Product image of Indapamide Aurobindo (Indapamide) supplied by GNH India

Indapamide Aurobindo

Active Ingredient:
Indapamide
Origin:
EU

Indapamide Aurobindo (Indapamide)

Indapamide, the active ingredient in Indapamide Aurobindo, is a thiazide‑like diuretic presented as an oral tablet for oral use. It is indicated for adults and the elderly to lower high blood pressure and to reduce fluid accumulation in patients with heart‑failure‑related or renal‑disease‑related edema, typically given as a once‑daily oral dose.

GNH India supplies Indapamide Aurobindo as a licensed, GDP‑compliant international pharmaceutical supplier, providing reliable bulk shipments to hospitals, pharmacies, and clinics worldwide, and supporting regulatory compliance and quality assurance throughout the supply chain.

Manufacturer / TM Owner

Aurobindo Pharma (Italia) S.R.L.

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Indications & Clinical Uses

  • Indapamide is a thiazide‑like diuretic used to manage conditions involving elevated blood pressure or fluid overload.
  • Hypertension: lowers systolic and diastolic blood pressure, improving cardiovascular risk profile.
  • Edema associated with heart failure: promotes urinary excretion of sodium and water, reducing peripheral swelling.
  • Edema associated with renal disease: facilitates fluid removal in patients with chronic kidney disease‑related swelling.

How It Works

  • Indapamide acts on the distal convoluted tubule of the nephron by inhibiting the Na⁺/Cl⁻ cotransporter. This blockade reduces sodium and chloride reabsorption, leading to increased urinary excretion of sodium, chloride, and water. The resulting decrease in extracellular fluid volume lowers cardiac preload and peripheral vascular resistance, contributing to its antihypertensive effect. Additionally, indapamide possesses mild vasodilatory properties that further aid blood pressure reduction.

Side Effects

Indapamide may cause a range of adverse reactions, which are categorized by frequency and severity.

Common Side Effects

  • Dizziness: sensation of light‑headedness, especially after standing.
  • Increased urination: more frequent need to void.
  • Electrolyte imbalance (low potassium): mild hypokalemia causing muscle weakness.
  • Nausea: upset stomach or feeling sick.

Serious or Rare Side Effects

  • Severe dehydration: excessive fluid loss leading to hypotension.
  • Hyponatremia: low blood sodium that can cause confusion or seizures.
  • Allergic reactions: rash, itching, swelling, or anaphylaxis.
  • Renal impairment: worsening kidney function, indicated by rising creatinine.

Precautions & Warnings

Before initiating indapamide therapy, several safety considerations should be reviewed.

  • Monitor electrolytes: check serum potassium and sodium regularly.
  • Assess renal function: evaluate creatinine clearance prior to treatment.
  • Use caution in diabetes: diuretic‑induced glucose changes may require dose adjustment.
  • Avoid abrupt discontinuation: sudden stop can cause rapid blood‑pressure rebound.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Indapamide can interact with other medicines, altering its efficacy or safety profile.

Major Interactions (Avoid)

  • Lithium: increased lithium levels may cause toxicity.
  • NSAIDs: may reduce diuretic effect and impair kidney function.
  • Cyclosporine: heightened risk of nephrotoxicity.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors: additive blood‑pressure lowering effect, monitor for hypotension.
  • Antidiabetic drugs: enhanced hypoglycaemic effect, adjust glucose monitoring.
  • Beta‑blockers: may potentiate blood‑pressure reduction, observe for bradycardia.

Frequently Asked Questions

Indapamide Aurobindo is a thiazide‑like diuretic indicated for the treatment of hypertension and for reducing fluid overload in patients with edema related to heart failure or chronic kidney disease. It helps lower blood pressure and decrease swelling by promoting the excretion of sodium and water.

Indapamide works by blocking the Na⁺/Cl⁻ cotransporter in the distal convoluted tubule of the kidney. This inhibition reduces reabsorption of sodium and chloride, leading to increased urinary loss of these ions along with water. The resulting reduction in extracellular fluid volume lowers cardiac preload and peripheral vascular resistance, thereby decreasing blood pressure.

The appropriate dose of indapamide is determined by the prescribing healthcare professional based on the individual’s medical condition, response to therapy, and other factors. Dosage information is provided on the prescription label and should be followed exactly as directed by the prescriber.

Safety of indapamide in pregnancy or while breastfeeding has not been definitively established. Healthcare providers will weigh potential benefits against possible risks before prescribing it to pregnant or nursing women. Patients should discuss their specific situation with their doctor to determine the most appropriate therapy.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, confirming trade or institutional credentials before providing pricing, availability, shipping details, and any necessary import documentation.

Indapamide belongs to the thiazide‑like diuretic class and offers a longer duration of action with a lower incidence of metabolic disturbances compared with some traditional thiazides. It is often chosen for patients who need effective blood‑pressure control combined with modest diuretic effect, especially when potassium‑sparing properties are desired.

Indapamide Aurobindo tablets should be stored at room temperature, below 25 °C, in the original packaging. Keep them away from moisture, direct sunlight, and excessive heat to maintain product stability and potency throughout its shelf life.

Indapamide Aurobindo is taken orally, usually as a single tablet once daily. It should be swallowed whole with a glass of water and can be taken with or without food, unless the prescribing physician provides specific instructions regarding timing with meals.

Serious risks include severe dehydration, hyponatremia, significant electrolyte disturbances such as hypokalemia, and rare cases of acute kidney injury. Patients should be monitored for signs of excessive fluid loss, sudden drops in blood pressure, or abnormal laboratory values, and seek medical attention if these occur.

Indapamide is contraindicated in individuals with known hypersensitivity to indapamide or other sulfonamide‑derived drugs. It should also be avoided in patients with severe renal impairment, uncontrolled electrolyte imbalances, or those who are currently taking medications that may cause dangerous interactions, such as lithium, without close medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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