Product image of Inbrija (Levodopa) supplied by GNH India

Inbrija

Active Ingredient:
Levodopa
Origin:
EU

Inbrija (Levodopa)

Levodopa, the active ingredient in Inbrija, is a dopamine precursor presented as an 84 mg inhalation powder for inhalation use. It is used to treat OFF episodes in Parkinson's disease as an adjunctive therapy, providing rapid onset of symptom relief when oral medications are insufficient.

GNH India supplies Inbrija as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with full EU market authorization and adherence to stringent quality standards. The company ensures cold‑chain logistics where required and offers comprehensive regulatory documentation to support importation.

Manufacturer / TM Owner

Acorda Therapeutics Ireland Limited

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Indications & Clinical Uses

Inbrija, a levodopa‑based inhalation therapy, is used in the management of Parkinson's disease motor fluctuations.

  • Parkinson's disease: improves motor function during OFF episodes
  • OFF episodes: provides rapid symptom relief
  • Motor fluctuations: shortens duration of OFF periods

How It Works

  • Levodopa is absorbed through the pulmonary epithelium after inhalation, entering the bloodstream and crossing the blood‑brain barrier. Within the central nervous system it is decarboxylated by aromatic L‑amino‑acid decarboxylase to dopamine, directly replenishing depleted dopaminergic neurotransmission and thereby improving motor control in Parkinson's disease. The rapid pulmonary delivery bypasses gastrointestinal absorption variability and first‑pass metabolism, allowing a quicker rise in brain dopamine levels compared with oral levodopa formulations.

Side Effects

Inbrija may be associated with several adverse reactions, which are categorized by frequency.

Common Side Effects

  • Cough: mild irritation of the throat after inhalation
  • Throat irritation: transient soreness or dryness
  • Nausea: occasional upset stomach
  • Dizziness: light‑headed sensation, especially on standing

Serious or Rare Side Effects

  • Dyskinesia: involuntary movements that may become pronounced
  • Orthostatic hypotension: sudden drop in blood pressure upon standing
  • Hallucinations or psychosis: rare neuropsychiatric events

Precautions & Warnings

Before initiating Inbrija, clinicians should consider several safety measures.

  • Assess cardiovascular status: monitor blood pressure and heart rate
  • Evaluate respiratory function: avoid in patients with severe asthma or COPD
  • Review hepatic function: dose adjustment may be needed in liver impairment
  • Check for dyskinesia history: risk may increase with levodopa exposure
  • Instruct on proper inhalation technique: ensures optimal drug delivery
  • Store at room temperature: keep in original container, protect from moisture

Avoid Interactions

Inbrija can interact with other medicines; interactions are grouped by clinical significance.

Major Interactions (Avoid)

  • Non‑selective MAO inhibitors: may cause hypertensive crisis
  • Antipsychotics (dopamine antagonists): can reduce therapeutic effect
  • COMT inhibitors: increase levodopa plasma levels, raising risk of side effects

Moderate Interactions (Monitor Closely)

  • MAO‑B inhibitors: may enhance dopaminergic activity
  • Antihypertensive agents: risk of additive orthostatic hypotension
  • Iron or calcium supplements: may reduce levodopa absorption if taken simultaneously
  • SSRIs or other serotonergic drugs: monitor for serotonin syndrome signs

Frequently Asked Questions

Inbrija is prescribed as an adjunctive treatment for patients with Parkinson's disease who experience OFF episodes, providing rapid relief of motor symptoms when oral levodopa therapy is insufficient.

Levodopa in Inbrija is inhaled, absorbed through the lungs, and converted to dopamine in the brain. This replenishes depleted dopamine stores, improving motor control and reducing the severity of OFF periods.

The prescribed dose of Inbrija is determined by the treating physician based on the individual’s clinical condition and response. The prescriber decides the number of inhalations and timing.

The safety of Inbrija in pregnancy or while breastfeeding has not been established. It should only be used if the potential benefit justifies the potential risk to the fetus or infant.

To order Inbrija, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and import documentation.

Inbrija delivers levodopa via inhalation, bypassing the gastrointestinal tract and first‑pass metabolism. This results in a faster rise in brain dopamine levels and more rapid symptom relief compared with oral tablets, which may have delayed onset due to absorption variability.

Inbrija should be stored at room temperature, below 25 °C, in its original packaging. Keep the device protected from moisture and direct sunlight to maintain powder stability.

Inbrija is administered using a single‑use inhaler device. The patient inhales the powder deeply through the mouthpiece as instructed, typically during an OFF episode, following the training provided by a healthcare professional.

Serious risks include dyskinesia, orthostatic hypotension, and rare neuropsychiatric events such as hallucinations. Patients should be monitored for these effects, especially when initiating therapy or adjusting doses.

Inbrija is contraindicated in patients with known hypersensitivity to levodopa or any component of the inhalation powder, and it should be avoided in individuals with severe respiratory disorders that could impair inhalation.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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