Product image of Indapamide Lp Zydus (Indapamide) supplied by GNH India

Indapamide Lp Zydus

Active Ingredient:
Indapamide
Origin:
EU

Indapamide Lp Zydus (Indapamide)

Indapamide, the active ingredient in Indapamide Lp Zydus, is a thiazide‑like diuretic presented as a tablet for oral use. It treats hypertension and helps reduce edema associated with heart failure or renal disease.

GNH India supplies Indapamide Lp Zydus as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Zydus France

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Indications & Clinical Uses

Indapamide is used in the management of conditions related to fluid overload and elevated blood pressure.

  • Hypertension: lowers systolic and diastolic blood pressure, reducing cardiovascular risk.
  • Edema associated with heart failure: promotes diuresis to decrease fluid accumulation.
  • Edema associated with renal disease: enhances urinary excretion to alleviate swelling.

How It Works

  • Indapamide inhibits sodium and chloride reabsorption in the distal convoluted tubule of the nephron, leading to increased urinary excretion of water and electrolytes. The resulting reduction in plasma volume, together with direct vasodilatory effects on arteriolar smooth muscle, contributes to a sustained decrease in systemic blood pressure.

Side Effects

Indapamide may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Dizziness: sensation of light‑headedness, especially after standing.
  • Headache: mild to moderate intensity.
  • Increased urination: more frequent need to void.
  • Electrolyte imbalance (low potassium): may cause muscle weakness.
  • Fatigue: feeling of tiredness or reduced energy.
  • Muscle cramps: involuntary tightening of muscles.

Serious or Rare Side Effects

  • Severe dehydration: marked fluid loss requiring medical attention.
  • Hyponatremia: dangerously low sodium levels.
  • Hyperuricemia or gout attacks: elevated uric acid leading to joint pain.
  • Allergic reactions: rash, itching, or swelling.
  • Significant blood pressure drop: hypotension with risk of fainting.
  • Pancreatitis: inflammation of the pancreas, a medical emergency.

Precautions & Warnings

Before initiating therapy, clinicians should evaluate patient‑specific factors and monitor for potential complications.

  • Monitor electrolytes: check serum potassium and sodium regularly.
  • Assess renal function: evaluate creatinine clearance before and during treatment.
  • Use caution in the elderly: increased susceptibility to orthostatic hypotension.
  • Avoid abrupt discontinuation: tapering may be needed to prevent rebound hypertension.
  • Concomitant NSAIDs: may reduce diuretic efficacy and increase renal risk.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Indapamide may interact with several drug classes, requiring attention to dosage and monitoring.

Major Interactions (Avoid)

  • Lithium: risk of lithium toxicity due to reduced clearance.
  • ACE inhibitors or ARBs: may cause excessive potassium elevation.
  • NSAIDs: can diminish diuretic effect and impair renal function.

Moderate Interactions (Monitor Closely)

  • Antidiabetic agents: increased risk of hypoglycemia.
  • Corticosteroids: additive potassium loss.
  • Other antihypertensives: additive blood pressure‑lowering effect.
  • Antidepressants (SSRIs): potential for hyponatremia.

Frequently Asked Questions

Indapamide Lp Zydus is prescribed to lower high blood pressure and to reduce fluid retention (edema) that occurs with heart failure or chronic kidney disease. By promoting the excretion of excess water and salts, it helps control hypertension and alleviates swelling in the legs, ankles, or lungs.

Indapamide blocks the sodium‑chloride transporter in the distal convoluted tubule of the kidney, decreasing reabsorption of these ions. This leads to increased urine output and a reduction in blood volume. Additionally, it relaxes arteriolar smooth muscle, producing a vasodilatory effect that further lowers systemic blood pressure.

The specific dose of Indapamide Lp Zydus is determined by the prescribing healthcare professional based on the patient’s condition, response, and renal function. Dosage may be adjusted over time, and patients should follow the exact regimen provided by their physician.

Safety data for Indapamide in pregnancy and lactation are limited, and the medication is generally classified as contraindicated or to be used only if the potential benefit outweighs the risk. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss alternatives with their doctor.

To place an order, submit an enquiry on the product page at gnhindia.com indicating the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details (including any cold‑chain requirements), and necessary import documentation.

Indapamide belongs to the thiazide‑like class and offers a longer duration of action with a lower incidence of metabolic disturbances compared with classic thiazides like hydrochlorothiazide. It also provides modest vasodilatory properties, which can be advantageous in patients who need both diuretic and antihypertensive effects.

Store the tablets at room temperature, below 25 °C, in the original packaging. Keep them away from moisture, heat, and direct sunlight to maintain potency. Do not store in the bathroom or near a kitchen sink where humidity is high.

Indapamide Lp Zydus is taken orally, usually once daily in the morning with or without food, as directed by the prescriber. Swallow the tablet whole with a full glass of water; do not crush or chew unless specifically instructed.

Serious adverse events include severe dehydration, electrolyte disturbances such as hyponatremia or hypokalemia, marked drops in blood pressure leading to fainting, and rare allergic reactions that may cause swelling of the face or throat. Patients should seek immediate medical attention if they experience these symptoms.

Indapamide is contraindicated in patients with anuria (no urine output), severe renal impairment, or known hypersensitivity to the drug. Caution is also advised for individuals with gout, severe liver disease, or those taking lithium, as the medication can exacerbate these conditions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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