Product image of Inaspir Accuhaler (Salmeterol) supplied by GNH India

Inaspir Accuhaler

Active Ingredient:
Salmeterol
Origin:
EU

Inaspir Accuhaler (Salmeterol)

Salmeterol, the active ingredient in Inaspir Accuhaler, is a long‑acting β2‑adrenergic agonist presented as a 50 µg per inhalation dry‑powder inhaler (Accuhaler) for inhalation use. It provides maintenance bronchodilation for patients with asthma and chronic obstructive pulmonary disease (COPD).

GNH India supplies Inaspir Accuhaler as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies, clinics and other healthcare facilities worldwide.

Manufacturer / TM Owner

Glaxosmithkline, S.A.

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Indications & Clinical Uses

Salmeterol is a long‑acting bronchodilator that acts on the β2‑adrenergic pathway to improve airflow in chronic respiratory diseases.

  • Asthma: improves symptom control and reduces the frequency of exacerbations when used as maintenance therapy.
  • Chronic obstructive pulmonary disease (COPD): provides sustained bronchodilation to enhance lung function and exercise tolerance.

How It Works

  • Salmeterol selectively binds to β2‑adrenergic receptors on bronchial smooth‑muscle cells, activating adenylate cyclase and increasing intracellular cyclic AMP. The rise in cAMP leads to relaxation of the smooth muscle, producing prolonged bronchodilation that can last up to 12 hours after inhalation. Its high lipophilicity allows the drug to remain associated with the receptor site, sustaining the therapeutic effect between doses.

Side Effects

Common and serious adverse reactions have been reported with Salmeterol inhalation.

Common Side Effects

  • Throat irritation or dryness
  • Cough
  • Headache
  • Tremor
  • Palpitations
  • Muscle cramps

Serious or Rare Side Effects

  • Paradoxical bronchospasm
  • Severe allergic reaction (anaphylaxis)
  • Cardiac arrhythmia
  • Chest pain or angina
  • Hypokalemia
  • Acute worsening of asthma symptoms

Precautions & Warnings

When prescribing or using Inaspir Accuhaler, several safety considerations should be observed.

  • Assess disease control: confirm that asthma or COPD is not adequately managed with other therapies before initiating.
  • Use as maintenance only: do not rely on Salmeterol for acute symptom relief.
  • Monitor cardiovascular status: observe for tachycardia, palpitations or hypertension during treatment.
  • Avoid concomitant non‑selective β‑blockers: they may diminish bronchodilator efficacy.
  • Review concomitant medications: consider potential interactions with diuretics or theophylline.
  • Store at below 25°C: keep in the original packaging, protect from moisture and heat.

Avoid Interactions

Salmeterol may interact with other medicines, altering its effectiveness or safety profile.

Major Interactions (Avoid)

  • Non‑selective β‑blockers: can block the bronchodilatory action of Salmeterol.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole): may increase systemic exposure and risk of adverse effects.
  • Monoamine oxidase inhibitors: concurrent use may increase the risk of severe bronchospasm.

Moderate Interactions (Monitor Closely)

  • Diuretics: may potentiate hypokalemia, especially when combined with β2‑agonist activity.
  • Theophylline: additive stimulant effects on the cardiovascular system may occur.
  • Other long‑acting β2‑agonists or LABA‑containing combinations: increase the likelihood of overlapping side effects.

Frequently Asked Questions

Inaspir Accuhaler contains Salmeterol, a long‑acting β2‑adrenergic agonist that is used as a maintenance inhalation therapy to improve breathing in adults with asthma and in patients with chronic obstructive pulmonary disease (COPD). It is not intended for immediate relief of acute bronchospasm.

Salmeterol selectively stimulates β2‑adrenergic receptors on bronchial smooth‑muscle cells, activating adenylate cyclase and raising cyclic AMP levels. The increased cAMP causes smooth‑muscle relaxation, leading to prolonged bronchodilation that can last up to 12 hours after each inhalation.

The prescribed dose of Inaspir Accuhaler is determined by the treating physician based on the individual’s disease severity, age and response to therapy. The prescriber decides the number of inhalations per day and the timing of each dose.

The safety of Salmeterol in pregnancy and lactation has not been definitively established. It should be used only if the potential benefit justifies any possible risk to the fetus or infant, and the decision should be made in consultation with a healthcare professional.

To place an order, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Inaspir Accuhaler delivers Salmeterol via a dry‑powder inhaler, offering a consistent dose of 50 µg per inhalation and a duration of action of up to 12 hours. Compared with other LABAs such as formoterol, Salmeterol has a slower onset but a similar duration, and the Accuhaler device may be preferred by patients who find dry‑powder inhalers easier to use.

The inhaler should be stored at temperatures below 25 °C, in its original packaging, protected from moisture and direct sunlight. Keep the device out of reach of children and avoid exposing it to extreme heat or humidity.

The patient inhales a single dose by placing the Accuhaler in the mouth, sealing the lips around the mouthpiece, and breathing in forcefully and deeply. After inhalation, the patient should hold their breath for about 10 seconds to allow optimal drug deposition, then exhale slowly.

Serious adverse events include paradoxical bronchospasm, severe allergic reactions such as anaphylaxis, cardiac arrhythmias, and significant drops in blood potassium (hypokalemia). Patients should seek immediate medical attention if they experience sudden worsening of breathing, chest pain, palpitations or signs of an allergic reaction.

Inaspir Accuhaler is contraindicated in patients with a known hypersensitivity to Salmeterol or any component of the inhaler, and it should be avoided in individuals who require a rapid‑acting bronchodilator for acute symptom relief. Caution is also advised for patients with severe cardiovascular disorders.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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