Product image of Indapamide Biogaran (Indapamide Hemihydrate) supplied by GNH India

Indapamide Biogaran

Active Ingredient:
Indapamide Hemihydrate
Origin:
EU

Indapamide Biogaran (Indapamide Hemihydrate)

Indapamide, the active ingredient in Indapamide Biogaran, is a thiazide‑like diuretic presented as an oral tablet for adult use. It is employed to lower elevated blood pressure and to reduce fluid accumulation in patients with heart‑failure‑related edema and improve cardiovascular outcomes under medical supervision.

GNH India supplies Indapamide Biogaran as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. Our global distribution network ensures reliable delivery and regulatory compliance for all qualified healthcare partners. We adhere to stringent quality standards and provide comprehensive documentation to support import and pharmacovigilance requirements. Our team is available to assist with technical queries and post‑market support.

Manufacturer / TM Owner

Biogaran

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Indications & Clinical Uses

  • Indapamide acts on the renal tubular system to manage conditions characterized by elevated blood pressure or fluid overload.
  • Hypertension: reduces systolic and diastolic blood pressure, improving cardiovascular risk profile.
  • Edema associated with heart failure: promotes sodium and water excretion, decreasing peripheral fluid accumulation.
  • Fluid retention in renal or hepatic disease: facilitates diuresis to alleviate swelling.

How It Works

  • Indapamide inhibits the Na⁺/Cl⁻ symporter in the distal convoluted tubule, decreasing sodium and chloride reabsorption. This leads to increased urinary excretion of water and electrolytes, lowering plasma volume and peripheral vascular resistance, which together produce a reduction in blood pressure and promote the removal of excess fluid.

Side Effects

Indapamide may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Dizziness or light‑headedness
  • Headache
  • Increased urinary frequency
  • Electrolyte imbalance, especially low potassium
  • Nausea or abdominal discomfort

Serious or Rare Side Effects

  • Severe dehydration or electrolyte disturbances (e.g., hyponatremia)
  • Acute kidney injury
  • Severe allergic reactions such as Stevens‑Johnson syndrome
  • Gout attacks due to uric acid elevation
  • Blood dyscrasias (e.g., agranulocytosis)

Precautions & Warnings

  • When prescribing Indapamide, clinicians should consider several safety measures to minimize risk.
  • Monitor electrolytes: regular blood tests to detect sodium, potassium and uric acid changes.
  • Assess renal function: evaluate creatinine clearance before initiation and during therapy.
  • Use caution in elderly: increased susceptibility to volume depletion and orthostatic hypotension.
  • Avoid concurrent lithium therapy: risk of lithium toxicity may be heightened.
  • Adjust dose in hepatic impairment: reduced clearance may require dose modification.
  • Store at below 25°C: keep in the original pack, protect from moisture.

Avoid Interactions

Indapamide can interact with other medicines, affecting its efficacy or safety.

Major Interactions (Avoid)

  • Lithium: increased risk of lithium toxicity.
  • Digoxin: enhanced digoxin levels may lead to toxicity.
  • Cyclosporine: may amplify nephrotoxic effects.

Moderate Interactions (Monitor Closely)

  • ACE inhibitors or ARBs: additive blood‑pressure lowering effect.
  • NSAIDs: may reduce diuretic efficacy and impair renal function.
  • Beta‑blockers: potential for excessive hypotension.
  • Antidiabetic sulfonylureas: may enhance hypoglycemic effect.

Frequently Asked Questions

Indapamide Biogaran is a prescription‑only thiazide‑like diuretic indicated for the treatment of hypertension and for reducing edema associated with heart‑failure. It helps lower blood pressure and promotes the excretion of excess fluid, thereby improving symptoms in adult patients under medical supervision.

Indapamide inhibits the sodium‑chloride symporter in the distal convoluted tubule of the kidney, decreasing Na⁺/Cl⁻ reabsorption. This leads to increased urinary excretion of sodium and water, which reduces plasma volume and peripheral vascular resistance, resulting in lowered blood pressure and decreased fluid accumulation.

The appropriate dose of Indapamide Biogaran is determined by the prescribing clinician based on the individual’s medical condition, response to therapy, and renal function. Dosage adjustments are made according to clinical guidelines and patient monitoring; patients should follow the prescriber’s instructions and not alter the dose on their own.

Safety data for Indapamide during pregnancy and lactation are limited, and the drug is generally avoided unless the potential benefit outweighs the risk. Healthcare providers should evaluate the risk‑benefit profile for each patient, and alternative therapies may be considered for pregnant or nursing women.

To request Indapamide Biogaran, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Compared with conventional thiazide diuretics, Indapamide offers a longer duration of action and a lower incidence of metabolic disturbances such as hypokalemia. It is often used when additional diuretic potency is needed or when patients experience side effects with other agents, but the choice of therapy depends on individual patient factors and clinician judgment.

Indapamide Biogaran tablets should be stored at temperatures below 25 °C, in their original packaging, protected from moisture and direct sunlight. Keeping the product in a dry, controlled environment helps maintain its stability and potency throughout its shelf life.

Indapamide Biogaran is taken orally, usually once daily in the morning with or without food, as directed by the prescriber. Swallow the tablet whole with a glass of water; do not crush or chew unless specifically instructed. Consistent timing helps maintain stable blood pressure control.

The most serious risks include severe electrolyte disturbances such as hyponatremia or hypokalemia, dehydration, acute kidney injury, and rare allergic reactions like Stevens‑Johnson syndrome. Patients should be monitored regularly for signs of these conditions, and any concerning symptoms should prompt immediate medical evaluation.

Indapamide Biogaran is contraindicated in patients with known hypersensitivity to indapamide or other sulfonamide‑derived drugs, and should be used with caution in individuals with severe renal or hepatic impairment, uncontrolled diabetes, or those taking interacting medications such as lithium. Clinicians must assess each patient’s medical history before initiating therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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