Product image of Imuprin (Azathioprine) supplied by GNH India

Imuprin

Active Ingredient:
Azathioprine
Origin:
EU

Imuprin (Azathioprine)

Azathioprine, the active ingredient in Imuprin, is an immunosuppressant presented as a tablet for oral use. It is used to prevent organ transplant rejection and to manage autoimmune diseases such as rheumatoid arthritis, inflammatory bowel disease, and systemic lupus erythematosus.

GNH India supplies Imuprin as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, transplant centres, pharmacies and clinics worldwide. The company adheres to EU quality standards and provides reliable global distribution.

Manufacturer / TM Owner

Remedica Ltd

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Indications & Clinical Uses

Azathioprine is employed in the management of several immune‑mediated conditions and in transplant prophylaxis.

  • Organ transplantation prophylaxis: reduces the risk of acute graft rejection.
  • Rheumatoid arthritis: decreases joint inflammation and slows disease progression.
  • Inflammatory bowel disease (Crohn's disease, ulcerative colitis): helps maintain remission and lowers flare frequency.
  • Systemic lupus erythematosus: controls disease activity and prevents organ damage.

How It Works

  • Azathioprine is a prodrug that is converted intracellularly to 6‑mercaptopurine, which interferes with purine nucleotide synthesis. This inhibition hampers DNA replication, leading to reduced proliferation of rapidly dividing T and B lymphocytes, thereby dampening the immune response.

Side Effects

Azathioprine may cause a range of adverse reactions, from mild to serious.

Common Side Effects

  • Nausea or vomiting.
  • Loss of appetite.
  • Mild leukopenia or neutropenia.
  • Rash or mild skin irritation.
  • Fatigue or general weakness.
  • Elevated liver enzymes.

Serious or Rare Side Effects

  • Severe bone‑marrow suppression leading to pancytopenia.
  • Hepatotoxicity with potential liver failure.
  • Acute pancreatitis.
  • Increased susceptibility to serious infections.
  • Higher long‑term risk of malignancies such as lymphoma.
  • Severe hypersensitivity reactions including Stevens‑Johnson syndrome.

Precautions & Warnings

Careful monitoring and patient education are essential when using azathioprine.

  • Blood count monitoring: perform regular complete blood counts to detect leukopenia.
  • Liver function monitoring: assess hepatic enzymes periodically.
  • Pregnancy safety: avoid use in pregnancy unless benefits outweigh risks; category D.
  • Dose adjustments: modify dose in renal or hepatic impairment as advised by a clinician.
  • Infection risk: counsel patients to report signs of infection promptly.
  • Store at below 25°C: keep in the original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Azathioprine interacts with several medicines that can alter its efficacy or safety.

Major Interactions (Avoid)

  • Allopurinol: may cause severe bone‑marrow suppression.
  • TPMT deficiency (genetic): increases risk of toxicity; test before therapy.

Moderate Interactions (Monitor Closely)

  • Warfarin: azathioprine can enhance anticoagulant effect, requiring INR monitoring.
  • ACE inhibitors: may increase risk of neutropenia.
  • Live vaccines: reduced efficacy and potential infection risk.
  • NSAIDs: additive gastrointestinal irritation and bleeding risk.

Frequently Asked Questions

Imuprin contains azathioprine, which is prescribed to prevent organ transplant rejection and to manage several autoimmune disorders, including rheumatoid arthritis, inflammatory bowel disease (Crohn's disease and ulcerative colitis), and systemic lupus erythematosus.

Azathioprine is converted to 6‑mercaptopurine inside cells, where it blocks purine synthesis. This limits DNA replication in rapidly dividing T and B lymphocytes, suppressing the immune response that drives transplant rejection and autoimmune inflammation.

The specific dose of Imuprin is determined by the prescribing clinician based on the patient’s condition, weight, renal and hepatic function, and response to therapy. Dosage adjustments are made during treatment as needed.

Azathioprine is classified as pregnancy category D, indicating evidence of risk to the fetus. It should only be used during pregnancy if the potential benefit justifies the risk. Limited data are available for breastfeeding; the decision should be made with a healthcare professional.

To request Imuprin, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Azathioprine belongs to the antimetabolite class and differs from calcineurin inhibitors such as cyclosporine or tacrolimus. It is generally taken orally, has a slower onset of action, and may have a different side‑effect profile, including a higher risk of bone‑marrow suppression but lower nephrotoxicity.

Imuprin should be stored at temperatures below 25 °C, in its original container, protected from moisture and direct light. Do not store in a refrigerator or freezer unless the packaging specifically indicates otherwise.

Imuprin is taken orally, usually with food or a glass of water to reduce gastrointestinal irritation. The tablet should be swallowed whole and not crushed or chewed unless directed by a healthcare professional.

Serious risks include severe bone‑marrow suppression leading to pancytopenia, hepatotoxicity, pancreatitis, opportunistic infections, and an increased long‑term risk of certain cancers such as lymphoma. Patients should be monitored regularly for blood counts and liver function.

Imuprin is contraindicated in patients with known hypersensitivity to azathioprine or its metabolites, those with severe hepatic impairment, and individuals with active, uncontrolled infections. It should also be avoided in pregnant women unless the benefit outweighs the risk.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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