Product image of Indapamide Lp Krka (Indapamide) supplied by GNH India

Indapamide Lp Krka

Active Ingredient:
Indapamide
Origin:
EU

Indapamide Lp Krka (Indapamide)

Indapamide, the active ingredient in Indapamide Lp Krka, is a thiazide‑like diuretic presented as a tablet for oral use. It lowers blood pressure and reduces fluid retention in patients with hypertension, heart‑failure‑related edema, or renal‑disease‑associated edema.

GNH India supplies Indapamide Lp Krka as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides regulatory‑approved batches to meet global demand. Logistics are managed with temperature‑controlled shipping where required, ensuring product integrity upon delivery.

Manufacturer / TM Owner

Krka, D.D., Novo Mesto

1
Pack/s
This product is added to your enquiry list

Request a Quote

Please fill out the form below and our team will get back to you shortly with pricing and further information.

A minimum order value applies. Our team will confirm the exact amount or quantity after reviewing your requirements.

Indications & Clinical Uses

  • Indapamide is used to manage conditions related to elevated blood pressure and fluid overload.
  • Hypertension: reduces systolic and diastolic blood pressure, improving cardiovascular risk profile.
  • Edema associated with heart failure: promotes diuresis to decrease fluid accumulation and relieve symptoms.
  • Edema associated with renal disease: enhances urinary sodium excretion to control swelling in chronic kidney disease.

How It Works

  • Indapamide acts on the distal convoluted tubule of the nephron by inhibiting the Na⁺/Cl⁻ cotransporter. This blockade reduces sodium and chloride reabsorption, leading to increased urinary excretion of water and electrolytes. The resulting diuresis lowers plasma volume and peripheral vascular resistance, contributing to blood‑pressure reduction and edema control.

Side Effects

Indapamide may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Dizziness
  • Headache
  • Increased urination
  • Electrolyte imbalance (low potassium)

Serious or Rare Side Effects

  • Severe dehydration
  • Acute kidney injury
  • Severe hypotension

Precautions & Warnings

  • Before initiating therapy, clinicians should consider several safety measures.
  • Monitor electrolytes: regular blood tests to detect sodium and potassium changes.
  • Assess renal function: evaluate kidney performance before and during treatment.
  • Adjust dose in elderly: start low and monitor for orthostatic hypotension.
  • Avoid use in severe hepatic impairment: contraindicated due to altered metabolism.
  • Store at ambient temperature: keep in original container, protect from moisture and direct sunlight.

Avoid Interactions

Indapamide can interact with several medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Lithium: increased lithium levels leading to toxicity.
  • NSAIDs: reduced diuretic efficacy and possible renal impairment.
  • ACE inhibitors/ARBs: risk of excessive potassium rise.
  • Antidiabetic drugs: enhanced hypoglycemic effect.

Moderate Interactions (Monitor Closely)

  • Digoxin: altered serum levels.
  • Beta‑blockers: additive blood‑pressure lowering.
  • SSRIs: increased risk of hyponatremia.

Frequently Asked Questions

Indapamide Lp Krka is prescribed to lower high blood pressure and to reduce fluid buildup in patients with edema caused by heart failure or chronic kidney disease. By promoting the excretion of excess salt and water, it helps control hypertension and alleviates swelling.

Indapamide blocks the sodium‑chloride transporter in the distal convoluted tubule of the kidney. This inhibition reduces reabsorption of sodium and chloride, leading to increased urine output. The loss of fluid lowers blood volume and peripheral vascular resistance, which together lower blood pressure and diminish edema.

The exact dose of Indapamide Lp Krka is determined by the prescribing clinician based on the patient’s medical condition, response to therapy, and renal function. Healthcare professionals adjust the regimen to achieve optimal blood‑pressure control or edema reduction while monitoring safety.

Safety data for indapamide in pregnancy and lactation are limited. It should only be used if the potential benefit justifies the possible risk to the fetus or infant. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss alternatives with their healthcare provider.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any temperature‑controlled requirements) and necessary import documentation.

Indapamide belongs to the thiazide‑like diuretic class and offers a longer duration of action with a lower risk of metabolic disturbances compared with classic thiazides. It is often preferred when clinicians need effective blood‑pressure control combined with modest diuretic effect, whereas loop diuretics are chosen for more severe fluid overload.

Indapamide Lp Krka tablets should be stored at ambient temperature, below 25 °C, in the original packaging. Protect the product from moisture, direct sunlight, and extreme temperatures to maintain potency throughout its shelf life.

The medication is taken orally, usually with a glass of water. It can be taken with or without food, but patients should follow the prescribing physician’s instructions regarding timing and whether it should be taken in the morning to reduce nocturnal diuresis.

Serious risks include severe dehydration, acute kidney injury, marked electrolyte disturbances such as hyponatremia or hypokalemia, and profound hypotension. Patients should be educated to report symptoms like dizziness, fainting, rapid weight loss, or muscle weakness promptly.

Indapamide is contraindicated in patients with known hypersensitivity to indapamide or other sulfonamide diuretics, severe renal or hepatic impairment, and in those with anuria. Caution is also advised for individuals with uncontrolled diabetes, gout, or electrolyte disorders.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

Disclaimer

At GNH India, we aim to provide information that is expert-reviewed, accurate, and reliable. However, all content on this platform is intended for general informational purposes only and does not constitute professional medical advice, diagnosis, or treatment. While efforts are made to maintain accuracy and currency, the information may contain errors, omissions, or may not reflect the latest developments. Always consult a qualified healthcare professional regarding any medical concerns.

All product names, brand names, trademarks and registered trademarks displayed on this website are the property of their respective owners. This website and its operator are not affiliated with, endorsed by, or authorized by any such trade mark owners unless expressly stated. Any reference to product names or trademarks is made solely for descriptive and informational purposes. No commercial relationship, sponsorship, approval, or association with any trademark owner should be inferred. Information provided herein does not constitute promotion, advertising, or an offer for sale of any medicinal product and is intended solely for general informational purposes.

All trademarks and brand names displayed on this website are used strictly in accordance with the provisions of the Trade Marks Act, 1999, specifically Sections 30 and 30(1) governing fair use. Trademark ownership has been accurately attributed under the "Manufacturer/ TM Owner" section in compliance with statutory requirements.

Ordering Process

Simple, Secure, and Seamless

Learn how our streamlined ordering process guarantees fast, compliant, and reliable access to essential medicines worldwide.

Quote request form

01

Submit Quote Request Form

Tell us what medications you need by filling out our simple form and uploading a valid document.

Price estimate review

02

We Review & Send Estimate

Our licensed pharmacists will verify your details and provide you with a detailed cost estimate.

Secure payment

03

Confirm & Make Payment

Discuss any queries, approve the estimate, and complete your payment.

Worldwide delivery

04

Get Delivered

Your medicines, safely packed and delivered to your door or nearest airport — hassle-free.

Quality You Can Trust

Our internationally recognized certifications underscore our commitment to safety, quality, and excellence.