Product image of Implanon (Etonogestrel) supplied by GNH India

Implanon

Active Ingredient:
Etonogestrel
Origin:
EU

Implanon (Etonogestrel)

Etonogestrel, the active ingredient in Implanon, is a progestin presented as a 68 mg subdermal implant (rod) for subcutaneous use. It prevents pregnancy by providing continuous hormonal contraception for women of reproductive age.

GNH India supplies Implanon as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

N.V. Organon

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Indications & Clinical Uses

Implanon is a progestin‑based hormonal contraceptive that acts on the reproductive endocrine system to prevent pregnancy.

  • Contraception: provides up to three years of reliable birth control after a single subdermal insertion.
  • Hormonal birth control: delivers a steady release of etonogestrel to suppress ovulation.
  • Reversible contraception: allows fertility to return promptly after removal of the implant.

How It Works

  • Etonogestrel released from the subdermal rod binds to progesterone receptors, suppressing the hypothalamic‑pituitary‑ovarian axis, which inhibits the mid‑cycle luteinizing hormone surge and prevents ovulation. It also thickens cervical mucus and alters the endometrial lining, creating an environment unfavorable for fertilization and implantation.

Side Effects

Implanon may cause a range of adverse reactions, most of which are mild and transient.

Common Side Effects

  • Irregular vaginal bleeding or amenorrhea
  • Headache
  • Acne or skin changes
  • Weight gain
  • Insertion‑site pain or bruising
  • Breast tenderness

Serious or Rare Side Effects

  • Infection at the insertion site
  • Implant migration or extrusion
  • Severe allergic reaction (anaphylaxis)
  • Deep vein thrombosis or pulmonary embolism
  • Ovarian cyst formation
  • Persistent abdominal pain or pelvic inflammatory disease

Precautions & Warnings

Before initiating Implanon therapy, several safety considerations should be reviewed.

  • Medical evaluation: assess contraindications such as active liver disease or thromboembolic disorders.
  • Pregnancy status: confirm the patient is not pregnant before insertion.
  • Breastfeeding: discuss potential effects on milk production and infant exposure.
  • Drug interactions: review concomitant medications that may reduce contraceptive efficacy.
  • Smoking: advise cessation, especially for women over 35 years of age.
  • Store at ambient temperature below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Implanon can interact with medicines that influence hormone metabolism or plasma protein binding.

Major Interactions (Avoid)

  • Antiepileptic enzyme inducers (e.g., carbamazepine, phenytoin): may markedly reduce etonogestrel levels.
  • Rifampin or rifabutin: can lower hormonal efficacy, increasing risk of unintended pregnancy.
  • St. John’s wort: may decrease contraceptive effectiveness.

Moderate Interactions (Monitor Closely)

  • Certain antibiotics (e.g., tetracycline, metronidazole): possible modest reduction in hormone levels.
  • Antifungal agents (e.g., griseofulvin): may affect hormone metabolism.
  • Herbal supplements (e.g., ginseng, green tea extracts): monitor menstrual patterns and advise additional contraception if needed.

Frequently Asked Questions

Implanon is a subdermal contraceptive implant that provides long‑term, reversible birth control. A single 68 mg rod releases etonogestrel continuously for up to three years, preventing ovulation and reducing the chance of pregnancy in women of reproductive age.

Etonogestrel, the hormone in Implanon, binds to progesterone receptors and suppresses the hypothalamic‑pituitary‑ovarian axis. This blocks the luteinizing hormone surge needed for ovulation, thickens cervical mucus, and alters the endometrium, creating conditions that prevent fertilisation and implantation.

Implanon is supplied as a single 68 mg rod that is inserted subdermally by a trained healthcare professional. The prescriber determines suitability and timing; no additional dosing regimen is required after placement.

Implanon is contraindicated in pregnancy and is classified as pregnancy category X. Women who become pregnant while using the implant should have it removed promptly. Breastfeeding is not an absolute contraindication, but clinicians should discuss potential effects on milk production and infant exposure.

To order Implanon, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India supplies hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and the necessary import documentation.

Compared with daily oral contraceptives, Implanon offers a ‘set‑and‑forget’ approach with no need for daily adherence, and it provides up to three years of protection. Unlike intra‑uterine devices, it does not require uterine placement. Its efficacy is comparable to other progestin implants such as Nexplanon, but the choice depends on patient preference, anatomy and clinical considerations.

Implanon should be stored at ambient temperature below 25 °C, in its original sealed packaging, protected from moisture and direct sunlight. The device must be handled only by qualified personnel trained in subdermal implant insertion and removal to maintain sterility and ensure correct placement.

Implanon is inserted subdermally in the inner side of the upper arm by a qualified healthcare professional. The procedure involves creating a small pocket under the skin, placing the 68 mg rod, and closing the site with a sterile dressing. Removal is performed similarly when the implant reaches the end of its approved duration or if early discontinuation is required.

Serious but rare risks include infection at the insertion site, migration or extrusion of the implant, severe allergic reactions, deep‑vein thrombosis or pulmonary embolism, and ovarian cyst formation. Any signs of persistent abdominal pain, severe swelling, fever, or unusual bleeding should prompt immediate medical evaluation.

Implanon is contraindicated in women who are pregnant, have a known or suspected breast cancer, have active liver disease, have a history of thromboembolic disorders, or have unexplained vaginal bleeding. It should also be avoided in individuals with hypersensitivity to etonogestrel or any component of the implant.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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