Product image of Indapamide Sr Pliva (Indapamide) supplied by GNH India

Indapamide Sr Pliva

Active Ingredient:
Indapamide
Origin:
EU

Indapamide Sr Pliva (Indapamide)

Indapamide, the active ingredient in Indapamide Sr Pliva, is a thiazide-like diuretic presented as a tablet for oral use. It is used to treat hypertension and edema associated with congestive heart failure in adult patients.

GNH India supplies Indapamide Sr Pliva as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Pliva Hrvatska D.O.O.

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Indications & Clinical Uses

  • Indapamide is a thiazide‑like diuretic used to manage conditions related to fluid overload and high blood pressure.
  • Hypertension: lowers systolic and diastolic blood pressure, reducing cardiovascular risk.
  • Edema associated with congestive heart failure: promotes diuresis to reduce fluid accumulation.
  • Adjunct in resistant hypertension: assists in blood pressure reduction when combined with other antihypertensive agents.

How It Works

  • Indapamide blocks the Na⁺/Cl⁻ cotransporter in the distal convoluted tubule of the kidney, decreasing sodium and chloride reabsorption. This leads to increased urinary excretion of water and electrolytes, reducing extracellular fluid volume and consequently lowering arterial pressure while alleviating edema.

Side Effects

Indapamide may cause a range of adverse reactions, from mild to serious.

Common Side Effects

  • Dizziness or light‑headedness
  • Headache
  • Increased frequency of urination
  • Electrolyte imbalance, especially low potassium
  • Mild nausea or abdominal discomfort
  • Fatigue or weakness

Serious or Rare Side Effects

  • Severe dehydration
  • Significant electrolyte disturbances (hypokalemia, hyponatremia)
  • Allergic reactions such as rash, angioedema, or anaphylaxis
  • Acute renal impairment
  • Gout attacks due to uric acid elevation

Precautions & Warnings

  • Before starting indapamide, several safety considerations should be observed.
  • Monitor electrolytes: regular blood tests for potassium, sodium, and magnesium levels.
  • Assess renal function: evaluate kidney function prior to therapy.
  • Avoid abrupt discontinuation: taper under medical supervision to prevent rebound hypertension.
  • Use caution in diabetes: monitor blood glucose as diuretics may affect control.
  • Pregnancy and lactation: discuss potential risks with a healthcare provider.
  • Store at room temperature: keep below 25°C in the original pack, protect from moisture.

Avoid Interactions

Indapamide can interact with several medicines, requiring attention to avoid adverse outcomes.

Major Interactions (Avoid)

  • Lithium: increased lithium levels may cause toxicity.
  • NSAIDs: may diminish diuretic effect and impair renal function.
  • ACE inhibitors or ARBs: combined use can lead to severe hypotension and electrolyte imbalance.

Moderate Interactions (Monitor Closely)

  • Antidiabetic agents: may enhance hypoglycemic effect.
  • Other diuretics: additive diuretic action can cause dehydration.
  • Corticosteroids: may increase risk of hypokalemia.

Frequently Asked Questions

Indapamide Sr Pliva contains the diuretic indapamide and is prescribed to lower high blood pressure and to reduce fluid buildup in patients with edema linked to congestive heart failure. By promoting the excretion of sodium and water, it helps control cardiovascular strain and improves symptom management in these conditions.

Indapamide acts on the distal convoluted tubule of the kidney, where it blocks the Na⁺/Cl⁻ cotransporter. This inhibition reduces sodium and chloride reabsorption, leading to increased urine output (diuresis). The resulting loss of extracellular fluid lowers blood volume, which in turn decreases arterial pressure and alleviates edema.

The specific dose of Indapamide Sr Pliva is determined by the prescribing healthcare professional based on the individual’s medical condition, response to therapy, and other factors such as kidney function. Patients should follow the prescriber’s instructions and not adjust the dose without medical guidance.

Safety data for indapamide in pregnancy and lactation are limited, and the medication should only be used if the potential benefits outweigh the risks. Healthcare providers will evaluate the mother’s condition and consider alternative treatments when possible. Breastfeeding mothers should discuss potential exposure with their doctor.

To place an order, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, confirming trade or institutional credentials before providing pricing, availability, shipping details, and any necessary import documentation.

Indapamide belongs to the thiazide‑like diuretic class and offers a longer duration of action with a lower incidence of metabolic side effects compared with traditional thiazides such as hydrochlorothiazide. It is often chosen for patients who need effective blood‑pressure control and edema reduction while minimizing electrolyte disturbances.

Store the product at room temperature, preferably below 25 °C. Keep the tablets in their original container, protect them from moisture and direct sunlight, and ensure they are out of reach of children. Do not refrigerate or freeze the medication.

Indapamide Sr Pliva is taken orally, usually with a glass of water. It may be taken with or without food, as directed by the prescriber. Patients should swallow the tablet whole and avoid crushing or chewing it unless instructed otherwise.

The most serious risks include severe dehydration, significant electrolyte imbalances such as low potassium or sodium, acute kidney injury, and rare allergic reactions like rash or angioedema. Prompt medical attention is required if symptoms such as faintness, muscle weakness, rapid weight loss, or swelling occur.

Indapamide is contraindicated in individuals with known hypersensitivity to indapamide or other sulfonamide‑derived drugs. Patients with severe renal impairment, uncontrolled electrolyte disturbances, or those taking interacting medications such as lithium without close monitoring should avoid its use unless supervised by a healthcare professional.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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