Product image of Inaspir (Salmeterol) supplied by GNH India

Inaspir

Active Ingredient:
Salmeterol
Origin:
EU

Inaspir (Salmeterol)

Salmeterol, the active ingredient in Inaspir, is a long‑acting β2‑adrenergic agonist (LABA) presented as an inhalation for inhalation use. It provides prolonged bronchodilation for the treatment of asthma and chronic obstructive pulmonary disease (COPD) in adult patients. It is indicated for maintenance therapy and is administered via a metered‑dose inhaler designed for precise dose delivery.

GNH India supplies Inaspir as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, ensuring consistent quality and regulatory compliance across all markets.

Manufacturer / TM Owner

Glaxosmithkline, S.A.

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Indications & Clinical Uses

  • Salmeterol is a long‑acting β2‑adrenergic agonist used in the management of obstructive airway diseases.
  • Asthma: improves bronchodilation and reduces symptoms in patients with persistent asthma when used as maintenance therapy.
  • COPD: provides sustained bronchodilation to improve airflow and decrease exacerbation frequency in COPD patients.
  • Maintenance therapy: used in combination with inhaled corticosteroids to achieve better asthma control and reduce the risk of severe attacks.
  • Exercise‑induced bronchoconstriction: helps prevent bronchospasm triggered by physical activity in asthma patients.

How It Works

  • Salmeterol selectively binds to β2‑adrenergic receptors on airway smooth‑muscle cells, activating adenylate cyclase and increasing intracellular cyclic AMP. The rise in cAMP leads to relaxation of bronchial smooth muscle, producing a prolonged bronchodilatory effect that lasts up to 12 hours after inhalation. This prolonged action allows twice‑daily dosing and contributes to improved lung function and symptom control when combined with anti‑inflammatory agents.

Side Effects

Common and serious adverse reactions have been reported with salmeterol inhalation.

Common Side Effects

  • Throat irritation
  • Cough
  • Headache
  • Tremor

Serious or Rare Side Effects

  • Paradoxical bronchospasm
  • Tachyarrhythmia
  • Severe allergic reaction (anaphylaxis)

Precautions & Warnings

When prescribing Inaspir, clinicians should consider several safety measures.

  • Cardiovascular assessment: evaluate patients with known heart disease before initiating therapy.
  • Monitor asthma control: watch for worsening symptoms or reduced response.
  • Use with inhaled corticosteroid: combine to lower risk of asthma‑related death.
  • Hypersensitivity: discontinue if patient experiences allergic reactions.
  • Pregnancy and lactation: assess risk–benefit; limited data available.
  • Store at room temperature: keep in original container, protect from moisture and heat.

Avoid Interactions

Salmeterol may interact with other medicines, requiring caution.

Major Interactions (Avoid)

  • Beta‑blockers: may diminish bronchodilator effect and precipitate bronchospasm.
  • Monoamine oxidase inhibitors: risk of enhanced cardiovascular effects.
  • Diuretics: can increase risk of hypokalemia when combined with salmeterol.

Moderate Interactions (Monitor Closely)

  • Inhaled corticosteroids: may increase systemic exposure; monitor for side effects.
  • Theophylline: salmeterol may raise theophylline plasma levels; adjust dose if needed.
  • CYP3A4 inhibitors: may elevate salmeterol concentrations; observe for increased adverse effects.

Frequently Asked Questions

Inaspir contains salmeterol, a long‑acting β2‑adrenergic agonist indicated for maintenance treatment of asthma and chronic obstructive pulmonary disease (COPD). It provides prolonged bronchodilation to improve breathing and reduce exacerbations. The product is prescribed for adult patients as part of a long‑term management plan, often together with an inhaled corticosteroid.

Salmeterol selectively stimulates β2‑adrenergic receptors on airway smooth‑muscle cells, activating adenylate cyclase and raising cyclic AMP levels. The increased cAMP causes relaxation of bronchial smooth muscle, resulting in sustained bronchodilation that can last up to 12 hours after a single inhalation.

The prescribed dose of Inaspir is determined by the treating physician based on the individual’s disease severity, age, and response to therapy. Dosing instructions are provided on the product label and must be followed exactly as directed by a qualified healthcare professional.

Safety data for salmeterol during pregnancy and lactation are limited. The medication should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant, and the decision should be made in consultation with a healthcare provider.

To request Inaspir, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Inaspir (salmeterol) is a long‑acting β2‑agonist, offering bronchodilation for up to 12 hours, whereas short‑acting β2‑agonists such as albuterol provide relief for 4–6 hours. Compared with other LABAs like formoterol, salmeterol has a slower onset but a similar duration, and it is typically used in combination with inhaled corticosteroids for optimal asthma control.

Inaspir should be stored at room temperature, below 25 °C, in its original packaging to protect it from moisture and direct sunlight. Keep the inhaler cap closed when not in use and avoid exposing the device to extreme temperatures or humidity, which could affect dose accuracy.

Inaspir is delivered via a metered‑dose inhaler. The patient should inhale slowly and deeply, actuate the inhaler at the start of inhalation, and hold the breath for several seconds before exhaling. The device should be primed according to the manufacturer’s instructions before the first use and after a period of non‑use.

The most serious risks include paradoxical bronchospasm, which can worsen breathing, and cardiovascular events such as tachyarrhythmias or chest pain. Rarely, severe allergic reactions like anaphylaxis may occur. Patients should seek immediate medical attention if they experience sudden worsening of symptoms, chest discomfort, rapid heartbeat, or signs of an allergic reaction.

Inaspir is contraindicated in patients with known hypersensitivity to salmeterol or any component of the inhaler. It should also be avoided in individuals who have experienced a severe asthma attack requiring intubation or in those using non‑selective β‑blockers, as these conditions may increase the risk of adverse reactions. Consultation with a healthcare professional is essential before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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