Product image of Indapamida Zentiva (Indapamide) supplied by GNH India

Indapamida Zentiva

Active Ingredient:
Indapamide
Origin:
EU

Indapamida Zentiva (Indapamide)

Indapamide, the active ingredient in Indapamida Zentiva, is a thiazide-like diuretic presented as an oral tablet for oral use. It is employed to manage high blood pressure and reduce fluid retention in conditions such as heart failure and renal disease.
GNH India supplies Indapamida Zentiva as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Zentiva Portugal, Lda

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Indications & Clinical Uses

  • Indapamide acts on the renal distal convoluted tubule to promote diuresis, making it useful in several cardiovascular and renal conditions.
  • Hypertension: lowers systolic and diastolic blood pressure to reduce cardiovascular risk.
  • Edema associated with heart failure: decreases fluid overload, improving symptoms and exercise tolerance.
  • Edema associated with renal disease: enhances urinary excretion of excess fluid, alleviating swelling.

How It Works

  • Indapamide inhibits the Na⁺/Cl⁻ cotransporter in the distal convoluted tubule, reducing sodium and chloride reabsorption. This leads to increased urinary excretion of water and electrolytes, decreasing plasma volume and peripheral vascular resistance, which together lower blood pressure and relieve fluid accumulation.

Side Effects

Indapamide may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Dizziness or light‑headedness, especially after the first doses.
  • Increased frequency of urination or nocturia.
  • Electrolyte disturbances such as low potassium or sodium.
  • Headache and mild nausea.
  • Fatigue or general weakness.

Serious or Rare Side Effects

  • Severe dehydration or electrolyte imbalance requiring medical attention.
  • Acute gout attacks triggered by uric acid changes.
  • Pancreatitis or severe abdominal pain.
  • Allergic reactions including rash, angioedema, or anaphylaxis.
  • Blood dyscrasias such as agranulocytosis or thrombocytopenia.

Precautions & Warnings

Before initiating therapy, consider the following safety measures.

  • Monitor electrolytes: check serum potassium, sodium, and magnesium regularly.
  • Assess renal function: evaluate creatinine clearance and adjust use if impaired.
  • Use caution in patients with gout: indapamide may raise uric acid levels.
  • Adjust dose in the elderly: start low and monitor for orthostatic hypotension.
  • Avoid in severe hepatic impairment: limited data suggest increased risk.
  • Store at below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Indapamide can interact with several medicines, altering efficacy or safety.

Major Interactions (Avoid)

  • Lithium: increased lithium levels may cause toxicity.
  • NSAIDs: may reduce diuretic effect and impair renal function.
  • ACE inhibitors or ARBs: combined use can lead to excessive potassium loss.

Moderate Interactions (Monitor Closely)

  • Digoxin: enhanced risk of digoxin toxicity due to electrolyte shifts.
  • Warfarin: potential alteration of INR, requiring closer monitoring.
  • Corticosteroids: may counteract diuretic effect and increase fluid retention.
  • Other antihypertensives: additive blood pressure lowering, watch for hypotension.

Frequently Asked Questions

Indapamida Zentiva contains indapamide, a thiazide‑like diuretic prescribed to lower high blood pressure and to reduce fluid buildup in patients with heart failure‑related or renal‑related edema. It helps control hypertension and alleviate swelling by promoting the excretion of excess water and salts.

Indapamide blocks the sodium‑chloride cotransporter in the distal convoluted tubule of the kidney. This inhibition reduces reabsorption of sodium and chloride, leading to increased urine output, lower plasma volume, and decreased peripheral vascular resistance, which together lower blood pressure and reduce edema.

The specific dose of Indapamida Zentiva is determined by the prescribing clinician based on the patient’s medical condition, response to therapy, and renal function. Dosage adjustments are individualized, and patients should follow the prescriber’s instructions without self‑adjusting the amount.

Safety data for indapamide in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the possible risk to the fetus or infant. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss alternatives with their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Indapamide belongs to the thiazide‑like class, offering potent antihypertensive effects with a lower incidence of metabolic disturbances compared with classic thiazides. Compared with loop diuretics, it is less powerful for rapid fluid removal but is preferred for long‑term blood pressure control and mild to moderate edema.

Indapamida Zentiva should be stored at temperatures below 25 °C, in its original packaging, and protected from moisture and direct sunlight. Keeping the tablets in a dry, cool environment helps maintain their stability and potency throughout the shelf life.

Indapamida Zentiva is taken orally, usually with a glass of water. It can be taken with or without food, but patients should follow the prescriber’s guidance on timing, especially if other medications are involved, to ensure optimal absorption and effect.

Serious risks include severe electrolyte imbalances (especially low potassium or sodium), dehydration, acute gout attacks, and rare blood disorders such as agranulocytosis. Patients should be monitored for signs of these conditions and seek immediate medical attention if symptoms like muscle weakness, severe abdominal pain, or rash develop.

Indapamida Zentiva is contraindicated in patients with known hypersensitivity to indapamide or other sulfonamide drugs, severe renal impairment, and in those with uncontrolled electrolyte disturbances. Caution is also advised for individuals with severe liver disease, gout, or those taking interacting medications such as lithium.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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