Product image of Indapamid Krka (Indapamide) supplied by GNH India

Indapamid Krka

Active Ingredient:
Indapamide
Origin:
EU

Indapamid Krka (Indapamide)

Indapamide, the active ingredient in Indapamid Krka, is a thiazide‑like diuretic presented as an oral dosage form for oral use. It is used to treat hypertension and to reduce edema associated with heart failure in adult patients.\n\nGNH India supplies Indapamid Krka as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Krka, D.D., Novo Mesto

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Indications & Clinical Uses

  • Indapamide acts on the renal distal convoluted tubule and vascular resistance pathways to manage fluid balance and blood pressure.\n\nHypertension: lowers systolic and diastolic blood pressure in patients with primary hypertension.\nEdema associated with heart failure: promotes diuresis to reduce fluid overload and peripheral swelling.\nCongestive heart failure: assists in controlling volume status and improving symptom relief.

How It Works

  • Indapamide inhibits sodium‑chloride reabsorption in the distal convoluted tubule of the nephron, leading to increased urinary excretion of sodium, chloride, and water. The resulting reduction in plasma volume decreases cardiac preload, while direct vasodilatory effects lower peripheral vascular resistance, together contributing to blood‑pressure reduction and edema control.

Side Effects

  • Indapamide may cause a range of adverse reactions, from mild to severe.\n\nCommon Side Effects:\n- Dizziness or light‑headedness\n- Headache\n- Increased frequency of urination\n- Electrolyte disturbances, especially low potassium\n- Muscle cramps or weakness\n- Fatigue\n\nSerious or Rare Side Effects:\n- Severe dehydration or electrolyte imbalance\n- Hyponatremia or hyperuricemia leading to gout attacks\n- Allergic reactions such as rash, angioedema, or anaphylaxis\n- Pancreatitis\n- Blood dyscrasias including leukopenia or thrombocytopenia

Precautions & Warnings

  • Before initiating therapy, clinicians should evaluate patient‑specific factors and monitor for potential complications.\n\nMonitor electrolytes: check serum potassium and sodium regularly.\nAssess renal function: evaluate creatinine clearance before and during treatment.\nUse caution in diabetes: may affect glucose control.\nAvoid in severe hepatic impairment: limited data on safety.\nEvaluate gout risk: hyperuricemia may precipitate attacks.\nStore at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

  • Indapamide can interact with several medicines, requiring attention to avoid reduced efficacy or increased toxicity.\n\nMajor Interactions (Avoid):\n- Lithium: risk of lithium toxicity due to reduced clearance.\n- Ciclosporin: increased nephrotoxic potential.\n- Antidiabetic agents: may enhance hypoglycaemic effect.\n\nModerate Interactions (Monitor Closely):\n- ACE inhibitors or ARBs: may potentiate hypotensive effect.\n- Non‑steroidal anti‑inflammatory drugs (NSAIDs): may diminish diuretic response and affect renal function.\n- Other antihypertensives: additive blood‑pressure lowering may require dose adjustment.

Frequently Asked Questions

Indapamid Krka contains indapamide, which is prescribed to manage high blood pressure (hypertension) and to reduce fluid accumulation (edema) in patients with heart failure.

Indapamide blocks sodium‑chloride reabsorption in the kidney’s distal convoluted tubule, increasing urine output and lowering blood volume. It also relaxes blood vessels, helping to lower peripheral resistance and blood pressure.

The appropriate dose is determined by the prescribing clinician based on the patient’s medical condition, response to therapy, and renal function. Dosage adjustments are made individually.

Safety in pregnancy and lactation has not been fully established. The drug should only be used if the potential benefit justifies any possible risk to the fetus or infant, and under medical supervision.

Submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and import documentation.

Indapamide is a thiazide‑like diuretic offering a longer duration of action and a lower incidence of metabolic side effects compared with classic thiazides such as hydrochlorothiazide, making it a preferred option for some patients.

Store at room temperature, below 25 °C, in the original packaging. Protect the product from moisture, heat and direct sunlight to maintain stability.

Indapamid Krka is taken orally, usually once daily with or without food, as directed by the prescribing healthcare professional.

Serious risks include severe dehydration, electrolyte disturbances (especially low potassium), hyponatremia, allergic reactions such as anaphylaxis, and rare blood disorders. Patients should be monitored regularly for these events.

Patients with known hypersensitivity to indapamide or other sulfonamide diuretics, those with severe renal or hepatic impairment, and individuals with uncontrolled gout should avoid using this medication.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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