Product image of Inantol (Fluticasone Propionate, Salmeterol) supplied by GNH India

Inantol

Active Ingredient:
Fluticasone Propionate, Salmeterol
Origin:
EU

Inantol (Fluticasone Propionate, Salmeterol)

Fluticasone propionate / Salmeterol, the active ingredient in Inantol, is an inhaled corticosteroid / long‑acting β2‑agonist combination presented as an inhalation aerosol for inhalation use. It provides maintenance therapy for asthma and chronic obstructive pulmonary disease in adult patients.
GNH India supplies Inantol as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Viatris Pharmaceuticals, S.L.U.

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Indications & Clinical Uses

  • Inantol is used as a maintenance inhaler targeting chronic respiratory disease pathways, improving lung function and reducing exacerbations.
  • Asthma: helps control symptoms and prevents flare‑ups when used regularly.
  • Chronic obstructive pulmonary disease (COPD): reduces breathlessness and frequency of exacerbations.
  • Bronchospasm prevention: provides long‑acting bronchodilation to maintain open airways in patients requiring combination therapy.

How It Works

  • Fluticasone propionate binds to glucocorticoid receptors in airway cells, suppressing inflammatory gene expression and reducing cytokine production. Salmeterol selectively stimulates β2‑adrenergic receptors, activating adenylate cyclase and increasing cyclic AMP, which relaxes bronchial smooth muscle and sustains bronchodilation for up to 12 hours.

Side Effects

Inhaled corticosteroid/long‑acting β2‑agonist therapy can cause a range of adverse reactions.

Common Side Effects

  • Oral thrush or candidiasis
  • Hoarseness or voice changes
  • Cough or throat irritation
  • Headache
  • Nasal congestion
  • Dry mouth

Serious or Rare Side Effects

  • Paradoxical bronchospasm
  • Adrenal suppression with systemic effects
  • Severe allergic reactions (anaphylaxis)
  • Cardiac arrhythmias or tachycardia
  • Decreased bone mineral density with long‑term use
  • Pneumonia in COPD patients

Precautions & Warnings

  • When prescribing Inantol, clinicians should consider several safety measures.
  • Assess infection risk: monitor for oral candidiasis and treat promptly.
  • Monitor growth in children: long‑term corticosteroid exposure may affect growth velocity.
  • Avoid abrupt discontinuation: taper to prevent adrenal insufficiency.
  • Use mouth rinse after inhalation: reduces local steroid deposition.
  • Check for hypersensitivity: discontinue if allergic reaction occurs.
  • Store at room temperature: keep in original container, protect from moisture and heat.

Avoid Interactions

Inantol may interact with other medicines, requiring careful management.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole) may increase systemic steroid exposure.
  • Non‑selective β‑blockers can blunt bronchodilator response.
  • Diuretics may exacerbate β2‑agonist‑induced hypokalemia.

Moderate Interactions (Monitor Closely)

  • Moderate CYP3A4 inhibitors (e.g., erythromycin, fluconazole) may modestly raise drug levels.
  • Ritonavir and other protease inhibitors can increase exposure.
  • Anticholinergic agents may add to anticholinergic load, affecting airway tone.

Frequently Asked Questions

Inantol is a prescription inhaler that combines fluticasone propionate and salmeterol to provide long‑term maintenance therapy for asthma and chronic obstructive pulmonary disease (COPD). It helps control inflammation and keeps airways open, reducing symptoms and the risk of exacerbations when used regularly as part of a comprehensive treatment plan.

Fluticasone propionate activates glucocorticoid receptors in airway cells, suppressing inflammatory pathways and decreasing mucus production. Salmeterol selectively stimulates β2‑adrenergic receptors, raising cyclic AMP levels that relax bronchial smooth muscle. Together, they reduce airway inflammation and provide sustained bronchodilation for up to 12 hours.

The prescribed dose of Inantol is individualized by a healthcare professional based on the severity of asthma or COPD, patient age, and response to therapy. The prescriber determines the number of inhalations per day and the total daily dose, which should be followed exactly as instructed on the prescription label.

The safety of Inantol in pregnancy and lactation has not been definitively established. It should only be used if the potential benefit justifies any possible risk to the fetus or infant. Women who are pregnant, planning pregnancy, or breastfeeding should discuss the risks and alternatives with their physician.

To request Inantol, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Inantol combines an inhaled corticosteroid with a long‑acting β2‑agonist, offering both anti‑inflammatory and bronchodilator effects in a single device. Compared with single‑component inhalers, it reduces the need for multiple devices, improves adherence, and provides consistent dosing. Alternatives may include separate corticosteroid and LABA inhalers or combination products with different potency or device types.

Inantol should be stored at room temperature, below 25 °C, in its original packaging to protect it from moisture and direct sunlight. Keep the inhaler cap tightly closed when not in use and avoid exposing it to extreme temperatures, which could affect aerosol performance.

Inantol is delivered via an inhalation aerosol device. The patient exhales fully, places the mouthpiece in the mouth, and inhales slowly and deeply while actuating the inhaler. After each inhalation, the patient should hold their breath for about 10 seconds to allow optimal drug deposition, then rinse the mouth to reduce local side effects.

Serious risks include paradoxical bronchospasm, which can worsen breathing difficulty, and systemic effects such as adrenal suppression or severe allergic reactions (anaphylaxis). Patients should be educated to seek immediate medical attention if they experience sudden wheezing, swelling, rash, or signs of infection while using the inhaler.

Inantol is contraindicated in individuals with a known hypersensitivity to fluticasone, salmeterol, or any component of the inhaler formulation. It should also be avoided in patients who have experienced severe paradoxical bronchospasm with similar medications. Clinicians must assess each patient’s medical history before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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