Product image of Imovax Polio (Poliovirus (Inactivated) Type 3 (Saukett Strain), Poliovirus (Inactivated) Type 2 (Mef-1 Strain), Po) supplied by GNH India

Imovax Polio

Active Ingredient:
Poliovirus (Inactivated) Type 3 (Saukett Strain), Poliovirus (Inactivated) Type 2 (Mef-1 Strain), Po
Origin:
EU

Imovax Polio (Poliovirus (Inactivated) Type 3 (Saukett Strain), Poliovirus (Inactivated) Type 2 (Mef-1 Strain), Po)

Poliovirus (Inactivated) Type 1 (Mahoney), Type 2 (MEF‑1) and Type 3 (Saukett), the active ingredient in Imovax Polio, is a vaccine presented as a sterile injectable formulation for intramuscular or subcutaneous use. Produced under EU pharmaceutical standards, it induces active immunity that protects individuals of all ages against poliomyelitis.

GNH India supplies Imovax Polio as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company ensures quality assurance, cold‑chain logistics and regulatory compliance for global distribution across multiple continents.

Manufacturer / TM Owner

Sanofi Winthrop Industrie

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Indications & Clinical Uses

Imovax Polio is an inactivated poliovirus vaccine used to prevent poliomyelitis, the disease caused by poliovirus infection.

  • Primary immunization: provides protective immunity in infants and young children as part of the routine childhood vaccination schedule.
  • Booster immunization: restores waning immunity in individuals previously vaccinated, extending protection into adulthood.
  • Travel protection: offers immunity for travelers to regions where poliovirus remains endemic or where outbreaks occur.

How It Works

  • The vaccine contains chemically inactivated whole poliovirus strains (types 1, 2 and 3). After intramuscular or subcutaneous injection, the viral antigens are taken up by antigen‑presenting cells, stimulating a humoral immune response that generates neutralizing antibodies against each poliovirus type. These antibodies prevent viral replication and spread, conferring active immunity without causing disease. Memory B cells are also formed, providing long‑term protection.

Side Effects

Imovax Polio may be associated with local and systemic reactions following injection.

Common Side Effects

  • Pain at injection site: mild to moderate discomfort where the vaccine is administered.
  • Redness: localized erythema around the injection area.
  • Fever: low‑grade temperature rise within 24‑48 hours.
  • Headache: mild headache reported after vaccination.

Serious or Rare Side Effects

  • Anaphylaxis: severe allergic reaction requiring immediate medical attention.
  • Guillain‑Barré syndrome: rare neurological disorder characterized by muscle weakness.
  • Seizures: infrequent occurrence, especially in children with high fever.

Precautions & Warnings

Before administering Imovax Polio, certain precautions should be observed to ensure safety and optimal immunogenic response.

  • Allergy assessment: avoid use in individuals with known hypersensitivity to any vaccine component.
  • Immunocompromised patients: evaluate risk, although the inactivated vaccine is generally safe for this population.
  • Pregnancy considerations: administer only if the potential benefit justifies the potential risk to the fetus.
  • Concomitant vaccines: may be given at separate sites, but avoid simultaneous administration with live vaccines.
  • Store at 2-8°C: keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Imovax Polio has limited drug interaction potential, but certain substances may affect its immunogenicity or safety.

Major Interactions (Avoid)

  • Immunoglobulin therapy: may diminish the antibody response to the vaccine.
  • Blood products: concurrent administration can interfere with vaccine efficacy.

Moderate Interactions (Monitor Closely)

  • Antipyretics: use of acetaminophen or ibuprofen may mask fever, a common post‑vaccination sign.
  • Live viral vaccines: schedule at least 4 weeks apart to avoid immune interference.
  • Corticosteroids: high‑dose therapy may reduce vaccine‑induced immunity.

Frequently Asked Questions

Imovax Polio is an inactivated poliovirus vaccine indicated for the prevention of poliomyelitis. It is administered to individuals who have not been previously immunized, as part of routine childhood immunization schedules, for booster doses in previously vaccinated persons, and for travelers heading to areas where poliovirus transmission persists.

The vaccine contains chemically inactivated whole‑virus particles of poliovirus types 1, 2 and 3. After injection, the viral antigens are processed by antigen‑presenting cells, prompting the immune system to produce neutralizing antibodies and memory B cells. These antibodies block viral replication, providing active protection without causing disease.

The dosing regimen for Imovax Polio is determined by the prescribing healthcare professional based on age, vaccination history, and local immunization guidelines. The prescriber decides the number of doses, the interval between them, and the appropriate route (intramuscular or subcutaneous). No fixed dose can be stated without a medical prescription.

Safety data for Imovax Polio in pregnancy are limited, and the product is classified as pregnancy category unknown. It should be administered only when the expected benefit outweighs any potential risk to the fetus. Breastfeeding is not a contraindication, but mothers should discuss vaccination with their healthcare provider to assess any possible effects on the infant.

To place an order, visit the product page on gnhindia.com, enter the required quantity, and submit the enquiry form. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, cold‑chain shipping details and the necessary import documentation.

Imovax Polio is an inactivated poliovirus vaccine (IPV) that contains all three serotypes, whereas oral poliovirus vaccine (OPV) uses live attenuated strains. IPV does not carry a risk of vaccine‑derived poliovirus and is preferred in settings with high immunization coverage, while OPV is easier to administer orally and induces intestinal immunity. Choice depends on national immunization policies and risk assessment.

The vaccine must be stored in a refrigerator at 2 °C to 8 °C. It should be kept in the original packaging to protect from light, must not be frozen, and should not be shaken vigorously. Prior to administration, allow the vial to reach room temperature for a short period if required by the manufacturer’s instructions.

Imovax Polio is given by a single‑dose injection into the deltoid muscle (intramuscular) or the subcutaneous tissue, as directed by the healthcare professional. The injection site is cleaned with an antiseptic, and the appropriate needle size is selected based on the patient’s age and body habitus. The vaccine is not intended for oral use.

The most serious adverse events reported are severe allergic reactions such as anaphylaxis, Guillain‑Barré syndrome, and, rarely, seizures following high fever. These events are uncommon but require immediate medical attention. Patients should be observed for a short period after vaccination to ensure prompt management if a serious reaction occurs.

Individuals with a documented severe allergy to any component of the vaccine, including the inactivated poliovirus strains, should not be vaccinated. Persons who have experienced a previous anaphylactic reaction to an IPV product should also avoid it. In all other cases, the vaccine can be administered after a risk‑benefit assessment by a qualified clinician.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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