Product image of Inalacor (Fluticasone Propionate) supplied by GNH India

Inalacor

Active Ingredient:
Fluticasone Propionate
Origin:
EU

Inalacor (Fluticasone Propionate)

Fluticasone Propionate, the active ingredient in Inalacor, is a corticosteroid presented as an inhalation product for inhalation use. It is employed to reduce airway inflammation in patients with asthma and chronic obstructive pulmonary disease. It is indicated for long‑term maintenance therapy and is delivered via a metered‑dose inhaler designed to ensure consistent particle size.

GNH India supplies Inalacor as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory documentation for export to multiple regions.

Manufacturer / TM Owner

Glaxosmithkline, S.A.

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Indications & Clinical Uses

Inalacor, an inhaled corticosteroid, is used to manage inflammatory airway diseases.

  • Asthma: reduces airway inflammation, improves symptom control and decreases frequency of exacerbations.
  • Chronic obstructive pulmonary disease (COPD): decreases airway inflammation, helps reduce exacerbation risk and improves lung function.
  • Chronic bronchitis (as part of COPD): controls inflammatory processes in the bronchial mucosa, aiding symptom relief.
  • Exercise‑induced bronchoconstriction: provides prophylactic anti‑inflammatory effect to prevent airway narrowing during physical activity.

How It Works

  • Fluticasone Propionate binds to intracellular glucocorticoid receptors in airway epithelial and inflammatory cells. The receptor complex translocates to the nucleus, where it interacts with glucocorticoid response elements, modulating gene transcription. This results in decreased production of pro‑inflammatory cytokines, chemokines, and adhesion molecules, leading to reduced recruitment of eosinophils and other inflammatory cells and suppression of airway edema and hyper‑responsiveness.

Side Effects

Inhaled fluticasone propionate may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Oral thrush (candidiasis): fungal infection of the mouth and throat.
  • Hoarseness or dysphonia: voice changes due to local irritation.
  • Cough or throat irritation: discomfort after inhalation.

Serious or Rare Side Effects

  • Adrenal suppression: reduced endogenous cortisol production.
  • Pneumonia: especially in patients with COPD.
  • Paradoxical bronchospasm: sudden worsening of airway obstruction.

Precautions & Warnings

When prescribing Inalacor, several precautionary measures should be observed to minimize risk and ensure optimal therapy.

  • Assess inhaler technique: verify patient can use the device correctly.
  • Monitor for oral candidiasis: advise rinsing mouth after each use.
  • Evaluate for active tuberculosis: avoid use in uncontrolled TB infection.
  • Use lowest effective dose: limit systemic exposure.
  • Avoid in patients with known hypersensitivity to fluticasone or excipients.
  • Store at room temperature: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Fluticasone propionate can interact with other medicines, affecting its efficacy or safety.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may increase systemic exposure and risk of adrenal suppression.
  • Systemic glucocorticoids (e.g., oral prednisone): additive immunosuppressive effects and heightened adrenal suppression.

Moderate Interactions (Monitor Closely)

  • Ritonavir (HIV protease inhibitor): moderate increase in fluticasone levels.
  • Diuretics (e.g., furosemide): may enhance fluid retention when combined with corticosteroids.
  • β2‑agonists (e.g., albuterol): possible additive bronchodilator effect; monitor for tachycardia.

Frequently Asked Questions

Inalacor contains fluticasone propionate, an inhaled corticosteroid that is prescribed to manage chronic inflammatory airway diseases such as asthma and chronic obstructive pulmonary disease (COPD). It works as a maintenance therapy to reduce airway inflammation, improve symptom control, and lower the risk of exacerbations.

Fluticasone propionate binds to glucocorticoid receptors inside airway cells, forming a complex that moves into the nucleus and influences gene transcription. This action suppresses the production of inflammatory cytokines, chemokines and adhesion molecules, leading to decreased recruitment of eosinophils and other inflammatory cells, thereby reducing airway edema and hyper‑responsiveness.

The dose of Inalacor is individualized by the prescribing clinician based on the severity of the patient’s asthma or COPD, age, and response to therapy. The prescriber determines the number of inhalations per day and may adjust the regimen during follow‑up visits to achieve optimal control while using the lowest effective dose.

Safety data for inhaled fluticasone propionate in pregnancy and lactation are limited. The medication should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant. Healthcare providers usually assess each case and may consider alternative therapies when appropriate.

To place an order, visit the product page on gnhindia.com, enter the required quantity, and submit the enquiry form. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements) and necessary import documentation.

Inalacor delivers fluticasone propionate, which has high topical potency and low systemic bioavailability compared with some other inhaled steroids such as budesonide. This profile allows effective anti‑inflammatory control at relatively low inhaled doses, potentially reducing the risk of systemic side effects while providing comparable efficacy in asthma and COPD maintenance.

Inalacor should be stored at room temperature, below 25 °C, in its original packaging to protect it from moisture and direct sunlight. Keep the inhaler device upright, avoid exposing it to extreme temperatures, and discard any unit that appears damaged or past its expiration date.

Inalacor is delivered via a metered‑dose inhaler. The patient should exhale fully, place the mouthpiece in the mouth, seal lips around it, and press the canister while inhaling slowly and deeply. After each actuation, the patient should hold their breath for about 10 seconds before exhaling gently. Proper technique should be reviewed regularly.

The most serious adverse events include adrenal suppression, which can lead to inadequate stress response; pneumonia, particularly in COPD patients; and paradoxical bronchospasm, a sudden worsening of airway obstruction after inhalation. Patients should be instructed to seek immediate medical attention if they experience severe shortness of breath, unusual fatigue, or signs of infection.

Inalacor is contraindicated in individuals with a known hypersensitivity to fluticasone propionate or any of the inhaler’s excipients. It should also be avoided in patients with active, untreated tuberculosis or other severe infections of the respiratory tract, as the drug’s immunosuppressive effect may exacerbate these conditions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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