Product image of Imovane (Zopiclone) supplied by GNH India

Imovane

Active Ingredient:
Zopiclone
Origin:
EU

Imovane (Zopiclone)

Zopiclone, the active ingredient in Imovane, is a cyclopyrrolone presented as an oral tablet for oral use. It is prescribed for the short‑term treatment of insomnia in adults who have difficulty falling or staying asleep.

GNH India supplies Imovane as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Sanofi-Aventis Norge As

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Indications & Clinical Uses

  • Zopiclone is a sedative‑hypnotic that acts on the central nervous system to manage sleep disorders.
  • Insomnia (difficulty falling asleep): helps initiate sleep and reduce sleep latency.
  • Insomnia (difficulty staying asleep): decreases nocturnal awakenings and improves sleep continuity.
  • Insomnia (early morning awakening): extends total sleep time and promotes restorative sleep.

How It Works

  • Zopiclone binds to the benzodiazepine site of the GABA‑A receptor complex as a positive allosteric modulator, enhancing the inhibitory effect of GABA. This increased chloride ion influx hyperpolarises neuronal membranes, leading to reduced neuronal excitability and a sedative‑hypnotic effect that facilitates sleep onset and maintenance.

Side Effects

Common Side Effects

  • Drowsiness or fatigue
  • Metallic or bitter taste in the mouth
  • Dry mouth
  • Headache
  • Dizziness
  • Short‑term memory impairment

Serious or Rare Side Effects

  • Allergic reactions such as rash, itching or swelling
  • Severe skin reactions (e.g., Stevens‑Johnson syndrome)
  • Depression or suicidal thoughts
  • Respiratory depression, especially with other CNS depressants
  • Abnormal heart rhythm or palpitations
  • Severe hypotension or syncope

Precautions & Warnings

Zopiclone should be used with caution and under medical supervision.

  • Assess duration of insomnia: limit use to short‑term periods as advised by a prescriber.
  • Avoid alcohol: concurrent consumption may intensify central nervous system depression.
  • Monitor elderly patients: increased sensitivity may raise fall risk.
  • Caution in hepatic impairment: dose adjustment may be required.
  • Store at ambient temperature: keep in the original pack, protect from moisture and heat.

Avoid Interactions

Zopiclone may interact with other medications that affect the central nervous system.

Major Interactions (Avoid)

  • Alcohol: additive sedation and respiratory depression.
  • Opioids: heightened risk of profound CNS depression.
  • Other sedative‑hypnotics (e.g., benzodiazepines): excessive sedation.

Moderate Interactions (Monitor Closely)

  • CYP3A4 inhibitors (e.g., ketoconazole, erythromycin): may increase plasma concentrations.
  • CYP3A4 inducers (e.g., rifampicin, carbamazepine): may reduce therapeutic effect.
  • Antidepressants (e.g., fluoxetine, sertraline): can enhance sedative properties.

Frequently Asked Questions

Imovane, containing the active ingredient Zopiclone, is prescribed for the short‑term management of insomnia. It helps adults who have difficulty falling asleep, staying asleep, or waking up too early to achieve a more normal sleep pattern.

Zopiclone acts as a positive allosteric modulator at the benzodiazepine binding site of the GABA‑A receptor complex. By enhancing GABA‑mediated chloride influx, it increases neuronal inhibition, producing a calming effect that facilitates sleep onset and maintenance.

The specific dose of Imovane is determined by the prescribing clinician based on the patient’s age, medical history, and severity of insomnia. Typical adult regimens range from low to moderate doses, but the exact amount and frequency must be set by a qualified health professional.

Safety data for Zopiclone in pregnancy and lactation are limited, and the drug is generally avoided unless the potential benefit outweighs the risk. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss alternative sleep‑management options with their healthcare provider.

To request Imovane, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Imovane belongs to the cyclopyrrolone class, offering a sleep‑inducing effect similar to non‑benzodiazepine hypnotics such as zolpidem, but with a slightly longer half‑life. Compared with traditional benzodiazepines, Zopiclone generally has a lower risk of dependence but still requires short‑term use under medical supervision.

Imovane tablets should be stored at ambient temperature, below 25 °C, in their original container to protect them from moisture and light. Keep the product out of reach of children and do not use if the packaging is damaged.

Imovane is taken orally, usually with a glass of water, shortly before bedtime. It should be taken only when the patient can dedicate a full night (7‑8 hours) to sleep, and the tablet should not be split, crushed, or chewed unless specifically instructed by a clinician.

Serious risks include severe allergic reactions, marked depression or suicidal thoughts, respiratory depression—especially when combined with other CNS depressants—and rare skin disorders such as Stevens‑Johnson syndrome. Patients should seek immediate medical attention if any of these symptoms occur.

Imovane is contraindicated in individuals with known hypersensitivity to Zopiclone, severe hepatic impairment, untreated sleep‑apnea syndrome, or those who are pregnant or breastfeeding without a clear medical justification. Elderly patients and those with a history of substance misuse should also avoid use unless closely monitored.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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