Product image of Indamid Sr (Indapamide) supplied by GNH India

Indamid Sr

Active Ingredient:
Indapamide
Origin:
EU

Indamid Sr (Indapamide)

Indapamide, the active ingredient in Indamid Sr, is a thiazide‑like diuretic presented as an oral dosage form for systemic use. It is employed to lower elevated blood pressure and to reduce fluid accumulation in conditions such as heart failure‑related edema and renal disease‑associated edema.

GNH India supplies Indamid Sr as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, providing reliable sourcing, regulatory support and consistent product quality across multiple markets, and adhering to stringent quality standards.

Manufacturer / TM Owner

Belupo D.D.

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Indications & Clinical Uses

  • Indapamide is used to manage conditions related to fluid overload and elevated blood pressure.
  • Hypertension: helps lower systemic arterial pressure and reduce cardiovascular risk.
  • Edema associated with heart failure: promotes diuresis to decrease fluid accumulation and relieve symptoms.
  • Edema due to renal disease: facilitates removal of excess fluid in patients with renal impairment.

How It Works

  • Indapamide blocks the Na⁺/Cl⁻ cotransporter in the distal convoluted tubule, decreasing sodium and chloride reabsorption. This results in increased urinary excretion of water and electrolytes, lowering plasma volume and peripheral vascular resistance, which together produce antihypertensive and diuretic effects.

Side Effects

Indapamide may be associated with a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Dizziness or light‑headedness
  • Headache
  • Electrolyte disturbances (e.g., low potassium or sodium)
  • Increased uric acid levels
  • Elevated blood glucose
  • Photosensitivity or mild skin rash

Serious or Rare Side Effects

  • Severe electrolyte imbalance leading to cardiac arrhythmia
  • Acute renal failure or significant rise in creatinine
  • Severe hypersensitivity reactions such as angioedema or anaphylaxis
  • Pancreatitis
  • Marked hypotension causing fainting or shock

Precautions & Warnings

  • When prescribing indapamide, clinicians should consider several safety measures.
  • Monitor electrolytes: check serum potassium, sodium and uric acid regularly.
  • Assess renal function: evaluate creatinine and eGFR before and during therapy.
  • Avoid abrupt discontinuation: taper dose to prevent rebound hypertension.
  • Caution in diabetes: monitor blood glucose as thiazide may raise glucose levels.
  • Pregnancy and lactation: use only if clearly needed, as safety data are limited.
  • Store at ambient temperature: keep below 25 °C, protect from moisture and light in original container.

Avoid Interactions

Indapamide can interact with several medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Lithium: increased risk of lithium toxicity.
  • Ciclosporin: may enhance nephrotoxic effects.
  • Potassium‑sparing diuretics: risk of hyperkalemia.
  • ACE inhibitors or ARBs: may cause excessive potassium rise.
  • Other antihypertensives: additive blood‑pressure lowering effect.

Moderate Interactions (Monitor Closely)

  • NSAIDs: may reduce diuretic efficacy and affect renal function.
  • Digitalis glycosides: increased risk of arrhythmia due to electrolyte shifts.
  • Antidiabetic agents: potential for enhanced hypoglycaemia.
  • Corticosteroids: may exacerbate electrolyte loss.
  • Antihyperuricemic drugs: may require dose adjustment for uric acid control.

Frequently Asked Questions

Indamid Sr contains indapamide, a thiazide‑like diuretic indicated for management of hypertension and for reduction of fluid overload in edema associated with heart failure or renal disease. It is prescribed by healthcare professionals to lower blood pressure and to promote diuresis in these conditions.

Indapamide inhibits the Na⁺/Cl⁻ cotransporter in the distal convoluted tubule of the kidney, reducing sodium and chloride reabsorption. This leads to increased urinary excretion of water and electrolytes, decreasing plasma volume and peripheral vascular resistance, which together lower blood pressure and alleviate edema.

The dosage of indapamide is individualized by the prescribing clinician based on the patient’s condition, renal function, and response to therapy. Typical adult regimens range from 1.5 mg to 2.5 mg once daily, but exact dosing must be determined by a qualified healthcare provider.

Safety data for indapamide in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the potential risk to the fetus or infant, and the decision should be made by the prescriber in consultation with the patient. Breastfeeding mothers should discuss alternatives with their doctor.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity of Indamid Sr. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Indapamide is a thiazide‑like diuretic that offers a longer duration of action and a lower incidence of metabolic side effects such as hypokalemia compared with traditional thiazide diuretics like hydrochlorothiazide. It is often chosen when clinicians need effective blood‑pressure control with a favorable electrolyte profile.

Indamid Sr should be stored at ambient temperature, preferably below 25 °C, in its original packaging. Protect the product from moisture, excessive heat and direct sunlight to maintain its stability and potency throughout its shelf life.

Indamid Sr is taken orally, usually once daily in the morning, with or without food as directed by the prescriber. Swallow the tablet whole with a full glass of water and follow any specific instructions regarding timing relative to other medications.

Serious adverse events, although uncommon, include severe electrolyte disturbances such as hyponatremia or hypokalemia, acute renal failure, and hypersensitivity reactions that may present as rash, angioedema or anaphylaxis. Patients should seek immediate medical attention if they experience symptoms like muscle weakness, irregular heartbeat, severe dizziness, or swelling of the face and throat.

Indapamide is contraindicated in patients with known hypersensitivity to indapamide or other sulfonamide‑derived drugs, and should be used with caution in individuals with severe renal impairment, uncontrolled diabetes, gout, or those taking lithium. Pregnant or breastfeeding women should only use it when clearly indicated by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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