory disease, or who are currently using other potent CNS depressants.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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