Product image of Inbrija (Levodopa) supplied by GNH India

Inbrija

Active Ingredient:
Levodopa
Origin:
EU

Inbrija (Levodopa)

Levodopa, the active ingredient in Inbrija, is a dopamine precursor presented as an inhalation powder for inhalation use. It is used to treat OFF episodes in Parkinson's disease as an adjunct therapy for patients already receiving oral levodopa.\n\nGNH India supplies Inbrija as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Acorda Therapeutics Ireland Limited

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

  • Inbrija is indicated for adjunct therapy in Parkinson's disease, targeting motor fluctuations associated with dopaminergic deficiency.\n\n- OFF episodes in Parkinson's disease: rapid relief of motor symptoms during periods of reduced oral levodopa effect.\n- Adjunct to oral levodopa therapy: enhances overall dopaminergic coverage and reduces OFF time.\n- Motor fluctuations in Parkinson's disease: decreases the duration and severity of OFF periods when combined with standard treatment.

How It Works

  • Levodopa is absorbed through the pulmonary epithelium after inhalation and enters the systemic circulation, where it crosses the blood‑brain barrier and is decarboxylated to dopamine. The increased central dopamine compensates for the deficient endogenous supply in Parkinson's disease, thereby improving motor control and reducing OFF episodes.

Side Effects

  • Inbrija may cause a range of adverse reactions.\n\nCommon Side Effects:\n- Cough or throat irritation\n- Nausea\n- Dizziness\n- Headache\n- Dry mouth\n- Upper respiratory discomfort\n\nSerious or Rare Side Effects:\n- Dyskinesia (involuntary movements)\n- Orthostatic hypotension\n- Hallucinations or psychosis\n- Pulmonary edema\n- Severe allergic reactions (anaphylaxis)\n- Respiratory compromise in patients with underlying lung disease

Precautions & Warnings

  • Prior to initiating Inbrija, clinicians should consider several safety measures.\n\n- Cardiovascular assessment: monitor for orthostatic hypotension and blood pressure changes.\n- Concomitant MAO‑B inhibitors: avoid use together due to risk of hypertensive reactions.\n- Respiratory conditions: use with caution in patients with asthma, COPD, or other chronic lung diseases.\n- Dyskinesia monitoring: adjust oral levodopa dose if excessive involuntary movements develop.\n- Store at ambient temperature: keep in the original container, protect from moisture and heat.

Avoid Interactions

  • Inbrija can interact with several medication classes.\n\nMajor Interactions (Avoid):\n- Non‑selective MAO inhibitors: risk of hypertensive crisis.\n- MAO‑B inhibitors (e.g., selegiline, rasagiline): may increase levodopa plasma levels.\n- Pyridoxine (vitamin B6) at high doses: can reduce levodopa efficacy.\n\nModerate Interactions (Monitor Closely):\n- Anticholinergic agents: may enhance anticholinergic side effects.\n- Dopamine antagonists (e.g., typical antipsychotics): may diminish therapeutic response.

Frequently Asked Questions

Inbrija is prescribed as an adjunct therapy for patients with Parkinson's disease who experience OFF episodes. It provides rapid delivery of levodopa via inhalation to quickly restore motor function when oral levodopa levels are insufficient.

Levodopa in Inbrija is absorbed through the lungs, enters the bloodstream, and crosses the blood‑brain barrier where it is converted to dopamine. This replenishes depleted central dopamine, improving the motor symptoms characteristic of Parkinson's disease.

The prescribed dose of Inbrija is determined by the treating physician based on the individual’s clinical condition and existing oral levodopa regimen. The prescriber decides the number of inhalations and frequency appropriate for each patient.

Safety data for Inbrija in pregnancy and lactation are limited. It should only be used if the potential benefit justifies any possible risk to the fetus or infant, and the decision must be made by a qualified healthcare professional.

To request Inbrija, submit an enquiry on the product page at gnhindia.com specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Inbrija delivers levodopa directly to the bloodstream via inhalation, producing a faster onset of action compared with oral tablets, which must pass through the gastrointestinal tract. This rapid delivery can more effectively abort OFF episodes, while oral tablets remain the primary long‑term maintenance therapy.

Inbrija should be stored at ambient temperature, below 25 °C, in its original packaging. Keep the product away from moisture and direct sunlight, and ensure the inhalation device is clean and dry before each use.

Inbrija is a dry‑powder inhalation product. The patient uses a single‑use inhaler device, loading a dose of powder and inhaling deeply as instructed. The device delivers the medication to the lungs, where it is absorbed into the systemic circulation.

Serious risks include dyskinesia (involuntary movements), orthostatic hypotension, hallucinations or psychosis, and rare pulmonary complications such as edema. Patients should be monitored for these events, especially when initiating therapy or adjusting concurrent Parkinson's medications.

Inbrija is contraindicated in patients with known hypersensitivity to levodopa or any excipients, those taking non‑selective MAO inhibitors, and individuals with severe respiratory disorders that could be worsened by inhaled powder. Caution is also advised for patients with uncontrolled cardiovascular disease.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.