Product image of Imovax Polio (Poliovirus (Inactivated) Type 3 (Saukett Strain), Poliovirus (Inactivated) Type 2 (Mef-1 Strain), Po) supplied by GNH India

Imovax Polio

Active Ingredient:
Poliovirus (Inactivated) Type 3 (Saukett Strain), Poliovirus (Inactivated) Type 2 (Mef-1 Strain), Po
Origin:
EU

Imovax Polio (Poliovirus (Inactivated) Type 3 (Saukett Strain), Poliovirus (Inactivated) Type 2 (Mef-1 Strain), Po)

Inactivated poliovirus vaccine, the active ingredient in Imovax Polio, is a vaccine presented as an injectable solution for intramuscular or subcutaneous use. It is used to prevent poliomyelitis caused by poliovirus types 1, 2 and 3 in individuals at risk of infection.

GNH India supplies Imovax Polio as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies, and clinics worldwide, ensuring quality‑controlled distribution and regulatory compliance across global markets, with a focus on timely delivery and cold‑chain management where required.

Manufacturer / TM Owner

Sanofi Winthrop Industrie

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Indications & Clinical Uses

Imovax Polio is an inactivated poliovirus vaccine used in the prevention of poliomyelitis, a viral infection of the nervous system.

  • Poliomyelitis (polio): provides active immunity to prevent infection by poliovirus types 1, 2 and 3.
  • Travel to endemic regions: protects travelers against polio infection when visiting areas with ongoing transmission.
  • Outbreak control: employed in mass vaccination campaigns to halt community spread of poliovirus.

How It Works

  • Imovax Polio contains chemically inactivated poliovirus antigens of types 1, 2 and 3. After intramuscular or subcutaneous injection, the antigens are taken up by antigen‑presenting cells, which display them to T lymphocytes, initiating a humoral immune response that generates neutralising antibodies specific to each poliovirus type, thereby conferring protective immunity.

Side Effects

Common Side Effects

  • Injection site pain: mild to moderate discomfort at the site of administration.
  • Redness or swelling: localized erythema or edema that resolves within a few days.
  • Low‑grade fever: transient temperature rise occurring within 24‑48 hours.
  • Irritability (in children): temporary fussiness or restlessness.
  • Headache: mild headache reported in some recipients.

Serious or Rare Side Effects

  • Anaphylaxis: severe allergic reaction requiring immediate medical attention.
  • Seizures: rare neurologic events reported post‑vaccination.
  • Guillain‑Barré syndrome: extremely rare autoimmune neuropathy.
  • Hypotension: sudden drop in blood pressure following injection.
  • Severe allergic reaction to vaccine components: includes angioedema or bronchospasm.

Precautions & Warnings

Precautions should be observed when administering Imovax Polio.

  • Allergy assessment: avoid use in individuals with severe hypersensitivity to any vaccine component.
  • Immunocompromised patients: evaluate risk‑benefit, although the vaccine is inactivated.
  • Pregnancy: consult a healthcare provider; data are limited, use only if clearly needed.
  • Concurrent vaccines: may be given with other vaccines at separate sites, but monitor for increased reactogenicity.
  • Age considerations: follow recommended immunisation schedule for infants, children, and adults.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Potential interactions with other medicines or biologics should be considered.

Major Interactions (Avoid)

  • Immunoglobulin therapy: may reduce vaccine immunogenicity; avoid simultaneous administration.
  • Live viral vaccines: schedule appropriately; do not give within 4 weeks of each other.

Moderate Interactions (Monitor Closely)

  • Antipyretics (e.g., acetaminophen, ibuprofen): may mask fever, monitor temperature post‑vaccination.
  • Immunosuppressive drugs: may diminish antibody response, assess serologic protection.
  • Other injectable vaccines: co‑administration is generally safe but observe for heightened local reactions.

Frequently Asked Questions

Imovax Polio is an inactivated poliovirus vaccine indicated for the prevention of poliomyelitis caused by poliovirus types 1, 2 and 3. It is administered as part of routine immunisation programmes for children and can be used in adults traveling to or residing in areas where polio remains endemic.

The vaccine contains chemically inactivated (killed) poliovirus particles of three serotypes. After injection, the immune system recognises these antigens, activates T‑cells and stimulates B‑cells to produce neutralising antibodies. These antibodies provide protective immunity without causing disease.

The specific dose and schedule are determined by the prescribing healthcare professional according to national immunisation guidelines. Typically, the vaccine is given as a series of intramuscular injections, but the exact volume and timing are set by the clinician based on age and risk factors.

Safety data for use of Imovax Polio during pregnancy are limited. Healthcare providers should weigh the potential benefits against any unknown risks. The vaccine is not known to be excreted in breast milk, but a clinician’s advice is recommended before administration to pregnant or nursing individuals.

To place an order, submit an enquiry on the Imovax Polio product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams across international markets, verifies trade or institutional credentials, and then provides pricing, availability, cold‑chain shipping details and required import documentation.

Imovax Polio is an inactivated (killed) vaccine, whereas the oral polio vaccine (OPV) contains live attenuated virus. IPV, like Imovax, does not carry a risk of vaccine‑derived poliovirus infection and is preferred in settings where OPV‑related outbreaks are a concern. Both provide immunity, but IPV requires injection and induces primarily humoral immunity.

Imovax Polio must be stored refrigerated at 2 °C to 8 °C. It should be kept in the original packaging to protect from light, must not be frozen, and should not be shaken. Prior to administration, allow the vial to reach room temperature if required, and inspect for particulate matter.

The vaccine is administered by a qualified healthcare professional via intramuscular or subcutaneous injection, typically into the deltoid muscle of the upper arm or the anterolateral thigh in infants. The injection site should be cleaned with an appropriate antiseptic, and the dose is delivered using a sterile needle and syringe.

While most reactions are mild, serious adverse events can include anaphylaxis, severe allergic reactions to vaccine components, seizures, Guillain‑Barré syndrome, and sudden hypotension. Any signs of difficulty breathing, swelling of the face or throat, or a rapid drop in blood pressure after vaccination require immediate medical attention.

Individuals with a known severe allergy to any component of the vaccine, such as gelatin or neomycin, should not receive Imovax Polio. Persons who have experienced a previous severe reaction to an inactivated poliovirus vaccine should also avoid it. In all other cases, the vaccine can be administered after clinical evaluation.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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