Product image of Indapen Sr (Indapamide) supplied by GNH India

Indapen Sr

Active Ingredient:
Indapamide
Origin:
EU

Indapen Sr (Indapamide)

Indapamide, the active ingredient in Indapen Sr, is a thiazide‑like diuretic presented as an oral tablet for oral use. It helps lower blood pressure and reduces fluid retention in adults with hypertension or edema related to heart failure or renal disease.

GNH India supplies Indapen Sr as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide. The company adheres to stringent quality standards and provides reliable logistics for global distribution. Clients benefit from comprehensive regulatory support and consistent product availability across markets.

Manufacturer / TM Owner

Zaklady Farmaceutyczne Polpharma S.A.

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Indications & Clinical Uses

Indapamide is used to manage conditions within the cardiovascular and renal disease spectrum.

  • Hypertension: lowers elevated blood pressure, reducing risk of cardiovascular complications.
  • Edema associated with heart failure: promotes fluid loss to relieve pulmonary and peripheral congestion.
  • Edema associated with renal disease: enhances urinary excretion to decrease fluid overload.

How It Works

  • Indapamide acts on the distal convoluted tubule of the nephron by inhibiting the Na⁺/Cl⁻ cotransporter. This blockade reduces sodium and chloride reabsorption, leading to increased excretion of water and electrolytes. The resulting diuresis decreases plasma volume, which lowers peripheral vascular resistance and blood pressure. Additionally, modest vasodilatory effects contribute to its antihypertensive action.

Side Effects

Indapamide may cause a range of adverse reactions, varying from mild to serious.

Common Side Effects

  • Dizziness or light‑headedness.
  • Headache.
  • Increased urinary frequency.
  • Nausea or abdominal discomfort.
  • Fatigue.
  • Mild electrolyte disturbances (e.g., low potassium).

Serious or Rare Side Effects

  • Severe dehydration or electrolyte imbalance.
  • Hyponatremia or hyperuricemia leading to gout.
  • Allergic reactions such as rash or angioedema.
  • Blood dyscrasias (e.g., leukopenia, thrombocytopenia).
  • Acute pancreatitis.

Precautions & Warnings

When prescribing Indapamide, clinicians should consider several safety measures.

  • Electrolyte monitoring: regularly check serum potassium and sodium levels.
  • Renal function assessment: evaluate creatinine clearance before initiation and during therapy.
  • Hepatic impairment: use with caution in patients with liver disease.
  • Elderly patients: start at lower doses and monitor for orthostatic hypotension.
  • Concomitant antihypertensives: adjust doses to avoid excessive blood pressure drop.
  • Store at room temperature: keep in the original container, protect from moisture and direct sunlight.

Avoid Interactions

Indapamide can interact with other medicines, requiring attention to the interaction level.

Major Interactions (Avoid)

  • Lithium: increased lithium concentrations may cause toxicity.
  • Antidiabetic agents (insulin, sulfonylureas): risk of hypoglycemia due to enhanced glucose clearance.
  • Cyclosporine: may reduce diuretic efficacy and increase nephrotoxicity.

Moderate Interactions (Monitor Closely)

  • NSAIDs (e.g., ibuprofen): may blunt diuretic effect and impair renal function.
  • ACE inhibitors or ARBs: combined use can lead to excessive potassium rise.
  • Digoxin: risk of elevated digoxin levels due to electrolyte shifts.

Frequently Asked Questions

Indapen Sr contains indapamide, which is prescribed to lower high blood pressure and to reduce fluid buildup in patients with edema caused by heart failure or chronic kidney disease. It helps control hypertension and manage swelling in the legs, lungs, or abdomen associated with these conditions.

Indapamide blocks the sodium‑chloride transporter in the distal convoluted tubule of the kidney. By preventing reabsorption of these ions, it promotes the excretion of water and salts, decreasing blood volume and peripheral resistance, which together lower blood pressure and reduce fluid retention.

The exact dose of Indapen Sr is determined by the prescribing clinician based on the patient’s medical condition, age, kidney function and response to therapy. Dosage adjustments are made individually; patients should follow the prescriber’s instructions and not alter the dose on their own.

Indapamide is classified as Pregnancy Category B, indicating that animal studies have not shown risk to the fetus and there are no adequate human studies. It may be used during pregnancy only if clearly needed. Limited data are available for breastfeeding, so a healthcare professional should evaluate the risk‑benefit balance.

To request Indapen Sr, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any necessary import documentation.

Indapamide belongs to the thiazide‑like class, offering a longer duration of action and a milder impact on potassium compared with classic thiazides such as hydrochlorothiazide. It also provides modest vasodilatory effects, which can result in better blood‑pressure control for some patients while maintaining a comparable safety profile.

Indapen Sr should be stored at room temperature, below 25 °C. Keep the tablets in the original packaging, protect them from moisture and direct sunlight, and ensure the container is tightly closed to maintain product stability.

Indapen Sr is taken orally, usually with a full glass of water. It can be taken with or without food, but patients should follow the prescribing doctor’s guidance on timing and whether to take it in the morning or evening to minimize nighttime urination.

Serious risks include severe dehydration, electrolyte disturbances such as low potassium or sodium, and rare allergic reactions like angioedema. Patients should be alert for symptoms such as dizziness, rapid weight loss, muscle cramps, or rash and seek medical attention promptly if they occur.

Indapen Sr is contraindicated in patients with anuria, severe renal impairment, or known hypersensitivity to indapamide or other sulfonamide‑derived drugs. Caution is also advised for individuals with uncontrolled diabetes, gout, or those taking lithium, as the drug may exacerbate these conditions.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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