Product image of Indapamide Arrow (Indapamide) supplied by GNH India

Indapamide Arrow

Active Ingredient:
Indapamide
Origin:
EU

Indapamide Arrow (Indapamide)

Indapamide, the active ingredient in Indapamide Arrow, is a thiazide‑like diuretic presented as an oral tablet for systemic use. It is employed to lower elevated blood pressure and to reduce fluid accumulation in patients with congestive heart failure, acting by increasing urine output and decreasing peripheral vascular resistance. The medication is manufactured under EU Good Manufacturing Practice and conforms to European pharmacopoeial specifications.

GNH India supplies Indapamide Arrow as a licensed, GDP‑compliant international pharmaceutical product to hospitals, pharmacies and clinics worldwide across global markets.

Manufacturer / TM Owner

Les Laboratoires Servier (Suresnes)

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Indications & Clinical Uses

  • Indapamide Arrow is used in the management of cardiovascular conditions that involve high blood pressure or fluid overload.
  • Hypertension: reduces systolic and diastolic blood pressure, helping to achieve target levels.
  • Edema associated with congestive heart failure: promotes diuresis to decrease peripheral swelling and improve symptoms.
  • Chronic heart failure: assists in controlling volume status and may lessen the need for higher‑dose loop diuretics.

How It Works

  • Indapamide acts on the distal convoluted tubule of the nephron by inhibiting the Na⁺/Cl⁻ cotransporter. This blockade reduces sodium and chloride reabsorption, leading to increased excretion of water and electrolytes. The resulting diuresis lowers plasma volume, while a direct vasodilatory effect on peripheral arterioles decreases systemic vascular resistance, contributing to blood‑pressure reduction.

Side Effects

Indapamide may cause a range of adverse reactions, which are classified by frequency and severity.

Common Side Effects

  • Dizziness: sensation of light‑headedness, especially after standing.
  • Increased urination: more frequent or larger volume of urine.
  • Electrolyte imbalance (low potassium): mild hypokalemia causing muscle weakness.
  • Headache: mild to moderate pain in the head region.

Serious or Rare Side Effects

  • Severe dehydration: marked fluid loss leading to hypotension.
  • Hyponatremia or severe electrolyte disturbances: can cause confusion or seizures.
  • Allergic reaction: rash, itching, swelling, or anaphylaxis.

Precautions & Warnings

When prescribing Indapamide, clinicians should consider several precautionary measures to ensure safe use.

  • Monitor electrolytes: check serum potassium and sodium regularly.
  • Assess renal function: evaluate creatinine clearance before initiation and during therapy.
  • Use caution in gout: the drug may increase serum uric acid levels.
  • Adjust dose in hepatic impairment: consider lower starting dose if liver disease is present.
  • Avoid abrupt discontinuation: taper gradually to prevent rebound hypertension.
  • Store at below 25°C: keep in the original packaging, protect from moisture and light.

Avoid Interactions

Indapamide can interact with other medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Lithium: increased lithium levels may cause toxicity.
  • NSAIDs: may reduce diuretic effect and impair renal function.
  • ACE inhibitors or ARBs: combined use can lead to excessive potassium elevation.

Moderate Interactions (Monitor Closely)

  • Digoxin: risk of increased serum digoxin concentration.
  • Antidiabetic agents: hypoglycemia risk may be heightened.
  • Warfarin: potential for altered anticoagulant effect.
  • Corticosteroids: may enhance sodium retention counteracting diuretic action.

Frequently Asked Questions

Indapamide Arrow is prescribed to manage high blood pressure (hypertension) and to treat fluid retention (edema) that occurs with congestive heart failure. By lowering vascular resistance and promoting urine output, it helps achieve target blood‑pressure levels and reduces swelling in the extremities.

Indapamide inhibits the sodium‑chloride cotransporter in the distal convoluted tubule of the kidney. This reduces reabsorption of sodium and chloride, leading to increased excretion of water and electrolytes. The resulting decrease in plasma volume, together with a direct vasodilatory effect on peripheral vessels, lowers systemic blood pressure.

The appropriate dose of Indapamide Arrow is determined by the prescribing clinician based on the individual’s medical condition, response to therapy, and renal function. Physicians typically start with a low dose and adjust as needed, following local prescribing guidelines and patient monitoring.

Safety data for Indapamide in pregnancy and lactation are limited. The drug should only be used when the potential benefit to the mother outweighs any possible risk to the fetus or infant. Healthcare providers should discuss alternative options and closely monitor any pregnant or nursing patient who requires treatment.

To place an order, submit an enquiry on the Indapamide Arrow product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Indapamide belongs to the thiazide‑like diuretic class, offering both diuretic and vasodilatory actions. Compared with classic thiazides such as hydrochlorothiazide, it often provides a longer duration of action and may have a lower risk of metabolic side effects. It is commonly used in combination with other antihypertensives for synergistic blood‑pressure control.

Indapamide Arrow should be stored at temperatures below 25 °C, in its original packaging, protected from moisture and direct light. Keeping the tablets in a dry, tightly closed container helps maintain potency throughout the shelf‑life.

Indapamide Arrow is taken orally, usually with a full glass of water. It can be taken with or without food, but patients should follow the specific instructions provided by their healthcare professional to ensure consistent absorption.

The most serious risks include severe electrolyte disturbances such as hyponatremia or hypokalemia, marked dehydration, and rare allergic reactions that may present as rash, swelling or anaphylaxis. Prompt medical attention is required if any of these severe symptoms develop.

Indapamide Arrow is contraindicated in patients with anuria, severe renal impairment, or known hypersensitivity to indapamide or other thiazide‑like diuretics. Caution is also advised for individuals with severe hepatic disease, gout, or uncontrolled diabetes, and the drug should be avoided unless a physician determines it is appropriate.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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