Product image of Indapamida Ciclum (Indapamide) supplied by GNH India

Indapamida Ciclum

Active Ingredient:
Indapamide
Origin:
EU

Indapamida Ciclum (Indapamide)

Indapamide, the active ingredient in Indapamida Ciclum, is a thiazide‑like diuretic presented as an oral tablet for systemic use. It is employed to lower elevated blood pressure in adults and to reduce fluid retention in patients with edema related to congestive heart failure, and improve cardiovascular outcomes.

GNH India supplies Indapamida Ciclum as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide, with a focus on quality assurance and regulatory compliance.

Manufacturer / TM Owner

Ciclum Farma Unipessoal Lda.

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Indications & Clinical Uses

  • Indapamide is indicated for conditions within the cardiovascular and renal fluid‑balance pathways.
  • Hypertension: lowers systolic and diastolic blood pressure, helping to prevent cardiovascular complications.
  • Edema associated with congestive heart failure: increases urinary excretion of sodium and water, reducing peripheral swelling and improving symptoms.
  • Hypertension combined with other antihypertensive agents: can be added to existing therapy to achieve better blood pressure control when monotherapy is insufficient.

How It Works

  • Indapamide acts on the distal convoluted tubule of the nephron by inhibiting the Na⁺/Cl⁻ cotransporter. This blockade reduces sodium and chloride reabsorption, leading to increased diuresis. The resulting decrease in extracellular fluid volume lowers cardiac preload and peripheral vascular resistance, contributing to its antihypertensive effect. Additionally, indapamide has a mild vasodilatory action that further reduces blood pressure.

Side Effects

Indapamide may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Dizziness
  • Increased urination
  • Electrolyte disturbances (especially low potassium)
  • Headache

Serious or Rare Side Effects

  • Severe dehydration
  • Hyponatremia
  • Allergic reactions such as rash or anaphylaxis

Precautions & Warnings

When prescribing indapamide, clinicians should consider several precautionary measures to ensure safe use.

  • Monitor electrolytes: perform regular blood tests for sodium, potassium and chloride levels.
  • Assess renal function: check creatinine and eGFR before initiating therapy and periodically thereafter.
  • Use caution in patients with gout: the drug may increase serum uric acid.
  • Avoid in severe hepatic impairment: limited safety data are available.
  • Adjust dose in elderly patients: increased sensitivity to diuretic effects may occur.
  • Store at room temperature: keep in the original pack, protect from moisture.

Avoid Interactions

Indapamide can interact with various medicines; some combinations should be avoided, while others require careful monitoring.

Major Interactions (Avoid)

  • Lithium: may increase lithium toxicity.
  • NSAIDs: can blunt the diuretic effect and reduce blood pressure control.
  • Cyclosporine: may enhance nephrotoxic risk.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: risk of excessive potassium changes.
  • Beta‑blockers: additive blood pressure‑lowering effect.
  • Antidiabetic agents: may potentiate hypoglycemia.

Frequently Asked Questions

Indapamida Ciclum contains indapamide, a thiazide‑like diuretic that is prescribed to lower high blood pressure and to reduce fluid accumulation in patients with edema caused by congestive heart failure. It helps control cardiovascular risk factors and improve symptom relief in these conditions.

Indapamide inhibits the sodium‑chloride cotransporter in the distal convoluted tubule of the kidney. By blocking this transporter, it reduces reabsorption of sodium and chloride, leading to increased urine output. The resulting loss of fluid lowers blood volume, decreases peripheral vascular resistance, and produces an antihypertensive effect.

The exact dose of Indapamida Ciclum is determined by the prescribing healthcare professional based on the individual’s medical condition, response to therapy, and other factors. Physicians typically start with a standard adult dose and may adjust it as needed, but specific dosing regimens should not be inferred without a prescription.

Safety data for indapamide in pregnancy and lactation are limited. The drug should only be used if the potential benefit to the mother outweighs any possible risk to the fetus or infant. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss alternatives with their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity of Indapamida Ciclum. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Indapamide and hydrochlorothiazide belong to the same thiazide‑like class but differ in potency and duration of action. Indapamide often provides a longer‑lasting antihypertensive effect with a lower incidence of certain metabolic side effects, while hydrochlorothiazide is frequently used for milder hypertension and as a first‑line agent. Choice depends on clinical response and patient tolerance.

Indapamida Ciclum should be stored at room temperature, below 25 °C. Keep the tablets in the original packaging to protect them from moisture and light. Do not store in bathrooms or near heat sources, and keep out of reach of children.

The medication is taken orally, usually with a full glass of water. It can be taken with or without food, but consistent timing each day helps maintain stable blood levels. Patients should follow the dosing schedule prescribed by their clinician and avoid crushing or chewing the tablets unless instructed otherwise.

Serious risks include severe dehydration, marked electrolyte disturbances such as hyponatremia or hypokalemia, and rare allergic reactions that may present as rash, angioedema or anaphylaxis. Prompt medical attention is required if symptoms like extreme weakness, rapid heartbeat, confusion, or swelling of the face and throat occur.

Indapamida Ciclum is contraindicated in patients with anuria (no urine output), severe renal impairment, known hypersensitivity to indapamide or other sulfonamide drugs, and in individuals with severe hepatic disease where safety has not been established. Clinicians should review the patient’s medical history before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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